{"681710":{"#nid":"681710","#data":{"type":"event","title":"Bioengineering Seminar","body":[{"value":"\u003Cp\u003E\u003Cbr\u003E\u003Cem\u003ECo-hosted by Georgia Tech\u0027s Institute for Bioengineering and Bioscience and the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University.\u003C\/em\u003E\u003Cbr\u003E\u003Cbr\u003E\u003Ca href=\u0022https:\/\/www.germinal.center\/\u0022\u003EGabriel D. Victora\u003C\/a\u003E\u003Cbr\u003ELaurie and Peter Grauer Professor\u003Cbr\u003EInvestigator, Howard Hughes Medical Institute\u003Cbr\u003EThe Rockefeller University\u003Cbr\u003E\u003Cbr\u003E\u003Cstrong\u003E**\u003C\/strong\u003E\u003Ca href=\u0022https:\/\/gatech.zoom.us\/webinar\/register\/WN_QHJxjN-oRl6LICc7RsbK7Q\u0022\u003E\u003Cstrong\u003ERegister HERE\u003C\/strong\u003E\u003C\/a\u003E\u003Cstrong\u003E to attend virtually\u003C\/strong\u003E\u003Cbr\u003E\u003Cbr\u003EABSTRACT\u003Cbr\u003EThe average affinity of specific antibodies increases dramatically over the course of an immune response. This increase is the result of a Darwinian process in which B lymphocytes undergo iterative cycles of random hypermutation of their immunoglobulin genes, followed by selective proliferation of clones bearing affinity-enhancing mutations. This evolutionary process takes place in highly dynamic microanatomical structures known as germinal centers, which arise within secondary lymphoid organs upon infection or immunization. Our work combines intravital multiphoton microscopy with mouse genetics to study how the dynamics of B and T lymphocytes within germinal centers shapes the evolution of the high-affinity antibodies that are crucial to protection from infectious disease.\u003C\/p\u003E\u003Cp\u003ERESEARCH\u003Cbr\u003EThe Victora lab works mostly on B lymphocytes, the cells that produce the antibodies that protect us against infectious diseases. By combining traditional immunology, mouse genetics, and multiphoton microscopy, they investigate the regulation of B lymphocyte activation and differentiation and the process of antibody affinity maturation. They also do a bit of work on cell-cell interactions in general on the side.\u003Cbr\u003E\u003Cbr\u003E\u003Ca href=\u0022https:\/\/research.gatech.edu\/bio\/events\/bioengineering-seminar-series\u0022\u003E\u003Cstrong\u003EView Full 2025-2026 Bioengineering Seminar Series Schedule\u003C\/strong\u003E\u003C\/a\u003E\u003C\/p\u003E","summary":"","format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E\u0022Replaying Germinal Center Evolution\u0022 - Gabriel D. Victora - The Rockefeller University\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Replaying Germinal Center Evolution\u0022 - Gabriel D. Victora - The Rockefeller University"}],"uid":"27195","created_gmt":"2025-04-10 11:47:17","changed_gmt":"2025-08-25 14:20:08","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2025-09-16T11:00:00-04:00","event_time_end":"2025-09-16T12:00:00-04:00","event_time_end_last":"2025-09-16T12:00:00-04:00","gmt_time_start":"2025-09-16 15:00:00","gmt_time_end":"2025-09-16 16:00:00","gmt_time_end_last":"2025-09-16 16:00:00","rrule":null,"timezone":"America\/New_York"},"location":"Petit Biotechnology Building, 315 Ferst Drive, NW, Suddath Seminar Room 1128, Atlanta, GA 30332","extras":[],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"},{"id":"1254","name":"Wallace H. Coulter Dept. of Biomedical Engineering"}],"categories":[],"keywords":[{"id":"187423","name":"go-bio"},{"id":"188124","name":"go-bioe-seminar"},{"id":"189814","name":"go-researchevents"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"177814","name":"Postdoc"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EFaculty host: \u003Ca href=\u0022mailto:ankur.singh@me.gatech.edu\u0022\u003EAnkur Singh\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}