{"677937":{"#nid":"677937","#data":{"type":"news","title":"Andrei Fedorov and Collaborators Awarded $4.81 Million to Develop New Instrumentation for Biomedical Research ","body":[{"value":"\u003Cdiv\u003E\u003Cdiv\u003E\u003Cdiv\u003E\u003Cdiv\u003E\u003Cp\u003E\u003Ca href=\u0022https:\/\/me.gatech.edu\/faculty\/fedorov\u0022\u003E\u003Cstrong\u003EAndrei Fedorov\u003C\/strong\u003E\u003C\/a\u003E, Associate Chair for Graduate Studies, Rae S. and Frank H. Neely Chair, and professor in the George W. Woodruff School of Mechanical Engineering, has received two Research Project Grants (R01) from the National Institutes of Health (NIH).\u003C\/p\u003E\u003Cp\u003EThe funding, a combined $4.81 million to be distributed over the next five years, will be used to develop new instrumentation for biomedical research.\u003Cbr\u003E\u0026nbsp;\u0026nbsp;\u003C\/p\u003E\u003Ch4\u003E\u003Cstrong\u003EGuided Intracellular Delivery using Precise Area Introduction and Transfection (PAINT)\u003C\/strong\u003E\u003C\/h4\u003E\u003Cp\u003EThe first project, supported by $1.87 million from the National Institute of General Medical Sciences (NIGMS), aims to develop a new method for highly localized, versatile, and efficient biochemical delivery for \u0022direct-write\u0022 guided administration at single-cell to multi-cell resolution. PAINT permits the simple and quick production of heterogeneously modified samples, including in vitro cell and tissue cultures.\u003C\/p\u003E\u003Cp\u003EModifying cells by introducing biomolecules has become a critical process for fundamental biomedical research and is gaining traction as a treatment approach. This project will provide a significant leap forward in the capability and utility of microinjection and other state-of-the-art delivery methods.\u003C\/p\u003E\u003Cp\u003EThis novel approach to cell modification, invented in Fedorov\u2019s lab, is primarily based on its versatility, ease of use, and rapidity. As PAINT modification of cells does not require direct contact, several steps of the cargo introduction process for micro-injection are eliminated, allowing for continuous, more straightforward cell modification.\u003C\/p\u003E\u003Cp\u003EThis project is a collaboration with Professor \u003Ca href=\u0022https:\/\/www.chbe.gatech.edu\/directory\/person\/ravi-kane\u0022\u003E\u003Cstrong\u003ERavi Kane\u003C\/strong\u003E\u003C\/a\u003E from the \u003Ca href=\u0022https:\/\/www.chbe.gatech.edu\/\u0022\u003E\u003Cstrong\u003ESchool of Chemical and Biomolecular Engineering\u003C\/strong\u003E\u003C\/a\u003E and Professor Randolph Ashton from the University of Wisconsin.\u003Cbr\u003E\u0026nbsp;\u003C\/p\u003E\u003Ch4\u003E\u003Cstrong\u003ESynergistic Advancements in MR Thermometry and Predictive Thermal Modeling Towards Improved Characterization of Human Brain Temperature\u003C\/strong\u003E\u003C\/h4\u003E\u003Cp\u003EThe second project, supported by $2.94 million from the National Institute of Neurological Disorders and Stroke, aims to develop non-invasive, repeatable, in vivo magnetic resonance (MR) brain thermometry and a novel, quantitative, hemodynamic biophysical model for interpreting MR images and predicting brain temperature.\u003C\/p\u003E\u003Cp\u003E\u0022Brain thermoregulation is a poorly understood but critical modulator of neural activity and hemodynamics,\u0022 said Fedorov. Though brain and body temperatures are highly correlated indicators of health, the way the body regulates them is distinct. Brain temperature fluctuations can contribute to ischemia-induced brain damage and mortality after traumatic brain injury.\u003C\/p\u003E\u003Cp\u003EThe project will leverage the expertise in MR thermometry, thermal modeling, clinical neurology, and neuroradiology to facilitate the development of clinically viable methods for in vivo brain thermometry and temperature predictions, provide mechanistic insight into brain thermoregulation, and identify urgently needed biomarkers for injury and neuroprotection.\u003C\/p\u003E\u003Cp\u003EThis interdisciplinary project is a long-term collaboration with \u003Ca href=\u0022https:\/\/bme.gatech.edu\/bme\/faculty\/Candace-Fleischer\u0022\u003E\u003Cstrong\u003ECandace Fleischer\u003C\/strong\u003E\u003C\/a\u003E, associate professor in the Department of Radiology at Emory University School of Medicine and assistant professor in the \u003Ca href=\u0022https:\/\/bme.gatech.edu\/bme\/\u0022\u003E\u003Cstrong\u003EWallace H. Coulter Department of Biomedical Engineering at Emory University and Georgia Tech\u003C\/strong\u003E\u003C\/a\u003E.\u003C\/p\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp\u003E\u003Cimg src=\u0022https:\/\/me.gatech.edu\/sites\/default\/files\/2024-10\/Fedorov_R01.png\u0022 alt=\u0022Malik McRae (front) and Ire Adaramola (back) are conducting experiments with the early prototype of the PAINT device for \u0026quot;direct-write\u0026quot; guided drug delivery to biological cells.\u0022 width=\u0022907\u0022 height=\u00221128\u0022\u003E\u003C\/p\u003E\u003Cdiv\u003E\u003Cdiv\u003E\u003Cdiv\u003E\u003Cdiv\u003E\u003Cdiv\u003E\u003Cp\u003E\u003Cem\u003EMalik McRae (front) and Ire Adaramola (back) are conducting experiments with the early prototype of the PAINT device for \u0022direct-write\u0022 guided drug delivery to biological cells. McRae, a Morehouse College student and a Petit Scholar in Bioengineering in the Fedorov laboratory, won the Marshall Fellowship for his research and is currently pursuing his MD\/Ph.D. at the Johns Hopkins School of Medicine. Adaramola is completing the first year of her master\u2019s degree in mechanical engineering at the Woodruff School.\u003C\/em\u003E\u003C\/p\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E","summary":"","format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E\u003Ca href=\u0022https:\/\/me.gatech.edu\/faculty\/fedorov\u0022\u003E\u003Cstrong\u003EAndrei Fedorov\u003C\/strong\u003E\u003C\/a\u003E, Associate Chair for Graduate Studies, Rae S. and Frank H. Neely Chair, and professor in the George W. Woodruff School of Mechanical Engineering, has received two Research Project Grants (R01) from the National Institutes of Health (NIH).\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Andrei Fedorov, Associate Chair for Graduate Studies, Rae S. and Frank H. Neely Chair, and professor in the George W. Woodruff School of Mechanical Engineering, has received two Research Project Grants (R01) from the National Institutes of Health (NIH)."}],"uid":"36454","created_gmt":"2024-10-28 16:03:10","changed_gmt":"2024-10-28 16:04:13","author":"swilliamson40","boilerplate_text":"","field_publication":"","field_article_url":"","dateline":{"date":"2024-10-10T00:00:00-04:00","iso_date":"2024-10-10T00:00:00-04:00","tz":"America\/New_York"},"extras":[],"hg_media":{"675444":{"id":"675444","type":"image","title":"Andrei_FEdorov_22x3web.jpg","body":null,"created":"1730131399","gmt_created":"2024-10-28 16:03:19","changed":"1730131399","gmt_changed":"2024-10-28 16:03:19","alt":"Andrei Federov","file":{"fid":"259068","name":"Andrei_FEdorov_22x3web.jpg","image_path":"\/sites\/default\/files\/2024\/10\/28\/Andrei_FEdorov_22x3web.jpg","image_full_path":"http:\/\/hg.gatech.edu\/\/sites\/default\/files\/2024\/10\/28\/Andrei_FEdorov_22x3web.jpg","mime":"image\/jpeg","size":127964,"path_740":"http:\/\/hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/2024\/10\/28\/Andrei_FEdorov_22x3web.jpg?itok=LkQBAHfe"}}},"media_ids":["675444"],"related_links":[{"url":"https:\/\/me.gatech.edu\/news\/andrei-fedorov-and-collaborators-awarded-481-million-develop-new-instrumentation-biomedical","title":""}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[{"id":"138","name":"Biotechnology, Health, Bioengineering, Genetics"}],"keywords":[{"id":"187423","name":"go-bio"}],"core_research_areas":[{"id":"39441","name":"Bioengineering and Bioscience"}],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Cem\u003EBy Chloe Arrington\u003C\/em\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}