{"683862":{"#nid":"683862","#data":{"type":"event","title":"PhD Proposal by Shaylyn Grier","body":[{"value":"\u003Cp\u003EShaylyn Grier\u003Cbr\u003EBME PhD Proposal Presentation\u003Cbr\u003E\u003Cbr\u003E\u003Cstrong\u003EDate\u003C\/strong\u003E: 2025-08-22\u003Cbr\u003E\u003Cstrong\u003ETime\u003C\/strong\u003E: 10:00AM-12:00PM EST\u003Cbr\u003E\u003Cstrong\u003ELocation \/ Meeting Link\u003C\/strong\u003E: IBB Suddath Seminar Room (IBB 1128); Zoom Link:\u0026nbsp;\u003Cbr\u003E\u003Cbr\u003E\u003Cstrong\u003ECommittee Members:\u003C\/strong\u003E\u003Cbr\u003EAnkur Singh, PhD (Advisor); Melissa Kemp, PhD; Tara Deans, PhD; Krishnendu Roy, PhD; Todd Sulchek, PhD\u003Cbr\u003E\u003Cbr\u003E\u003Cbr\u003E\u003Cstrong\u003ETitle\u003C\/strong\u003E: Cationic nanowires for microRNA-driven differentiation of progenitor exhausted T cells\u003Cbr\u003E\u003Cbr\u003E\u003Cstrong\u003EAbstract:\u003C\/strong\u003E\u003Cbr\u003EPersistent antigen exposure in solid tumors and chronic infections drives CD8+ T cell exhaustion, characterized by impaired function and expression of inhibitory receptors. A stem-like subset called progenitor exhausted T cells (Texprog) sustains immune responses and predicts better outcomes with immune checkpoint blockade (ICB). However, Texprog levels vary widely among patients, limiting therapeutic consistency. We propose engineering nanowire technology to program na\u00efve CD8+ T cells ex vivo into the Texprog state to produce defined, potent therapies independent of endogenous levels. Overall, my proposed research aims to establish Texprog cells as a durable, clinically relevant subset and demonstrate nanowire-mediated engineering as a promising strategy for next-generation cancer immunotherapy development.\u003C\/p\u003E","summary":"","format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003ECationic nanowires for microRNA-driven differentiation of progenitor exhausted T cells\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Cationic nanowires for microRNA-driven differentiation of progenitor exhausted T cells"}],"uid":"27707","created_gmt":"2025-08-15 18:09:09","changed_gmt":"2025-08-15 18:09:09","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2025-08-22T10:00:01-04:00","event_time_end":"2025-08-22T12:00:00-04:00","event_time_end_last":"2025-08-22T12:00:00-04:00","gmt_time_start":"2025-08-22 14:00:01","gmt_time_end":"2025-08-22 16:00:00","gmt_time_end_last":"2025-08-22 16:00:00","rrule":null,"timezone":"America\/New_York"},"location":"IBB Suddath Seminar Room (IBB 1128); Zoom Link","extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"102851","name":"Phd proposal"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78771","name":"Public"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}