{"677942":{"#nid":"677942","#data":{"type":"event","title":"MS Proposal by Avik Banerjee","body":[{"value":"\u003Cp\u003EAvik Banerjee\u003Cbr\u003E[Advisor: Prof. Christopher Carr] will propose a master\u2019s thesis entitled,\u003Cbr\u003ESoftware Architecture Development of Single Molecule Detection\u003Cbr\u003EInstrumentation for Astrobiology Exploration\u003Cbr\u003EOn\u003Cbr\u003EFriday, November 1st at 9:00 a.m.\u003Cbr\u003EEngineering Science \u0026amp; Mechanics Building 108\u003Cbr\u003EAbstract\u003C\/p\u003E\u003Cp\u003EA primary goal of planetary exploration is the search for life beyond Earth, particularly by\u0026nbsp;\u003Cbr\u003Edetecting biomolecular signatures on celestial bodies like Europa and Enceladus, which may have the\u0026nbsp;\u003Cbr\u003Econditions to support life. The Electronic Life-detection Instrument for Europa\/Enceladus (ELIE) is\u0026nbsp;\u003Cbr\u003Edesigned to detect amino acids, RNA, DNA, and other charged polymers indicative of life. Based on\u0026nbsp;\u003Cbr\u003Ethe benchtop nanogap detection technology developed by Osaka University, the original ELIE\u0026nbsp;\u003Cbr\u003Eprototype successfully demonstrated the detection of single molecules in a zero-g flight. However,\u0026nbsp;\u003Cbr\u003Ethis system was relatively large and required manual operations such as chip loading and cleaning.\u0026nbsp;\u003Cbr\u003EDesigned to address these limitations, the ELIE 2.0 prototype marked a significant improvement by\u0026nbsp;\u003Cbr\u003Ereducing the system\u2019s mass and volume and demonstrating the novel ability to monitor gap size\u0026nbsp;\u003Cbr\u003Eduring nanogap formation. ELIE 2.0 also laid the foundation for automated sample delivery and\u0026nbsp;\u003Cbr\u003Eelectrophoresis. Despite these advancements, ELIE 2.0 had critical issues relating to noise,\u0026nbsp;\u003Cbr\u003Eleading to the development of ELIE 3.0. ELIE 3.0 aims to address these challenges and increase the\u0026nbsp;\u003Cbr\u003Einstrument\u2019s TRL. This work focuses on developing software architecture to integrate new hardware,\u0026nbsp;\u003Cbr\u003Eincluding a new amplifier to enable multi-channel detection and control across the nanogap chip;\u0026nbsp;\u003Cbr\u003Eand a smaller vacuum-compatible piezoelectric actuator, requiring software modifications to\u0026nbsp;\u003Cbr\u003Eoptimize its performance. To improve precision detection, calibration scripts will be developed to\u0026nbsp;\u003Cbr\u003Efine-tune voltages across the E4 channels, ensuring minimal noise and maximum signal clarity.\u0026nbsp;\u003Cbr\u003EAdditionally, a centralized dispatch loop will automate key ELIE functions, accounting for each of\u0026nbsp;\u003Cbr\u003Etheir dependencies, and streamlining 30 \u03bcl sample delivery, gap formation and control, and sample\u0026nbsp;\u003Cbr\u003Emeasurement. All this functionality will be packaged into GUI software that provides user- friendly\u0026nbsp;\u003Cbr\u003Etesting and system operation. The ELIE 3.0 prototype will enable experiments that advance the\u0026nbsp;\u003Cbr\u003Einstrument hardware\/software from TRL 2 to TRL 4.\u003Cbr\u003ECommittee\u003Cbr\u003E\u2022 \u0026nbsp;Prof. Christopher Carr \u2013 School of Aerospace Engineering (advisor)\u003Cbr\u003E\u2022 \u0026nbsp;Prof. Masatoshi (Toshi) Hirabayashi \u2013 School of Aerospace Engineering\u003Cbr\u003E\u2022 \u0026nbsp;Prof. Brian Gunter \u2013 School of Aerospace Engineering\u003Cbr\u003E\u0026nbsp;\u003C\/p\u003E","summary":"","format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003ESoftware Architecture Development of Single Molecule Detection Instrumentation for Astrobiology Exploration\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Software Architecture Development of Single Molecule Detection Instrumentation for Astrobiology Exploration"}],"uid":"27707","created_gmt":"2024-10-28 17:47:15","changed_gmt":"2024-10-28 17:47:47","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2024-11-01T09:00:00-04:00","event_time_end":"2024-11-01T11:00:00-04:00","event_time_end_last":"2024-11-01T11:00:00-04:00","gmt_time_start":"2024-11-01 13:00:00","gmt_time_end":"2024-11-01 15:00:00","gmt_time_end_last":"2024-11-01 15:00:00","rrule":null,"timezone":"America\/New_York"},"location":"Engineering Science \u0026 Mechanics Building 108","extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"166866","name":"MS Proposal"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78771","name":"Public"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}