678908 external_news 1734373207 1734456535 <![CDATA[BioDolphin as a comprehensive database of lipid–protein binding interactions]]> Lipid-protein interactions are crucial for virtually all biological processes in living cells. However, existing structural databases focusing on these interactions are limited to integral membrane proteins. A systematic understanding of diverse lipid-protein interactions also encompassing lipid-anchored, peripheral membrane and soluble lipid binding proteins remains to be elucidated. 

To address this gap and facilitate the research of universal lipid-protein assemblies, researchers including School of Chemistry and Biochemistry Assistant Professor Andrew C. McShan developed BioDolphin — a curated database with over 127,000 lipid-protein interactions. BioDolphin provides comprehensive annotations, including protein functions, protein families, lipid classifications, lipid-protein binding affinities, membrane association type, and atomic structures.

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