{"676889":{"#nid":"676889","#data":{"type":"event","title":"PhD Proposal by Ray Copeland","body":[{"value":"\u003Cp\u003EQuantitative Biosciences Thesis Proposal\u003Cbr\u003E\u003Cbr\u003E\u003Cstrong\u003ERay Copeland\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003ESchool of Physics\u003Cbr\u003EAdvisor: Dr. Peter Yunker (School of Physics)\u003Cbr\u003EOpen to the Community\u003Cbr\u003E\u003Cbr\u003E\u003Cstrong\u003EPhysical Simulations of Microbial Population Dynamics\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EFriday, September 27, 2024\u003C\/p\u003E\u003Cp\u003E11:00am\u003C\/p\u003E\u003Cp\u003EIn Person Location: Cherry Emerson, Room 204\u003Cbr\u003EZoom Link:\u0026nbsp;\u003Ca href=\u0022https:\/\/gatech.zoom.us\/j\/7615576281?omn=93425677064\u0022\u003Ehttps:\/\/gatech.zoom.us\/j\/7615576281?omn=93425677064\u003C\/a\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003ECommittee Members:\u003C\/p\u003E\u003Cp\u003EDr. William Ratcliff (School of Biological Sciences)\u003C\/p\u003E\u003Cp\u003EDr. JC Gumbart (School of Physics)\u003C\/p\u003E\u003Cp\u003EDr. Brian Hammer (School of Biological Sciences)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EAbstract:\u003C\/p\u003E\u003Cp\u003EBacterial communities play a crucial role in human health, ranging from pathogenic organisms that cause diseases to the gut microbiome that influences digestion and overall well-being. These microbial populations face various lethal pressures, including interspecies warfare and antibiotic exposure, which significantly shape their composition.\u003C\/p\u003E\u003Cp\u003E\u003Cbr\u003EMicrobial warfare can rapidly alter population dynamics, potentially eradicating entire genotypes within a few generations. The type VI secretion system has recently garnered significant attention as a mechanism for such warfare. However, literature reveals a diverse array of toxins with varying lethality rates. In our paper, \u0022Spatial constraints and stochastic seeding subvert microbial arms race,\u0022 we employ various physical simulation assumptions to demonstrate that spatial limitations and random seeding patterns diminish the effectiveness of contact-dependent killing processes. These findings suggest that realistic environmental conditions play a crucial role in shaping bacterial community composition.\u003C\/p\u003E\u003Cp\u003E\u003Cbr\u003EIn another study, I investigate how beta-lactamase enzyme efficiency influence population dynamics under antibiotic pressure. Using a mean-field model incorporating multiple bacterial strains, enzyme production, and antibiotic degradation, we reveal counterintuitive dynamics in antibiotic resistance evolution. Our findings demonstrate that increased enzyme efficacy doesn\u0027t always benefit resistant populations at the community level, and that diverse bacterial communities cannot always, but sometimes can, be accurately represented by average behaviors.\u003C\/p\u003E\u003Cp\u003E\u003Cbr\u003EMy future work will focus on how the antibiotic resistance dynamics above are altered in spatially structured settings, and how diffusive warfare impacts the spatial structure of microbial communities.\u003C\/p\u003E","summary":"","format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E\u003Cstrong\u003EPhysical Simulations of Microbial Population Dynamics\u003C\/strong\u003E\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Physical Simulations of Microbial Population Dynamics"}],"uid":"27707","created_gmt":"2024-09-17 16:39:21","changed_gmt":"2024-09-17 16:39:46","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2024-09-27T11:00:00-04:00","event_time_end":"2024-09-27T13:00:00-04:00","event_time_end_last":"2024-09-27T13:00:00-04:00","gmt_time_start":"2024-09-27 15:00:00","gmt_time_end":"2024-09-27 17:00:00","gmt_time_end_last":"2024-09-27 17:00:00","rrule":null,"timezone":"America\/New_York"},"location":"Cherry Emerson, Room 204","extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"102851","name":"Phd proposal"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78771","name":"Public"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}