{"677938":{"#nid":"677938","#data":{"type":"news","title":"Ahmet Coskun Named CMBE Young Innovator for 2024","body":[{"value":"\u003Cdiv\u003E\u003Cdiv\u003E\u003Cdiv\u003E\u003Ca href=\u0022https:\/\/bme.gatech.edu\/bme\/sites\/default\/files\/2024-10\/Coskun1_0.jpg\u0022\u003E\u003Cimg src=\u0022https:\/\/bme.gatech.edu\/bme\/sites\/default\/files\/styles\/max_1300x1300\/public\/2024-10\/Coskun1_0.jpg?itok=JNN6kRgy\u0022 alt=\u0022Coskun with sample slide\u0022\u003E\u003C\/a\u003E\u003C\/div\u003E\u003Cdiv\u003E\u003Cdiv\u003E\u003Cp\u003ECoulter BME\u0027s Ahmet Coskun is a CMBE Young Innovator for his research into drug resistant cancers. \u0026nbsp; \u0026nbsp; \u0026nbsp; Photo by Jerry Grillo\u003C\/p\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv\u003E\u003Cdiv\u003E\u003Cdiv\u003E\u003Cdiv\u003E\u003Cdiv\u003E\u003Cp\u003E\u003Cstrong\u003EBy Jerry Grillo\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003ESome cancers are stubbornly resistant to the drugs designed to kill them, and \u003Ca href=\u0022https:\/\/bme.gatech.edu\/bme\/faculty\/Ahmet-F-Coskun\u0022\u003EAhmet Coskun\u003C\/a\u003E wants to know why. So, the Georgia Tech biomedical engineer and his research team has developed a precise molecular tool to help clear up the mystery.\u0026nbsp;\u003C\/p\u003E\u003Cp\u003ETheir graph-based super-resolution protein-protein interaction (GSR-PPI) technique creates a detailed, three-dimensional map of protein interactions within single cells. And it could lead to a better understanding and treatment of drug-resistant cancers.\u003C\/p\u003E\u003Cp\u003ECoskun will share the results of their work with the rest of the biomedical engineering world this week. As one of this year\u2019s 12 \u003Ca href=\u0022https:\/\/link.springer.com\/article\/10.1007\/s12195-024-00826-x\u0022\u003EYoung Innovators of Cellular and Molecular Bioengineering\u003C\/a\u003E (CMBE), he\u2019s been invited to present a \u003Ca href=\u0022https:\/\/link.springer.com\/article\/10.1007\/s12195-024-00822-1\u0022\u003Epaper about his research\u003C\/a\u003E on Friday, Oct. 25, at the 2024 Biomedical Engineering Society (BMES) \u003Ca href=\u0022https:\/\/www.bmes.org\/bmes2024\u0022\u003EAnnual Meeting\u003C\/a\u003E in Baltimore.\u003C\/p\u003E\u003Cp\u003E\u201cCancer treatments fail in many individuals and pinpointing what goes on at the single cell level is paramount,\u201d said Coskun, assistant professor in the Wallace H. Coulter Department of Biomedical Engineering, where he holds the Bernie Marcus Early Career Professorship.\u003C\/p\u003E\u003Cp\u003EHe noted that while sequencing and molecular imaging have shed light on the molecules associated with disease, there is no definitive test available to decode the communication between two interacting molecules that lead to drug resistance.\u003C\/p\u003E\u003Cp\u003E\u201cAt BMES we\u2019ll showcase a novel direction that creates a high-definition view of lung cancers in individual cells using a graphical representation of molecular wiring diagrams,\u201d he said.\u0026nbsp;\u003C\/p\u003E\u003Cp\u003ECurrent methods don\u2019t adequately capture the detailed spatial interactions of proteins in cells, which is crucial for understanding drug resistance. Coskun\u2019s team used single-cell spatial proximity ligation assays and advanced microscopy to examine protein interactions in lung cancer cells treated with the drug Osimertinib. Deep learning models analyzed these images to classify the drug treatment states of the cells.\u003C\/p\u003E\u003Cp\u003EGSR-PPI significantly outperformed the traditional methods in predicting how cells respond to the drug. It classified how drugs performed in both cancer cells and human lung tissues with high accuracy and differentiated between single and combination drug therapies.\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u201cBasically, it\u2019s like watching a 4k movie of cancer,\u201d said Coskun, the first person from Georgia Tech to receive the Young Innovator honor from CMBE, a leading research journal, in more than a decade.\u003C\/p\u003E\u003Cp\u003E\u201cGetting acknowledged by peers and mentors is an affirming feeling,\u201d he said. \u201cOur curiosity driven projects, and their translational impacts are being recognized. meets expectations. It\u2019s a sign of my group\u2019s passion to take chances and try new things.\u0022\u003C\/p\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E","summary":"","format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBiomedical engineer will present groundbreaking mapping tool aimed at drug resistant cancers at BMES Annual Meeting\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Biomedical engineer will present groundbreaking mapping tool aimed at drug resistant cancers at BMES Annual Meeting"}],"uid":"36454","created_gmt":"2024-10-28 16:06:27","changed_gmt":"2024-10-28 16:08:54","author":"swilliamson40","boilerplate_text":"","field_publication":"","field_article_url":"","dateline":{"date":"2024-10-24T00:00:00-04:00","iso_date":"2024-10-24T00:00:00-04:00","tz":"America\/New_York"},"extras":[],"related_links":[{"url":"https:\/\/bme.gatech.edu\/bme\/news\/ahmet-coskun-named-cmbe-young-innovator-2024","title":""}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[{"id":"138","name":"Biotechnology, Health, Bioengineering, Genetics"}],"keywords":[{"id":"187423","name":"go-bio"}],"core_research_areas":[{"id":"39441","name":"Bioengineering and Bioscience"}],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Cstrong\u003EBy Jerry Grillo\u003C\/strong\u003E\u003C\/p\u003E","format":"limited_html"}],"email":["jerry.grillo@ibb.gatech.edu"],"slides":[],"orientation":[],"userdata":""}}}