{"674494":{"#nid":"674494","#data":{"type":"news","title":"Cellular Study Uncovers \u0027Whole-Body\u0027 Impacts of Endurance Exercise","body":[{"value":"\u003Cp\u003EIn a \u003Ca href=\u0022https:\/\/www.nature.com\/articles\/s41586-023-06877-w\u0022\u003Egroup of papers\u003C\/a\u003E released May 1 in the journal \u003Cem\u003ENature,\u003C\/em\u003E scientists \u003Ca href=\u0022https:\/\/www.nature.com\/articles\/d41586-024-01200-7\u0022\u003Eare one step closer\u003C\/a\u003E to a whole-body map of the body\u2019s cellular responses to endurance exercise \u2014 identifying striking \u003Ca href=\u0022https:\/\/www.nih.gov\/news-events\/news-releases\/endurance-exercise-affects-all-tissues-body-even-those-not-normally-associated-movement\u0022\u003E\u201call tissue effects\u201d of training\u003C\/a\u003E, even in tissues from organs not normally associated with movement.\u003C\/p\u003E\r\n\r\n\u003Cp\u003EThe findings are the latest product of the \u003Ca href=\u0022https:\/\/www.motrpac.org\/\u0022\u003E\u003Cstrong\u003EMolecular Transducers of Physical Activity Consortium (MoTrPAC)\u003C\/strong\u003E\u003C\/a\u003E, a ten-year effort launched in 2016 by the National Institutes of Health (NIH) to uncover how exercise improves and maintains our health at the molecular level.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Ca href=\u0022https:\/\/research.gatech.edu\/\u0022\u003EGeorgia Institute of Technology\u003C\/a\u003E bioanalytical chemist \u003Cstrong\u003EFacundo Fern\u00e1ndez\u003C\/strong\u003E and \u003Ca href=\u0022https:\/\/www.emory.edu\/home\/research\/index.html\u0022\u003EEmory University\u003C\/a\u003E biochemist \u003Cstrong\u003EEric Ortlund\u003C\/strong\u003E lead one of the \u003Ca href=\u0022https:\/\/news.emory.edu\/stories\/2020\/06\/emory_georgia_tech_exercise_study\/index.html\u0022\u003EConsortium\u2019s Chemical Analysis Sites\u003C\/a\u003E, joining researchers across the country to collect and translate data from animals and more than 2,000 volunteers into comprehensive maps of the cellular changes throughout the body in response to exercise.\u003C\/p\u003E\r\n\r\n\u003Cp\u003EThe $226 million MoTrPAC NIH Common Fund investment also hopes to help people with chronic illnesses identify specific physical activities to improve individual health, and to potentially unearth therapeutic targets \u2014 medicines that might mimic the positive effects of exercise.\u003C\/p\u003E\r\n\r\n\u003Cp\u003EMoTrPAC\u2019s latest group of papers details data from studies in rats, \u003Ca href=\u0022https:\/\/www.nih.gov\/news-events\/news-releases\/endurance-exercise-affects-all-tissues-body-even-those-not-normally-associated-movement\u0022\u003Euncovering how endurance exercise\u003C\/a\u003E affects biological molecules and \u201call tissues of the body,\u201d as well as tissues and gene expression, along with striking tissue differences between male and female organisms.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ERead more: \u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cul\u003E\r\n\t\u003Cli\u003E\u003Cstrong\u003ENature\u003C\/strong\u003E | \u003Ca href=\u0022https:\/\/www.nature.com\/articles\/d41586-024-01200-7\u0022\u003EWhy is exercise good for you? Scientists are finding answers in our cells\u003C\/a\u003E\u003C\/li\u003E\r\n\t\u003Cli\u003E\u003Cstrong\u003ENIH\u003C\/strong\u003E | \u003Ca href=\u0022https:\/\/www.nih.gov\/news-events\/news-releases\/endurance-exercise-affects-all-tissues-body-even-those-not-normally-associated-movement\u0022\u003EEndurance exercise affects all tissues of the body, even those not normally associated with movement\u003C\/a\u003E\u003C\/li\u003E\r\n\t\u003Cli\u003E\u003Cstrong\u003EDOI\u003C\/strong\u003E | \u003Ca href=\u0022https:\/\/www.nature.com\/articles\/s41586-023-06877-w\u0022\u003E\u201cTemporal dynamics of the multi-omic response to endurance exercise training\u201d\u003C\/a\u003E\u003C\/li\u003E\r\n\u003C\/ul\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u003Cem\u003EFacundo M. Fernandez\u003C\/em\u003E\u003C\/strong\u003E\u003Cem\u003E, is Regents\u2019 Professor and Vasser Woolley Foundation Chair in Bioanalytical Chemistry at Georgia Tech. He also serves as associate editor of the Journal of the American Society for Mass Spectrometry (JASMS).\u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u003Cem\u003EEric Ortlund\u003C\/em\u003E\u003C\/strong\u003E\u003Cem\u003E is a professor in the Department of Biochemistry at Emory University and a member of the Discovery and Developmental Therapeutics Research Program at Winship Cancer Institute.\u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u003Cem\u003EStudy co-authors from Georgia Tech\u003C\/em\u003E\u003C\/strong\u003E\u003Cem\u003E also include \u003Cstrong\u003EDavid A. Gaul\u003C\/strong\u003E (School of Chemistry and Biochemistry, along with \u003Cstrong\u003ESamuel G. Moore \u003C\/strong\u003E(Petit Institute of Bioengineering and Biosciences). \u003Cstrong\u003EEmory University co-authors \u003C\/strong\u003Ealso include \u003Cstrong\u003ETiantian Zhang\u003C\/strong\u003E and \u003Cstrong\u003EZhenxin Hou \u003C\/strong\u003E(Department of Biochemistry).\u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EFunding: \u003C\/strong\u003EThe MoTrPAC Study is supported by \u003Ca href=\u0022https:\/\/www.nature.com\/articles\/s41586-023-06877-w\u0022\u003Emultiple NIH grants and institutes\u003C\/a\u003E, as well as the National Science Foundation (NSF), the Knut and Alice Wallenberg Foundation, and NORC at the University of Chicago.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cem\u003ENIH grants include: U24OD026629 (Bioinformatics Center), U24DK112349, U24DK112342, U24DK112340, U24DK112341, U24DK112326, U24DK112331, U24DK112348 (Chemical Analysis Sites), U01AR071133, U01AR071130, U01AR071124, U01AR071128, U01AR071150, U01AR071160, U01AR071158 (Clinical Centers), U24AR071113 (Consortium Coordinating Center), U01AG055133, U01AG055137 and U01AG055135 (PASS\/Animal Sites); as well as NHGRI Institutional Training Grant in Genome Science 5T32HG000044; National Heart, Lung, and Blood Institute of the National Institute of Health F32 postdoctoral fellowship award F32HL154711; National Institute on Aging P30AG044271 and P30AG003319.\u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n","summary":"","format":"limited_html"}],"field_subtitle":[{"value":"MoTrPAC scientists are creating a whole-body map of molecular responses to endurance training \u2014 finding striking \u201call tissue effects\u201d in a new set of studies"}],"field_summary":[{"value":"\u003Cp\u003EExercise is good for you. To understand why, MoTrPAC scientists are creating a whole-body map of molecular responses to endurance training \u2014 finding striking \u201call tissue effects\u201d in a new set of studies, featured on this month\u2019s cover of the journal \u003Cem\u003ENature\u003C\/em\u003E.\u003C\/p\u003E\r\n","format":"limited_html"}],"field_summary_sentence":[{"value":"Exercise is good for you. To understand why, MoTrPAC scientists are creating a whole-body map of molecular responses to endurance training \u2014 finding striking \u201call tissue effects\u201d in a new set of studies, featured on the May cover of the journal Nature."}],"uid":"34528","created_gmt":"2024-05-02 20:40:54","changed_gmt":"2024-05-02 20:44:59","author":"jhunt7","boilerplate_text":"","field_publication":"","field_article_url":"","dateline":{"date":"2024-05-02T00:00:00-04:00","iso_date":"2024-05-02T00:00:00-04:00","tz":"America\/New_York"},"extras":[],"hg_media":{"673933":{"id":"673933","type":"image","title":"The May 2024 cover of the journal Nature, featuring MoTrPAC findings.","body":null,"created":"1714682479","gmt_created":"2024-05-02 20:41:19","changed":"1714682479","gmt_changed":"2024-05-02 20:41:19","alt":"The May 2024 cover of the journal Nature, featuring MoTrPAC findings.","file":{"fid":"257390","name":"naturecover-motrpac.jpg","image_path":"\/sites\/default\/files\/2024\/05\/02\/naturecover-motrpac.jpg","image_full_path":"http:\/\/hg.gatech.edu\/\/sites\/default\/files\/2024\/05\/02\/naturecover-motrpac.jpg","mime":"image\/jpeg","size":247686,"path_740":"http:\/\/hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/2024\/05\/02\/naturecover-motrpac.jpg?itok=mymjzQ9a"}},"636490":{"id":"636490","type":"image","title":"Facundo M. Fernandez and Eric Ortlund ","body":null,"created":"1593099266","gmt_created":"2020-06-25 15:34:26","changed":"1714682596","gmt_changed":"2024-05-02 20:43:16","alt":"Facundo M. Fernandez and Eric Ortlund ","file":{"fid":"242165","name":"Fernandez and Ortlund.jpg","image_path":"\/sites\/default\/files\/images\/Fernandez%20and%20Ortlund.jpg","image_full_path":"http:\/\/hg.gatech.edu\/\/sites\/default\/files\/images\/Fernandez%20and%20Ortlund.jpg","mime":"image\/jpeg","size":2379860,"path_740":"http:\/\/hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/Fernandez%20and%20Ortlund.jpg?itok=emr7a46k"}}},"media_ids":["673933","636490"],"related_links":[{"url":"https:\/\/cos.gatech.edu\/news\/emory-georgia-tech-participating-six-year-exercise-research-study","title":"Emory, Georgia Tech Participating in MoTrPAC Exercise Research Study"}],"groups":[{"id":"1278","name":"College of Sciences"},{"id":"1188","name":"Research Horizons"},{"id":"85951","name":"School of Chemistry and Biochemistry"}],"categories":[{"id":"138","name":"Biotechnology, Health, Bioengineering, Genetics"},{"id":"141","name":"Chemistry and Chemical Engineering"},{"id":"146","name":"Life Sciences and Biology"}],"keywords":[{"id":"193266","name":"cos-research"},{"id":"192258","name":"cos-data"},{"id":"187915","name":"go-researchnews"},{"id":"187423","name":"go-bio"}],"core_research_areas":[{"id":"39441","name":"Bioengineering and Bioscience"},{"id":"39501","name":"People and Technology"}],"news_room_topics":[{"id":"71891","name":"Health and Medicine"}],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EPress Contacts:\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Ca href=\u0022mailto:jess@cos.gatech.edu\u0022\u003E\u003Cstrong\u003EJess Hunt-Ralston\u003C\/strong\u003E\u003C\/a\u003E\u003Cbr \/\u003E\r\nDirector of Communications\u003Cbr \/\u003E\r\nCollege of Sciences\u003Cbr \/\u003E\r\nGeorgia Tech\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Ca href=\u0022mailto:anthony.van.witsen@emory.edu\u0022\u003E\u003Cstrong\u003EAnthony (Tony) Van Witsen\u003C\/strong\u003E\u003C\/a\u003E\u003Cstrong\u003E \u003C\/strong\u003E\u003Cbr \/\u003E\r\nHealth Sciences Writer\u003Cbr \/\u003E\r\nWoodruff Health Sciences Center\u003Cbr \/\u003E\r\nEmory University\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Ca href=\u0022mailto:andrea.harris@nih.gov\u0022\u003E\u003Cstrong\u003EAndr\u00e9a Harris\u003C\/strong\u003E\u003C\/a\u003E, Ph.D., M.S.P.H., S.C.P.M.\u003Cbr \/\u003E\r\nHealth Science Policy Analyst\u003Cbr \/\u003E\r\nOffice of Strategic Coordination \u2013 The Common Fund\u003Cbr \/\u003E\r\nDivision of Program Coordination, Planning, and Strategic Initiatives\u003Cbr \/\u003E\r\nOffice of the Director, NIH\u003C\/p\u003E\r\n","format":"limited_html"}],"email":["jess@cos.gatech.edu"],"slides":[],"orientation":[],"userdata":""}}}