{"676855":{"#nid":"676855","#data":{"type":"event","title":"Cherry Emerson Lecture - Prof. Shaomeng Wang (University of Michigan)","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003ETargeting Protein-Protein Interactions for New Cancer Therapies: From Inhibition to Degradation\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;Abstract:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EProtein-protein interactions (PPIs) represent a large class of under-explored therapeutic targets and targeting PPIs has traditionally been considered as \u201cundruggable\u201d. Our laboratory has been focusing on developing small-molecules to block PPIs as a novel therapeutic strategy for the development of new cancer medicines. Our efforts have led to advancement of 10 compounds currently in Phase 1-3 clinical development and several more in advanced preclinical development. In this lecture, I will share with you our journey in targeting PPIs, using both inhibition and degradation strategies. Our research has demonstrated that many PPIs are druggable targets and targeting PPIs represents a promising therapeutic strategy for cancer and other human diseases.\u0026nbsp;\u0026nbsp;\u0026nbsp;\u003C\/p\u003E","summary":"","format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EOne in the series of the SoCB seminars.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"School of Chemistry \u0026 Biochemistry -Seminar Series"}],"uid":"36441","created_gmt":"2024-09-17 13:03:43","changed_gmt":"2024-09-30 14:38:58","author":"slawrence67","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2024-10-10T15:30:00-04:00","event_time_end":"2024-10-10T16:30:00-04:00","event_time_end_last":"2024-10-10T16:30:00-04:00","gmt_time_start":"2024-10-10 19:30:00","gmt_time_end":"2024-10-10 20:30:00","gmt_time_end_last":"2024-10-10 20:30:00","rrule":null,"timezone":"America\/New_York"},"location":"MoSE - G011","extras":[],"groups":[{"id":"85951","name":"School of Chemistry and Biochemistry"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"177814","name":"Postdoc"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Cstrong\u003EHost\u003C\/strong\u003E: Valentino Perez\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}