{"687044":{"#nid":"687044","#data":{"type":"event","title":"Divisional Seminar - Prof. Kyeng Min Park (Daegu Catholic University School of Medicine)","body":[{"value":"\u003Cdiv\u003E\u003Cstrong\u003ETitle:\u003C\/strong\u003E\u0026nbsp;Ultrastable and tunable host-guest chemistry for bioimaging and spatiotemporal proteomics\u003C\/div\u003E\u003Cdiv\u003E\u0026nbsp;\u003C\/div\u003E\u003Cdiv\u003E\u003Cstrong\u003EAbstract:\u003C\/strong\u003E\u003C\/div\u003E\u003Cdiv\u003EHigh-affinity molecular recognition is a fundamental supramolecular principle underpinning\u003C\/div\u003E\u003Cdiv\u003Ebioimaging and proteomics. The streptavidin-biotin (Sv-Bt) interaction has long served as the benchmark for\u003C\/div\u003E\u003Cdiv\u003Estrong noncovalent binding; however, its practical application is often constrained by the large molecular size of\u003C\/div\u003E\u003Cdiv\u003ESv, interference from endogenous Bt, and limited control over binding dynamics. In this talk, I introduce a\u003C\/div\u003E\u003Cdiv\u003Esynthetic supramolecular platform based on ucurbit[7]uril (CB[7], a pumpkin-shaped macrocyclic host molecule)\u003C\/div\u003E\u003Cdiv\u003Eand its ultrahigh-affinity small-molecule guests, including adamantyl ammonium (AdA) and ferrocenyl ammonium\u003C\/div\u003E\u003Cdiv\u003E(FcA). The CB[7]\u2013guest interaction exhibits exceptionally high binding constants (K\u2090 \u2248 10\u00b9\u00b2\u201310\u00b9\u2075 M\u207b\u00b9), rivaling the\u003C\/div\u003E\u003Cdiv\u003Enatural Sv-Bt system. Importantly, this platform combines extraordinary binding strength with bio-orthogonality\u003C\/div\u003E\u003Cdiv\u003Eand chemical tunability. Crucially, unlike the nearly irreversible nature of Sv-Bt, the CB[7]\u2013guest interaction offers\u003C\/div\u003E\u003Cdiv\u003Etunable controllability. Binding affinity and reversibility can be rationally modulated through guest design,\u003C\/div\u003E\u003Cdiv\u003Ecompetitive displacement, and environmental cues, enabling on-demand control over molecular capture and\u003C\/div\u003E\u003Cdiv\u003Erelease. I will demonstrate how these unique features enable real-time bioimaging of autophagosome\u2013lysosome\u003C\/div\u003E\u003Cdiv\u003Efusion, as well as spatiotemporal proteomics, including mitochondrial and nuclear proteome mapping and\u003C\/div\u003E\u003Cdiv\u003Eputative biomarker discovery.\u003C\/div\u003E\u003Cdiv\u003E\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003C\/div\u003E\u003Cdiv\u003E\u003Cstrong\u003EBio:\u003C\/strong\u003E\u003C\/div\u003E\u003Cdiv\u003EDr. Park received his Ph.D. in Supramolecular Chemistry from POSTECH, South Korea, in 2009. He\u003C\/div\u003E\u003Cdiv\u003Esubsequently completed a two-year postdoctoral fellowship at Harvard University. He then returned to South\u003C\/div\u003E\u003Cdiv\u003EKorea to serve as a Senior Researcher at the Semiconductor R\u0026amp;D Center of Samsung Electronics. In 2014, he\u003C\/div\u003E\u003Cdiv\u003Ejoined the Institute for Basic Science (IBS), South Korea, where he led a research group until 2021. He is currently\u003C\/div\u003E\u003Cdiv\u003Ean assistant Professor in the Department of Biochemistry at Daegu Catholic University School of Medicine in\u003C\/div\u003E\u003Cdiv\u003ESouth Korea. His research focuses on the development of supramolecular tools and self-assembled materials\u003C\/div\u003E\u003Cdiv\u003Efor applications in chemical biology, biomedicine and environmental science. Dr. Park is currently on sabbatical\u003C\/div\u003E\u003Cdiv\u003Ein the Finn laboratory through summer, 2026.\u003C\/div\u003E","summary":"","format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EOne in the series of the SoCB seminars.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"School of Chemistry \u0026 Biochemistry - Seminar Series"}],"uid":"35342","created_gmt":"2026-01-02 16:51:13","changed_gmt":"2026-01-02 16:53:42","author":"mcurtis41","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2026-01-20T11:00:00-05:00","event_time_end":"2026-01-20T12:00:00-05:00","event_time_end_last":"2026-01-20T12:00:00-05:00","gmt_time_start":"2026-01-20 16:00:00","gmt_time_end":"2026-01-20 17:00:00","gmt_time_end_last":"2026-01-20 17:00:00","rrule":null,"timezone":"America\/New_York"},"location":"MoSE 3201A","extras":[],"hg_media":{"678908":{"id":"678908","type":"image","title":"Kyeng-Min-Park.jpg","body":null,"created":"1767372803","gmt_created":"2026-01-02 16:53:23","changed":"1767372803","gmt_changed":"2026-01-02 16:53:23","alt":"Kyeng Min Park","file":{"fid":"263004","name":"Kyeng-Min-Park.jpg","image_path":"\/sites\/default\/files\/2026\/01\/02\/Kyeng-Min-Park.jpg","image_full_path":"http:\/\/hg.gatech.edu\/\/sites\/default\/files\/2026\/01\/02\/Kyeng-Min-Park.jpg","mime":"image\/jpeg","size":171259,"path_740":"http:\/\/hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/2026\/01\/02\/Kyeng-Min-Park.jpg?itok=36fKvnq4"}}},"media_ids":["678908"],"groups":[{"id":"85951","name":"School of Chemistry and Biochemistry"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"177814","name":"Postdoc"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Cstrong\u003EHost:\u003C\/strong\u003E\u0026nbsp;M.G. Finn\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}