{"685218":{"#nid":"685218","#data":{"type":"news","title":"Breathtaking Breakthrough: Lung-on-a-Chip Defends Itself ","body":[{"value":"\u003Cp\u003EOn a clear polymer chip, soft and pliable like a gummy bear, a microscopic lung comes alive \u2014 expanding, circulating, and, for the first time, protecting itself like a living organ.\u0026nbsp;\u003Cbr\u003E\u003Cbr\u003EFor \u003Ca href=\u0022https:\/\/research.gatech.edu\/people\/ankur-singh\u0022\u003EAnkur Singh,\u003C\/a\u003E director of Georgia Tech\u2019s \u003Ca href=\u0022https:\/\/immunoengineering.gatech.edu\/\u0022\u003ECenter for Immunoengineering\u003C\/a\u003E, watching immune cells rush through the chip took his breath away. Singh co-directed the study with longtime collaborator \u003Ca href=\u0022https:\/\/engineering.vanderbilt.edu\/bio\/?pid=krishnendu-roy\u0022\u003EKrishnendu \u201cKrish\u201d Roy\u003C\/a\u003E, former Regents Professor and director of the \u003Ca href=\u0022https:\/\/cellmanufacturingusa.org\/\u0022\u003ENSF Center for Cell Manufacturing Technologies\u003C\/a\u003E at Tech and now the Bruce and Bridgitt Evans dean of engineering and University Distinguished Professor at Vanderbilt University. \u003Ca href=\u0022https:\/\/bioengineering.gatech.edu\/user\/rachel-ringquist\u0022\u003ERachel Ringquist\u003C\/a\u003E, Roy\u2019s graduate student, and now a postdoctoral fellow with Singh, led the work as part of her doctoral dissertation.\u0026nbsp;\u003Cbr\u003E\u003Cbr\u003E\u201cThat was the \u2018wow\u2019 moment,\u201d Singh said. \u201cIt was the first time we felt we had something close to a real human lung.\u201d\u003C\/p\u003E\u003Cp\u003ELung-on-a-chip platforms provide researchers a window into organ behavior. They are about the size of a postage stamp, etched with tiny channels and lined with living human cells. Roy and Singh\u2019s innovation was adding a working immune system \u2014 the missing piece that turns a chip into a true model of how the lung fights disease.\u003C\/p\u003E\u003Cp\u003ENow, researchers can watch how lungs respond to threats, how inflammation spreads, and how healing begins.\u003Cbr\u003E\u0026nbsp;\u003C\/p\u003E\u003Ch4\u003E\u003Cstrong\u003EThe Human Stakes\u003C\/strong\u003E\u003C\/h4\u003E\u003Cp\u003EFor millions of people struggling with lung disease, everyday life can feel nearly impossible, whether it\u2019s climbing stairs, carrying groceries, or even laughing too hard. Doctors and scientists have attempted for decades to unlock what really happens inside fragile lungs.\u003C\/p\u003E\u003Cp\u003E\u0022This unique lung-on-a-chip model opens new, preclinical pathways of discovery that will allow researchers to better understand the interplay of immune responses to severe viral infections and evaluate critical antiviral treatments,\u201d said Roy.\u003C\/p\u003E\u003Cp\u003EFor Singh, the Carl Ring Family Professor in the \u003Ca href=\u0022https:\/\/www.me.gatech.edu\/\u0022\u003EGeorge W. Woodruff School of Mechanical Engineering\u003C\/a\u003E with a joint appointment in the \u003Ca href=\u0022https:\/\/bme.gatech.edu\/bme\/\u0022\u003EWallace H. Coulter Department of Biomedical Engineering\u003C\/a\u003E, this research is deeply personal. He lost an uncle when an infection overwhelmed his cancer-weakened immune system.\u003C\/p\u003E\u003Cp\u003E\u201cThat experience stays with you,\u201d Singh reflected. \u201cIt made me want to build systems that could predict and prevent outcomes like that, so fewer families go through what mine did. I think about my uncle all the time. If work like this means fewer families lose someone they love, then it\u2019s worth everything.\u201d\u003C\/p\u003E\u003Cp\u003EThat motivation pushed his team to reimagine what a lung-on-a-chip could do, setting the stage for the breakthroughs that followed.\u003Cbr\u003E\u0026nbsp;\u003C\/p\u003E\u003Ch4\u003E\u003Cstrong\u003EWhen the Lung Fought Back\u003C\/strong\u003E\u003C\/h4\u003E\u003Cp\u003EThe turning point came when Roy\u2019s and Singh\u2019s team peered through a microscope and saw something no one had ever witnessed on a chip: blood and immune cells coursing through tiny vessel-like structures, behaving just as they do in a living lung.\u003C\/p\u003E\u003Cp\u003EFor years, researchers had struggled to add immunity to organ-on-a-chip systems. Immune cells often died quickly or failed to circulate and interact with tissue the way they do in people. the team solved that problem, creating a chip where immune cells could survive and coordinate a defense.\u003C\/p\u003E\u003Cp\u003E\u201cIt was an amazing breakthrough moment,\u201d Singh said.\u003C\/p\u003E\u003Cp\u003EThe true test came when the team introduced a severe influenza virus infection. The lung mounted an immune response that closely mirrored what doctors see in patients. Immune cells rushed to the site of infection, inflammation spread through tissue, and defenses activated in response.\u003C\/p\u003E\u003Cp\u003E\u201cThat was when we realized this wasn\u2019t just a model,\u201d Singh said. \u201cIt was capturing the real biology of disease.\u201d\u003C\/p\u003E\u003Cp\u003ESingh and Roy\u2019s research is published in the journal \u003Ca href=\u0022https:\/\/www.nature.com\/articles\/s41551-025-01491-9\u0022\u003E\u003Cem\u003ENature Biomedical Engineering\u003C\/em\u003E\u003C\/a\u003E\u003Cem\u003E.\u003C\/em\u003E\u003Cbr\u003E\u0026nbsp;\u003C\/p\u003E\u003Ch4\u003E\u003Cstrong\u003EA More Human Approach\u003C\/strong\u003E\u003C\/h4\u003E\u003Cp\u003EFor decades, lung research has relied on animal models. But mice don\u2019t get asthma like children. Their bodies don\u2019t mount the same defenses.\u003C\/p\u003E\u003Cp\u003E\u201cFive mice in a cage may respond the same way, but five humans won\u2019t,\u201d Singh explained. \u201cOur chip can reflect that difference. That\u2019s what makes it more accurate, and why it could dramatically reduce the need for animal models.\u201d\u003C\/p\u003E\u003Cp\u003EKrish Roy emphasized its potential.\u003C\/p\u003E\u003Cp\u003E\u201cThe Food and Drug Administration\u2019s strategic vision on reducing animal testing and developing predictive non-animal models aligns perfectly with our work. This device goes further than ever before in modeling human severe influenza and providing unprecedented insights into the complex lung immune response,\u201d he said.\u003C\/p\u003E\u003Ch4\u003E\u003Cbr\u003E\u003Cstrong\u003EFighting More Than the Flu\u003C\/strong\u003E\u003C\/h4\u003E\u003Cp\u003EWhat began with influenza now expands to a wider range of diseases. Roy and Singh believes the platform can be used to study asthma, cystic fibrosis, lung cancer, and tuberculosis. The researchers are also working to integrate immune organs, showing how the lung coordinates with the body\u2019s defenses.\u003C\/p\u003E\u003Cp\u003EThe long-term vision is personalized medicine: chips built from a patient\u2019s own cells to predict which therapy will work best. Scaling, clinical validation, and regulatory approval will take years, but Singh is undeterred.\u003C\/p\u003E\u003Cp\u003E\u201cImagine knowing which treatment will help you before you ever take it,\u201d Singh said. \u201cThat\u2019s where we\u2019re headed.\u201d\u003C\/p\u003E\u003Cp\u003EWhere we\u2019re headed, the future doesn\u2019t wait for illness. Instead, it anticipates it, intercepts it, and rewrites the outcome.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cem\u003EGeorgia Tech postdoctoral researcher Rachel Ringquist was the first author leading the study.\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cem\u003EThis research was supported by Wellcome Leap, with additional funding from the National Institutes of Health, Carl Ring Family Endowment, and the Marcus Foundation.\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cbr\u003ERingquist, R., Bhatia, E., Chatterjee, P.\u0026nbsp;\u003Cem\u003Eet al.\u003C\/em\u003E\u0026nbsp;An immune-competent lung-on-a-chip for modelling the human severe influenza infection response.\u0026nbsp;\u003Cem\u003ENature Biomedical Engineering,\u0026nbsp;\u003C\/em\u003ESeptember 2025 Vol.9 No.9\u003C\/p\u003E\u003Cp\u003EDOI:\u0026nbsp;\u003Ca href=\u0022https:\/\/www.nature.com\/articles\/s41551-025-01491-9#citeas\u0022\u003Ehttps:\/\/doi.org\/10.1038\/s41551-025-01491-9\u003C\/a\u003E\u003C\/p\u003E","summary":"","format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EGeorgia Tech and Vanderbilt researchers have developed the first lung-on-a-chip with a functioning immune system, a breakthrough published in \u003Cem\u003ENature Biomedical Engineering\u003C\/em\u003E. Led by Ankur Singh and Krishnendu \u201cKrish\u201d Roy, the team created a postage stamp-sized device where blood and immune cells circulate, fight infection, and heal, just as they would in a living lung. The advance not only provides unprecedented insight into diseases like influenza, asthma, and cancer but also offers a path toward reducing animal testing. Long-term, the technology could enable personalized medicine, with chips built from patients\u2019 own cells to predict which therapies will work best.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Georgia Tech and Vanderbilt researchers have built the first lung-on-a-chip with a working immune system, a breakthrough with the potential to reshape how we study disease, move beyond animal testing, and administer lifesaving therapies."}],"uid":"36410","created_gmt":"2025-09-24 15:20:56","changed_gmt":"2025-12-10 16:49:57","author":"mazriel3","boilerplate_text":"","field_publication":"","field_article_url":"","location":"Atlanta, GA","dateline":{"date":"2025-09-24T00:00:00-04:00","iso_date":"2025-09-24T00:00:00-04:00","tz":"America\/New_York"},"extras":[],"hg_media":{"678118":{"id":"678118","type":"image","title":"Lung-on-a-Chip With Immune System","body":"\u003Cp\u003EAnkur Singh and Rachel Ringquist point to the microscopic lung-on-a-chip that has a built-in immune system.\u003C\/p\u003E","created":"1758725634","gmt_created":"2025-09-24 14:53:54","changed":"1758726945","gmt_changed":"2025-09-24 15:15:45","alt":"Researchers show off a lung-on-a-chip that has an immune system. Long term, this technology could lead to highly personalized medicine","file":{"fid":"262102","name":"20250911_IBB_ChipLung-01.jpg","image_path":"\/sites\/default\/files\/2025\/09\/24\/20250911_IBB_ChipLung-01.jpg","image_full_path":"http:\/\/hg.gatech.edu\/\/sites\/default\/files\/2025\/09\/24\/20250911_IBB_ChipLung-01.jpg","mime":"image\/jpeg","size":13303952,"path_740":"http:\/\/hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/2025\/09\/24\/20250911_IBB_ChipLung-01.jpg?itok=oU9qxbUs"}}},"media_ids":["678118"],"groups":[{"id":"660369","name":"Matter and Systems"},{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"},{"id":"1188","name":"Research Horizons"}],"categories":[{"id":"138","name":"Biotechnology, Health, Bioengineering, Genetics"}],"keywords":[{"id":"187915","name":"go-researchnews"},{"id":"1613","name":"Biomedical Engieering"},{"id":"98751","name":"College of Engineering; George W. Woodruff School of Mechanical Engineering"},{"id":"187423","name":"go-bio"}],"core_research_areas":[{"id":"39441","name":"Bioengineering and Bioscience"},{"id":"193652","name":"Matter and Systems"}],"news_room_topics":[{"id":"71891","name":"Health and Medicine"}],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EMichelle Azriel Sr. Writer-Editor\u003C\/p\u003E","format":"limited_html"}],"email":["mazriel3@gatech.edu"],"slides":[],"orientation":[],"userdata":""}}}