{"687062":{"#nid":"687062","#data":{"type":"event","title":"MS Defense by Yixun Tan","body":[{"value":"\u003Cp\u003EIn partial fulfillment of the requirements for the degree of\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EMaster of Science in Biology\u003C\/p\u003E\u003Cp\u003Ein the\u003C\/p\u003E\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EYixun Tan\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EWill defend his thesis\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u201cRole of RNase H1 in RNA-mediated End Joining Repair\u201d\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E12 JANUARY 2026\u003C\/p\u003E\u003Cp\u003E14:30\u003C\/p\u003E\u003Cp\u003E\u003Ca href=\u0022https:\/\/gatech.zoom.us\/j\/91594268291?pwd=Lv4EbpeocuTRDSbmb6ZIjWXssDS0Sz.1\u0022\u003Ehttps:\/\/gatech.zoom.us\/j\/91594268291?pwd=Lv4EbpeocuTRDSbmb6ZIjWXssDS0Sz.1\u003C\/a\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EThesis Advisor:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EDr. Francesca Storici\u003C\/p\u003E\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee Members:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EDr. Yury O. Chernoff\u003C\/p\u003E\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003EDr. Andrew McShan\u003C\/p\u003E\u003Cp\u003ESchool of Chemistry \u0026amp; Biochemistry\u003C\/p\u003E\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EAbstract: \u003C\/strong\u003ERNA has increasingly been recognized as an active participant in the repair of DNA double-strand breaks (DSBs), extending the classical DNA-centric view,In multiple organisms, transcript RNA and RNA\u2013DNA hybrids have been shown to influence repair efficiency and pathway choice, yet the regulatory mechanisms governing RNA-mediated end joining at chromosomal breaks remain incompletely understood. RNase H1, a conserved enzyme that selectively degrades the RNA strand of RNA\u2013DNA hybrids, represents a key factor linking RNA metabolism to genome maintenance.\u003C\/p\u003E\u003Cp\u003EThis thesis investigates the role of RNase H1 in RNA-mediated end-joining repair using a chromosomal reporter system in Saccharomyces cerevisiae. Antisense and branch\u0394 intron-containing constructs were integrated into the yeast genome to generate spliced and non-spliced RNA species in a defined chromosomal context. These constructs were analyzed in parallel wild-type and rnh1\u0394 backgrounds, allowing direct assessment of how RNase H1 status influences RNA processing and repair outcomes. A genetically controlled strain panel was generated through targeted deletion and restoration of the endogenous RNH1 locus using the delitto perfetto strategy.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":"","format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u201cRole of RNase H1 in RNA-mediated End Joining Repair\u201d\u003C\/strong\u003E\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u201cRole of RNase H1 in RNA-mediated End Joining Repair\u201d"}],"uid":"27707","created_gmt":"2026-01-05 17:03:43","changed_gmt":"2026-01-05 17:03:43","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2026-01-12T14:30:25-05:00","event_time_end":"2026-01-12T16:30:25-05:00","event_time_end_last":"2026-01-12T16:30:25-05:00","gmt_time_start":"2026-01-12 19:30:25","gmt_time_end":"2026-01-12 21:30:25","gmt_time_end_last":"2026-01-12 21:30:25","rrule":null,"timezone":"America\/New_York"},"location":"ZOOM","extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"111531","name":"ms defense"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78771","name":"Public"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}