{"682129":{"#nid":"682129","#data":{"type":"news","title":"A New Frontier of Immune Research: Andrew McShan Awarded CAREER Grant for Protein-Lipid Research","body":[{"value":"\u003Cp dir=\u0022ltr\u0022\u003EImagine unlocking universal immunotherapies and cancer treatments, powerful vaccines, and a deeper understanding of our own immune systems. Georgia Tech\u2019s\u0026nbsp;\u003Ca href=\u0022https:\/\/chemistry.gatech.edu\/people\/andrew-mcshan\u0022\u003E\u003Cstrong\u003EAndrew McShan\u003C\/strong\u003E\u003C\/a\u003E is laying the groundwork for these innovations by investigating the previously understudied field of lipids, and how they interact with proteins in the body.\u003C\/p\u003E\u003Cp dir=\u0022ltr\u0022\u003EMcShan, an assistant professor in the\u0026nbsp;\u003Ca href=\u0022https:\/\/chemistry.gatech.edu\/\u0022\u003ESchool of Chemistry and Biochemistry\u003C\/a\u003E, has been awarded a\u0026nbsp;\u003Ca href=\u0022https:\/\/www.nsf.gov\/awardsearch\/showAward?AWD_ID=2442018\u0026amp;HistoricalAwards=false\u0022\u003E$1.4 million CAREER grant from the National Science Foundation\u0026nbsp;\u003C\/a\u003E(NSF) to support this research.\u003C\/p\u003E\u003Cp dir=\u0022ltr\u0022\u003E\u201cProtein-lipid assemblies carry out all sorts of biological functions, and harnessing their interactions could lead to powerful tools and treatments\u0026nbsp;\u2014\u0026nbsp;but historically, they\u2019ve been difficult to study,\u201d McShan says. \u201cBuilding resources for researchers and making this information accessible are critical steps in developing this field. This CAREER grant will enable me to expand the current knowledge base, while also allowing me to develop a class that will train the next generation of researchers, which is hugely important to me.\u201d\u003C\/p\u003E\u003Cp dir=\u0022ltr\u0022\u003EThe NSF Faculty Early Career Development Program is a five-year grant designed to help promising researchers establish a foundation for a lifetime of leadership in their field. Known as CAREER awards, the grants are NSF\u2019s most prestigious funding for early-career faculty.\u003C\/p\u003E\u003Ch3\u003E\u003Cstrong\u003EExpanding access\u003C\/strong\u003E\u003C\/h3\u003E\u003Cp dir=\u0022ltr\u0022\u003ECrucial for nearly all biological processes, lipid-protein interactions play a key role in everything from immune responses to energy storage \u2014 but\u0026nbsp;what drives their interactions has historically been difficult to map and understand.\u003C\/p\u003E\u003Cp dir=\u0022ltr\u0022\u003EMcShan will use the CAREER grant to expand that knowledge base, experimenting in the lab to characterize protein-lipid interactions, and developing computational tools that can predict those interactions. The work will include an in-depth study of how lipids interact with different families of proteins that are important for immune system function.\u003C\/p\u003E\u003Cp dir=\u0022ltr\u0022\u003E\u201cRight now, understanding protein-lipid assemblies is expensive in both time and lab materials,\u201d McShan says. \u201cMy goal is to create computer models that can predict how these biomolecular interactions occur, what they look like, and how they contribute to cellular functions.\u201d\u003C\/p\u003E\u003Cp dir=\u0022ltr\u0022\u003EThe new model would allow researchers to quickly and inexpensively \u2018experiment\u2019 with molecules on a computer, vastly expanding the amount of research that could be conducted.\u0026nbsp;\u003C\/p\u003E\u003Cp dir=\u0022ltr\u0022\u003EThe project builds on McShan\u2019s\u0026nbsp;\u003Ca href=\u0022https:\/\/www.nature.com\/articles\/s42004-024-01384-z\u0022\u003Erecent publication\u003C\/a\u003E in the\u0026nbsp;\u003Cem\u003ENature\u003C\/em\u003E-family journal\u0026nbsp;\u003Cem\u003ECommunications Chemistry\u003C\/em\u003E, which showcased\u0026nbsp;\u003Ca href=\u0022https:\/\/cos.gatech.edu\/news\/new-database-revolutionizes-protein-lipid-research\u0022\u003EBioDolphin \u2014 a first-of-its-kind, comprehensive, and annotated database\u003C\/a\u003E of protein-lipid interactions that are all integrated into a user-friendly web server and\u0026nbsp;\u003Ca href=\u0022https:\/\/biodolphin.chemistry.gatech.edu\/\u0022\u003Efreely accessible to all\u003C\/a\u003E.\u0026nbsp;\u003C\/p\u003E\u003Cp dir=\u0022ltr\u0022\u003EIt\u2019s also adjacent to research funded by a Curci Grant from the Shurl and Kay Curci Foundation, which McShan was previously awarded\u0026nbsp;\u003Ca href=\u0022https:\/\/cos.gatech.edu\/news\/andrew-mcshan-awarded-curci-grant-cutting-edge-cancer-research\u0022\u003Efor research on cutting-edge cancer treatments\u003C\/a\u003E that involved identifying new cancer lipid signatures in tumor cells, and characterizing known cancer lipid antigens.\u003C\/p\u003E\u003Ch3\u003E\u003Cstrong\u003EPioneering the future of research\u003C\/strong\u003E\u003C\/h3\u003E\u003Cp dir=\u0022ltr\u0022\u003EAdditionally, the CAREER grant will support McShan\u2019s initiatives to train the next generation of researchers through a new class centered around hands-on laboratory research and peer mentorship. Students will have the opportunity to pick a protein-lipid assembly, study it using computational and experimental biophysical methods, develop testable hypotheses, and\u0026nbsp;\u2014 if successful\u0026nbsp;\u2014 publish their results in peer reviewed journals.\u003C\/p\u003E\u003Cp dir=\u0022ltr\u0022\u003EThe class will also pair undergraduate and graduate students into research teams. \u201cI\u2019m excited to see how a peer mentoring approach will add depth to the class,\u201d McShan shares, explaining that graduate students will gain valuable mentoring experience in a collaborative research environment. \u201cThis is very different from typical mentoring experiences many graduate students have, which tend to be more along the lines of a TA experience rather than collaborating on hands-on research.\u201d\u003C\/p\u003E\u003Cp\u003E\u201cThis type of class, to my knowledge, hasn\u2019t been offered before, and there\u2019s a lot of research that I\u2019m doing to lay the groundwork for it,\u201d McShan adds. \u201cHopefully, it can not only introduce students to lipid-based research\u0026nbsp;\u2014 something typically lacking in many biochemistry curricula\u0026nbsp;\u2014 but also to the type of collaborative mentorship we want to foster in research.\u201d\u003C\/p\u003E","summary":"","format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EAndrew McShan has been awarded a\u0026nbsp;$1.4M NSF CAREER grant to research lipids, and how they interact with proteins in the body. Lipid-protein interactions play a key role in everything from immune responses to energy storage \u2014 and could be the key to unlocking universal immunotherapies and cancer treatments, powerful vaccines, and a deeper understanding of our own immune systems.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Andrew McShan has been awarded a\u00a0$1.4M NSF CAREER grant to research lipids, and how they interact with proteins in the body."}],"uid":"35599","created_gmt":"2025-04-30 14:11:41","changed_gmt":"2025-04-30 14:23:32","author":"sperrin6","boilerplate_text":"","field_publication":"","field_article_url":"","location":"Atlanta, GA","dateline":{"date":"2025-04-30T00:00:00-04:00","iso_date":"2025-04-30T00:00:00-04:00","tz":"America\/New_York"},"extras":[],"hg_media":{"673456":{"id":"673456","type":"image","title":"Andrew McShan","body":null,"created":"1711032511","gmt_created":"2024-03-21 14:48:31","changed":"1711032492","gmt_changed":"2024-03-21 14:48:12","alt":"Andrew McShan","file":{"fid":"256854","name":"McShan_photo.jpeg","image_path":"\/sites\/default\/files\/2024\/03\/21\/McShan_photo.jpeg","image_full_path":"http:\/\/hg.gatech.edu\/\/sites\/default\/files\/2024\/03\/21\/McShan_photo.jpeg","mime":"image\/jpeg","size":96566,"path_740":"http:\/\/hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/2024\/03\/21\/McShan_photo.jpeg?itok=aCepzxdB"}}},"media_ids":["673456"],"groups":[{"id":"1278","name":"College of Sciences"},{"id":"85951","name":"School of Chemistry and Biochemistry"}],"categories":[{"id":"138","name":"Biotechnology, Health, Bioengineering, Genetics"},{"id":"140","name":"Cancer Research"},{"id":"141","name":"Chemistry and Chemical Engineering"},{"id":"146","name":"Life Sciences and Biology"},{"id":"135","name":"Research"}],"keywords":[{"id":"192249","name":"cos-community"},{"id":"192250","name":"cos-microbial"}],"core_research_areas":[{"id":"39441","name":"Bioengineering and Bioscience"},{"id":"193653","name":"Georgia Tech Research Institute"}],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EWritten by Selena Langner\u003C\/p\u003E\u003Cp\u003EContact: \u003Ca href=\u0022mailto: jess.hunt@cos.gatech.edu\u0022\u003EJess Hunt-Ralston\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}