{"686105":{"#nid":"686105","#data":{"type":"event","title":"IBB Seminar","body":[{"value":"\u003Cp\u003E\u003Cbr\u003E\u003Ca href=\u0022https:\/\/www.cincinnatichildrens.org\/research\/divisions\/g\/thoracic-surgery\/labs\/helmrath\u0022\u003EMichael A. Helmrath, MD\u003C\/a\u003E\u003Cbr\u003E\u003Cstrong\u003ESurgical Director, Intestinal Rehabilitation Program\u003C\/strong\u003E\u003Cbr\u003E\u003Cstrong\u003ECincinnati Children\u0027s Hospital Medical Center\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cem\u003EHYBRID EVENT\u003C\/em\u003E\u003Cbr\u003E*Register \u003Ca href=\u0022https:\/\/gatech.zoom.us\/webinar\/register\/WN_f09zB10fQsSOe5CqpN_z8w\u0022\u003Ehere\u003C\/a\u003E for Zoom link for virtual participation\u003C\/p\u003E\u003Cp\u003EOver the past 15 years, our laboratory as established and expanded on methodology to differentiate iPSC to GI tissues that include esophagus, stomach, small bowel and colon. Key advances establishing in vivo modeling in murine and rat host has introduced a functional ENS and established methods to provide a humanized immune response. The methods to isolate mesenchyme and endoderm provide a model to study key factors supporting engraftment and provides a potential product for both clinical and research studies. Recent methods to establish a robust tissue for engraftment utilizing a methods we term Confined Culture System provides both the ability to engraft all regionalized tissues and provide a functional ENS without the need to co culture neurospheres. Clinical translation of these models requires a GMP protocol and methods with a strategy to use both Allogenic and Autologous lines. We will present our ongoing efforts to achieve this.\u003C\/p\u003E","summary":"","format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E\u0022iPSC Generated Human Intestine: Clinical and Research Approaches to Modeling Human Development and Disease\u0022 - Michael A. Helmrath, MD, Cincinnati Children\u0027s Hospital Medical Center\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022iPSC Generated Human Intestine: Clinical and Research Approaches to Modeling Human Development and Disease\u0022 - Michael A. Helmrath, MD, Cincinnati Children\u0027s Hospital Medical Center"}],"uid":"27195","created_gmt":"2025-10-31 15:18:19","changed_gmt":"2025-10-31 15:23:01","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2025-12-09T11:00:00-05:00","event_time_end":"2025-12-09T12:00:00-05:00","event_time_end_last":"2025-12-09T12:00:00-05:00","gmt_time_start":"2025-12-09 16:00:00","gmt_time_end":"2025-12-09 17:00:00","gmt_time_end_last":"2025-12-09 17:00:00","rrule":null,"timezone":"America\/New_York"},"location":"Petit Biotechnology Building, 315 Ferst Drive, NW, Suddath Seminar Room 1128, Atlanta, GA 30332","extras":[],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"},{"id":"1254","name":"Wallace H. Coulter Dept. of Biomedical Engineering"}],"categories":[],"keywords":[{"id":"187423","name":"go-bio"},{"id":"189814","name":"go-researchevents"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"177814","name":"Postdoc"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:connect@ibb.gatech.edu\u0022\u003Econnect@ibb.gatech.edu\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}