{"674698":{"#nid":"674698","#data":{"type":"event","title":"PhD Proposal by Ishita Kumar","body":[{"value":"\u003Cp\u003EIshita Kumar\u003C\/p\u003E\r\n\r\n\u003Cp\u003EBioE Ph.D. Proposal Presentation\u003C\/p\u003E\r\n\r\n\u003Cp\u003EMay 23, 2024\u003C\/p\u003E\r\n\r\n\u003Cp\u003E11:30 AM\u003C\/p\u003E\r\n\r\n\u003Cp\u003ELocation: Krone Engineered Biosystems Building (EBB) 2029 Conference Room\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Ca href=\u0022https:\/\/gatech.zoom.us\/j\/4949153825?pwd=T2drbHUzYmc3UnZsVXBVVFUvY2dMdz09\u0026amp;omn=91937286555\u0022\u003Ehttps:\/\/gatech.zoom.us\/j\/4949153825?pwd=T2drbHUzYmc3UnZsVXBVVFUvY2dMdz09\u0026amp;omn=91937286555\u003C\/a\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EMeeting ID:\u0026nbsp;494 915 3825\u003C\/p\u003E\r\n\r\n\u003Cp\u003EPasscode: 110913\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAdvisor\u003C\/strong\u003E: Corey J. Wilson, Ph.D. (School of Chemical and Biomolecular Engineering, Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee\u003C\/strong\u003E:\u003C\/p\u003E\r\n\r\n\u003Cp\u003EJohn Blazeck, Ph.D. (School of Chemical and Biomolecular Engineering, Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EHang Lu, Ph.D. (School of Chemical and Biomolecular Engineering, Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003ERavi Kane, Ph.D. (School of Chemical and Biomolecular Engineering, Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003ERichard M. Murray, Ph.D. (Division of Biology and Biological Engineering, California Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ENext-Generation Biosecurity: Advancing Tools for Multi-Layer Security\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EThe rapid expansion of synthetic biology from laboratory spaces to industrial and healthcare sectors has brought about concerns of unwanted release of genetically modified organisms and protection of biological intellectual property. Current physical and operational security measures for these assets can be comprised by theft or accidental release. This thesis proposes the designing, building, and testing of a next-generation biosecurity system that is intrinsic to the engineered organism. While prior studies have demonstrated basic intrinsic security measures, there is considerable value in advancing the state of the art with novel tools, multi-layer security platforms, and the introduction of penetration testing. First, an 8-digit biological keypad will be developed in \u003Cem\u003EEscherichia coli\u003C\/em\u003E\u0026nbsp;for 2-input and 3-input passcodes to protect a biological asset. This technology will be combined with toxin-based penalties to design a first-of-its-kind Biohackathon challenge. Furthermore, a novel \u2018Command Center\u2019 for editing biological programs will be shown in situ using an engineered \u003Cem\u003EE. coli \u003C\/em\u003Estrain. The Command Center would be a promising tool for biosecurity applications. Finally, an authentication system will be engineered through synthetic auxotrophy, and will be deployed with other biosecurity measures to a design a second Biohackathon challenge. Together, these technologies will establish a foundation for integrating multi-layer biosecurity into biotechnology.\u003C\/p\u003E\r\n","summary":"","format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E\u003Cstrong\u003ENext-Generation Biosecurity: Advancing Tools for Multi-Layer Security\u003C\/strong\u003E\u003C\/p\u003E\r\n","format":"limited_html"}],"field_summary_sentence":[{"value":"Next-Generation Biosecurity: Advancing Tools for Multi-Layer Security"}],"uid":"27707","created_gmt":"2024-05-13 17:18:20","changed_gmt":"2024-05-13 17:18:52","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2024-05-23T11:30:00-04:00","event_time_end":"2024-05-23T13:00:00-04:00","event_time_end_last":"2024-05-23T13:00:00-04:00","gmt_time_start":"2024-05-23 15:30:00","gmt_time_end":"2024-05-23 17:00:00","gmt_time_end_last":"2024-05-23 17:00:00","rrule":null,"timezone":"America\/New_York"},"location":" Krone Engineered Biosystems Building (EBB) 2029 Conference Room","extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"102851","name":"Phd proposal"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78771","name":"Public"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}