{"678532":{"#nid":"678532","#data":{"type":"event","title":"Coulter BME Seminar Series: Laura Segatori, Ph.D.","body":[{"value":"\u003Cdiv\u003E\u003Cp\u003E\u003Cstrong\u003ELunch at 12:30pm in\u0026nbsp;HSRB II, N100\u0026nbsp;before the seminar.\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003C\/div\u003E\u003Cp\u003ELaura Segatori, Ph.D\u003Cbr\u003EProfessor at Rice University, Departments of Bioengineering, Chemical and Biomolecular\u0026nbsp;Engineering, and Biosciences\u0026nbsp;\u003C\/p\u003E\u003Cp\u003ENov. 15, 1 p.m.\u003Cbr\u003EHSRB II, N100\u0026nbsp;\u003C\/p\u003E\u003Cp\u003ECannot attend in person? Join us via the Zoom virtual meeting link:\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EMeeting ID: 974 2121 9805\u003C\/p\u003E\u003Cp\u003EPassword: 556677\u003C\/p\u003E\u003Cdiv\u003E\u003Cp\u003E\u003Ca href=\u0022https:\/\/zoom.us\/j\/97421219805?pwd=b2ZUZElTQ044anlVbFRib2VIQk1IQT09\u0022 id=\u0022LPlnkOWAcaf64e69-a4fa-9150-75e6-4759b574d58d\u0022 rel=\u0022noopener noreferrer\u0022 target=\u0022_blank\u0022 title=\u0022https:\/\/zoom.us\/j\/97421219805?pwd=b2ZUZElTQ044anlVbFRib2VIQk1IQT09\u0022\u003Ehttps:\/\/zoom.us\/j\/97421219805?pwd=b2ZUZElTQ044anlVbFRib2VIQk1IQT09\u003C\/a\u003E\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv\u003E\u003Cp\u003EDial by your location: +1 470 381 2552 US (Atlanta)\u0026nbsp;\u003C\/p\u003E\u003C\/div\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ETitle:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EProgramming cellular sensors with genetic control systems\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EAbstract:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EProgress in synthetic biology has enabled the construction of designer cells that sense biological inputs and, in response, activate user-defined biomolecular programs. Such engineered cells provide unique opportunities for treating a wide variety of diseases. Current strategies mostly rely on cell-surface receptor systems engineered to convert binding interactions into activation of a transcriptional program. Genetic control systems are emerging as an appealing alternative to receptor-based sensors as they overcome the need for receptor engineering and result in cellular behaviors that operate over therapeutically relevant timescales. Genetic control systems include synthetic gene networks, RNA-based sensors, and post-translational tools. These technologies present fundamental challenges, including precise integration with innate pathways, the need for parts orthogonal to existing circuitries, and the metabolic burden induced by such complex cell engineering endeavors. Through iterations of experimental measurements and predictive modeling, we developed a platform technology for quantitative, multiplexed profiling of gene expression signatures with high sensitivity and dynamic resolution. This talk describes efforts to deploy this\u0026nbsp;technology to design cellular sensors with exquisite feedback control systems for cell therapies and biomanufacturing applications.\u003C\/p\u003E","summary":"","format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EHear from faculty about the latest in biomedical research.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Topic: Programming cellular sensors with genetic control systems"}],"uid":"35963","created_gmt":"2024-11-19 18:37:38","changed_gmt":"2024-11-19 18:39:20","author":"kpetty30","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2024-11-15T13:00:00-05:00","event_time_end":"2024-11-15T14:00:00-05:00","event_time_end_last":"2024-11-15T14:00:00-05:00","gmt_time_start":"2024-11-15 18:00:00","gmt_time_end":"2024-11-15 19:00:00","gmt_time_end_last":"2024-11-15 19:00:00","rrule":null,"timezone":"America\/New_York"},"location":"Emory University HSRB II, N100","extras":["free_food"],"hg_media":{"675668":{"id":"675668","type":"image","title":"BME-coulter-bme-seminar-nov-15-laura-segatori.jpg","body":null,"created":"1732041520","gmt_created":"2024-11-19 18:38:40","changed":"1732041520","gmt_changed":"2024-11-19 18:38:40","alt":"Flyer with image of speaker Laura Segatori at top of page with event details.","file":{"fid":"259318","name":"BME-coulter-bme-seminar-nov-15.jpg","image_path":"\/sites\/default\/files\/2024\/11\/19\/BME-coulter-bme-seminar-nov-15.jpg","image_full_path":"http:\/\/hg.gatech.edu\/\/sites\/default\/files\/2024\/11\/19\/BME-coulter-bme-seminar-nov-15.jpg","mime":"image\/jpeg","size":186083,"path_740":"http:\/\/hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/2024\/11\/19\/BME-coulter-bme-seminar-nov-15.jpg?itok=8BfQQIy_"}}},"media_ids":["675668"],"groups":[{"id":"1254","name":"Wallace H. Coulter Dept. of Biomedical Engineering"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}