{"675099":{"#nid":"675099","#data":{"type":"event","title":"BioE PhD Defense Presentation- Adriana Mulero-Russe","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EThesis Advisor\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EAndre\u0301s J. Garci\u0301a, Ph.D., George W. Woodruff School of Mechanical Engineering, Georgia Institute\u0026nbsp;of Technology\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EThesis Committee Members\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EMichael A. Helmrath, M.D.\u0026nbsp; Division of Pediatric Surgery, Cincinnati Children\u0027s Hospital Medical Center\u003C\/p\u003E\u003Cp\u003EHang Lu, Ph.D., School of Chemical and Biomolecular Engineering, Georgia Institute of Technology\u003C\/p\u003E\u003Cp\u003EAsma Nusrat, M.D., Department of Pathology, University of Michigan Medical Campus\u003C\/p\u003E\u003Cp\u003EJohnna S. Temenoff, Ph.D., Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EEngineered Synthetic Hydrogel Platform For Human Intestinal Organoids In Vitro Culture And In Vivo Therapeutic Delivery\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EHuman intestinal organoids (HIOs) represent an excellent in vitro model of the human intestine and a promising source for intestinal tissue repair therapies. Major limitations to the clinical translatability of the HIO technology are limited HIO \u003Cem\u003Ein vitro\u003C\/em\u003E\u0026nbsp;differentiation reproducibility and the lack of clinically relevant \u003Cem\u003Ein vivo\u003C\/em\u003E\u0026nbsp;delivery materials. This thesis project aims to address these challenges by engineering a 2D synthetic hydrogel to support the initial stages of the HIO\u003Cem\u003E\u0026nbsp;in vitro\u003C\/em\u003E\u0026nbsp;differentiation process and engineering a clinically translatable synthetic hydrogel vehicle to support \u003Cem\u003Ein vivo\u003C\/em\u003E\u0026nbsp;HIO cell engraftment to the injured intestinal tissue. The objectives of this thesis were accomplished in two aims. In Aim 1, I generated a 2D synthetic hydrogel substrate that can support human induced pluripotent stem cell attachment and support definitive endoderm differentiation. In Aim 2, I engineered a synthetic hydrogel to deliver human intestinal organoids to the injured intestine enabling their engraftment into the intestinal wall. The results of this thesis will provide a foundation for enhanced HIO therapeutic potential and clinically translatable materials to advance the use of HIO in the regenerative medicine field.\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EZoom link: \u003Ca href=\u0022https:\/\/gatech.zoom.us\/j\/99129280007?pwd=Y8Ry5GbusfacOw1xRcyMNfXXSrY8t1.1\u0022 target=\u0022_blank\u0022\u003Ehttps:\/\/gatech.zoom.us\/j\/99129280007?pwd=Y8Ry5GbusfacOw1xRcyMNfXXSrY8t1.1\u003C\/a\u003E\u003C\/p\u003E","summary":"","format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioE PhD Defense Presentation- \u0022Engineered Synthetic Hydrogel Platform For Human Intestinal Organoids In Vitro Culture And In Vivo Therapeutic Delivery\u0022- Adriana Mulero-Russe\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Engineered Synthetic Hydrogel Platform For Human Intestinal Organoids In Vitro Culture And In Vivo Therapeutic Delivery\u0022"}],"uid":"27917","created_gmt":"2024-06-13 13:06:57","changed_gmt":"2024-06-13 13:08:22","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2024-06-25T13:00:00-04:00","event_time_end":"2024-06-25T15:00:00-04:00","event_time_end_last":"2024-06-25T15:00:00-04:00","gmt_time_start":"2024-06-25 17:00:00","gmt_time_end":"2024-06-25 19:00:00","gmt_time_end_last":"2024-06-25 19:00:00","rrule":null,"timezone":"America\/New_York"},"location":"EBB CHOA room","extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"172056","name":"go-BioE"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}