{"674335":{"#nid":"674335","#data":{"type":"news","title":"New Electron Videography Technique Captures Dance Between Proteins and Lipids","body":[{"value":"\u003Cp\u003E\u003Cem\u003EThis article was first published in the University of Illinois Urbana-Champaign newsroom. Read the full story \u003C\/em\u003E\u003Ca href=\u0022https:\/\/news.illinois.edu\/view\/6367\/34729291\u0022\u003E\u003Cem\u003Ehere\u003C\/em\u003E\u003C\/a\u003E\u003Cem\u003E.\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003EResearchers at Georgia Institute of Technology and the University of Illinois Urbana-Champaign have developed a first-of-its-kind technique called electron videography to capture moving images at the molecular scale. In the first demonstration of the technique, the team took a microscopic moving picture of the delicate dance between proteins and lipids found in cell membranes. The study, \u201c\u003Ca href=\u0022https:\/\/www.science.org\/doi\/10.1126\/sciadv.adk0217\u0022\u003EElectron videography of a lipid\u2013protein tango\u003C\/a\u003E\u201d was published last week in the journal \u003Cem\u003EScience Advances\u003C\/em\u003E.\u003C\/p\u003E\u003Cp\u003E\u0022This is the first time we are looking at a protein on an individual scale and haven\u0027t frozen it or tagged it,\u0022 says \u003Cstrong\u003EAditi Das\u003C\/strong\u003E, a corresponding author and associate professor in the \u003Ca href=\u0022https:\/\/chemistry.gatech.edu\/people\/aditi-das\u0022\u003ESchool of Chemistry and Biochemistry\u003C\/a\u003E at Georgia Tech.\u003C\/p\u003E\u003Cp\u003EElectron microscopy techniques image at the molecular or atomic scale, yielding detailed, nanometer-scale pictures. However, they often rely on samples that have been frozen or fixed in place, leaving scientists to try to infer how molecules move and interact \u2014 like trying to map the choreography of a dance sequence from a single frame of film.\u003C\/p\u003E\u003Cp\u003E\u0022Usually, we have to crystalize or freeze a protein, which poses challenges in capturing high-resolution images of flexible proteins. Alternately, some techniques use a molecular tag that we track, rather than watching the protein itself,\u201d Das says. \u201cIn this study we are seeing the protein as it is, behaving how it does in a liquid environment, and seeing how lipids and proteins interact with each other.\u0022\u003C\/p\u003E\u003Cp\u003EThe technique can be used to study the dynamics of other biomolecules, breaking free of constraints that have limited microscopy to still images of fixed molecules. In this study, the team examined nanoscale discs of lipid membranes and how they interacted with proteins normally found on the surface of or embedded in cell membranes.\u003C\/p\u003E\u003Cp\u003EThese membrane proteins are significant for medical treatments, and are involved in processes including muscle contraction, brain function, and immune system functions. Moving forward, the researchers plan to use their electron videography technique to study other types of membrane proteins and other classes of molecules and nanomaterials.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EDOI: \u003Ca href=\u0022https:\/\/www.science.org\/doi\/10.1126\/sciadv.adk0217\u0022\u003E10.1126\/sciadv.adk0217\u003C\/a\u003E\u003C\/p\u003E","summary":"","format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe new technique can be used to study the dynamics of other biomolecules, breaking free of constraints that have limited microscopy to still images of fixed molecules. \u201cThis is the first time we are looking at a protein on an individual scale and haven\u0027t frozen it or tagged it,\u201d says Aditi Das, associate professor in the School of Chemistry and Biochemistry.\u003C\/p\u003E\r\n","format":"limited_html"}],"field_summary_sentence":[{"value":"The new technique can be used to study the dynamics of other biomolecules, breaking free of constraints that have limited microscopy to still images of fixed molecules."}],"uid":"35599","created_gmt":"2024-04-23 14:51:02","changed_gmt":"2024-09-10 16:33:53","author":"sperrin6","boilerplate_text":"","field_publication":"","field_article_url":"","dateline":{"date":"2024-04-23T00:00:00-04:00","iso_date":"2024-04-23T00:00:00-04:00","tz":"America\/New_York"},"extras":[],"hg_media":{"673811":{"id":"673811","type":"image","title":"Aditi Das","body":null,"created":"1713884130","gmt_created":"2024-04-23 14:55:30","changed":"1713884130","gmt_changed":"2024-04-23 14:55:30","alt":"Aditi Das","file":{"fid":"257253","name":"AditiDas.jpeg","image_path":"\/sites\/default\/files\/2024\/04\/23\/AditiDas.jpeg","image_full_path":"http:\/\/hg.gatech.edu\/\/sites\/default\/files\/2024\/04\/23\/AditiDas.jpeg","mime":"image\/jpeg","size":554462,"path_740":"http:\/\/hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/2024\/04\/23\/AditiDas.jpeg?itok=LGtwlGGH"}},"673812":{"id":"673812","type":"image","title":"A computational model, based on raw video from electron videography, showing the motion of a nanodisc composed of lipids (red) and a membrane protein (green) in water.  GIF courtesy of John W. Smith","body":"\u003Cp\u003EA computational model, based on raw video from electron videography, showing the motion of a nanodisc composed of lipids (red) and a membrane protein (green) in water.\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGIF courtesy of John W. Smith\u003C\/p\u003E\r\n","created":"1713884130","gmt_created":"2024-04-23 14:55:30","changed":"1713884130","gmt_changed":"2024-04-23 14:55:30","alt":"A computational model, based on raw video from electron videography, showing the motion of a nanodisc composed of lipids (red) and a membrane protein (green) in water.  GIF courtesy of John W. Smith","file":{"fid":"257254","name":"GIF.gif","image_path":"\/sites\/default\/files\/2024\/04\/23\/GIF.gif","image_full_path":"http:\/\/hg.gatech.edu\/\/sites\/default\/files\/2024\/04\/23\/GIF.gif","mime":"image\/gif","size":3019331,"path_740":"http:\/\/hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/2024\/04\/23\/GIF.gif?itok=0cAudx4c"}}},"media_ids":["673811","673812"],"groups":[{"id":"1278","name":"College of Sciences"},{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[{"id":"135","name":"Research"}],"keywords":[{"id":"193659","name":"go-microbial"},{"id":"193266","name":"cos-research"},{"id":"192250","name":"cos-microbial"},{"id":"187423","name":"go-bio"},{"id":"187915","name":"go-researchnews"}],"core_research_areas":[{"id":"39441","name":"Bioengineering and Bioscience"}],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EContact:\u003Cbr\u003E\u003Ca href=\u0022mailto: jess.hunt@cos.gatech.edu\u0022\u003EJess-Hunt Ralston\u003C\/a\u003E\u003Cbr\u003EDirector of Communications\u003Cbr\u003ECollege of Sciences\u003Cbr\u003EGeorgia Tech\u003C\/p\u003E","format":"limited_html"}],"email":["jess@cos.gatech.edu"],"slides":[],"orientation":[],"userdata":""}}}