{"683483":{"#nid":"683483","#data":{"type":"event","title":"BioE PhD Proposal Presentation-  Glory Onajobi-Lee","body":[{"value":"\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EAdvisor:\u0026nbsp;\u003C\/strong\u003ECorey J. Wilson, Ph.D. (School of Chemical and Biomolecular Engineering, Georgia Tech)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee Members:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EJohn J. Blazeck, Ph.D. (School of Chemical and Biomolecular Engineering, Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003EMatthew J. Realff, Ph.D. (School of Chemical and Biomolecular Engineering, Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003EKarmella Haynes, Ph.D. (Department of Biomedical Engineering, Emory University)\u003C\/p\u003E\u003Cp\u003EThomas J. DiChristina, Ph.D. (School of Biological Sciences, Georgia Institute of Technology)\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EExpanding Transcriptional Programming Wetware and Biocomputing Capacity\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003ESynthetic biology aims to engineer cells with programmable behaviors by designing gene circuits that process information and respond to environmental cues. This thesis advances the Transcriptional Programming (T-Pro) platform through the development of novel anti-repressor biosensors and related software to enable scalable biocomputing capacity. In \u003Cstrong\u003EAim 1\u003C\/strong\u003E, novel anti-repressor variants from the LacI\/GalR family will be engineered to expand the regulatory toolkit available for constructing modular and orthogonal gene circuits. \u003Cstrong\u003EAim 2\u003C\/strong\u003E\u0026nbsp;will\u0026nbsp;focus on the development of a computational framework for designing compressed higher-order genetic circuits that leverage anti-repressor biosensors developed in \u003Cstrong\u003EAim 1\u003C\/strong\u003E. The envisioned software will translate user-defined multi-input truth tables into compressed circuit architectures for \u0026gt;3-input Boolean operations. \u003Cstrong\u003EAim 3\u003C\/strong\u003E\u0026nbsp;will apply the resulting wetware toward the development of novel biological security systems. Collectively, this work will increase T-Pro\u2019s biocomputing capacity and enhance wetware applications in the context of biocontainment.\u003C\/p\u003E","summary":"","format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioE PhD Proposal Presentation- \u0026nbsp;\u0022Expanding Transcriptional Programming Wetware and Biocomputing Capacity\u0022 -Glory Onajobi-Lee\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Expanding Transcriptional Programming Wetware and Biocomputing Capacity\u0022"}],"uid":"27917","created_gmt":"2025-08-01 19:11:17","changed_gmt":"2025-08-01 19:12:22","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2025-08-14T14:00:00-04:00","event_time_end":"2025-08-14T16:00:00-04:00","event_time_end_last":"2025-08-14T16:00:00-04:00","gmt_time_start":"2025-08-14 18:00:00","gmt_time_end":"2025-08-14 20:00:00","gmt_time_end_last":"2025-08-14 20:00:00","rrule":null,"timezone":"America\/New_York"},"location":"4029 EBB","extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"172056","name":"go-BioE"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}