{"673759":{"#nid":"673759","#data":{"type":"news","title":"Two-Way Cell-based Treatment Repairs Muscle After Rotator Cuff Injury","body":[{"value":"\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003EA team of Georgia Tech researchers has introduced a \u003C\/span\u003E\u003Ca href=\u0022https:\/\/pubmed.ncbi.nlm.nih.gov\/37897061\/\u0022\u003E\u003Cspan\u003Enew therapeutic system\u003C\/span\u003E\u003C\/a\u003E\u003Cspan\u003E to offset the poor clinical outcomes often associated with common rotator cuff surgery. \u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003EIt\u2019s the kind of surgery that makes headlines whenever a famous athlete is sidelined with a torn rotator cuff. Major League Baseball All-Star pitchers Clayton Kershaw and Justin Verlander, for example, both had rotator cuff surgeries and made successful comebacks.\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003EFor those of us who can\u2019t throw baseballs 95 miles an hour, the rotator cuff may tear over time from repeated overhead motions (painters and carpenters, for instance). Or an injury can occur as we age and our body\u2019s tissues naturally degenerate. And although rotator cuff injuries are common, they can be serious, leading to muscle degeneration after surgery. \u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003ENow, two professors from the \u003C\/span\u003E\u003Ca href=\u0022https:\/\/bme.gatech.edu\/bme\/\u0022\u003E\u003Cspan\u003EWallace H. Coulter Department of Biomedical Engineering\u003C\/span\u003E\u003C\/a\u003E\u003Cspan\u003E, a joint department of Georgia Tech and Emory University, have addressed the problem with a novel cell-based dual treatment, which they describe in a study published recently in the journal \u003C\/span\u003E\u003Ca href=\u0022https:\/\/home.liebertpub.com\/publications\/tissue-engineering-parts-a-b-and-c\/595\/overview\u0022\u003E\u003Cem\u003E\u003Cspan\u003ETissue Engineering\u003C\/span\u003E\u003C\/em\u003E\u003C\/a\u003E\u003Cspan\u003E. \u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u201cWe\u2019re thinking mainly of an aging population with this study \u2014 the people most likely to have these injuries,\u201d said \u003C\/span\u003E\u003Ca href=\u0022https:\/\/bme.gatech.edu\/bme\/faculty\/Johnna-S.-Temenoff\u0022\u003E\u003Cspan\u003EJohnna Temenoff\u003C\/span\u003E\u003C\/a\u003E\u003Cspan\u003E, whose research group collaborated with the lab of \u003C\/span\u003E\u003Ca href=\u0022https:\/\/bme.gatech.edu\/bme\/faculty\/Edward-Botchwey\u0022\u003E\u003Cspan\u003EEd Botchwey\u003C\/span\u003E\u003C\/a\u003E\u003Cspan\u003E on this work. \u201cThe great thing about this system is, it isn\u2019t specific to a particular population. These are cells we all have, and this treatment system might work even better in younger patients.\u201d\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Ch4\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cstrong\u003E\u003Cspan\u003ELocal Delivery\u003C\/span\u003E\u003C\/strong\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/h4\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003EThe rotator cuff is a group of muscles and tendons surrounding and protecting the shoulder joint, keeping the head of the upper arm bone firmly in the shallow socket of the shoulder. It\u2019s tight jumble of tissues, and not an easy environment for muscle regeneration.\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u201cWith a rotator cuff injury, you\u2019re actually tearing the tendon,\u201d said Temenoff, director of the NSF Engineering Research Center for Cell Manufacturing Technologies (\u003C\/span\u003E\u003Ca href=\u0022https:\/\/cellmanufacturingusa.org\/\u0022\u003E\u003Cspan\u003ECMaT\u003C\/span\u003E\u003C\/a\u003E\u003Cspan\u003E) at Georgia Tech. \u201cAnd that causes the muscle to atrophy.\u201d\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u0026nbsp;While pro athletes have access to world-class training and rehabilitation to help rebuild the shoulder following surgery, for many patients that rotator cuff muscle doesn\u2019t fully regenerate, even after a successful surgery. Temenoff isn\u2019t sure why. \u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u201cThat\u2019s a big unknown,\u201d she said. \u201cAnd it\u2019s a big field of study right now, an active area of research. There is a need for regenerative therapies that can be used in conjunction with rotator cuff restoration surgery, as a long-term treatment option \u2014that is what we are addressing.\u201d\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003EIn previous studies using mouse models, Temenoff found that she could change the cellular environment in the muscle with the local injection of microparticles loaded with a protein called stromal cell-derived factor (SDF), which can attract various pre-regenerative cells circulating to the muscle.\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Ch4\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cstrong\u003E\u003Cspan\u003EThe Push-Pull Effect\u003C\/span\u003E\u003C\/strong\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/h4\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003EThe idea is to mobilize the cells that can heal, the cells that rebuild muscle at the source. Getting enough of them to do the work is the trick. \u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Ca href=\u0022https:\/\/temenoff.gatech.edu\/\u0022\u003E\u003Cspan\u003ETemenoff\u2019s lab\u003C\/span\u003E\u003C\/a\u003E\u003Cspan\u003E has developed microparticles that use heparin, a natural sugar-based molecule found in the body that has a high negative charge. SDF is positive-charged, so that electrostatic interaction between the two particles allows for controlled release of SDF over time.\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003ESDF interacts almost magnetically with a receptor on pro-regenerative cells in bone marrow or circulation to \u201ccall\u201d them to a certain location. However, older people may not have enough of these cells in circulation to make much of a difference in healing. That\u2019s where \u003C\/span\u003E\u003Ca href=\u0022https:\/\/botchweylab.super.site\/\u0022\u003E\u003Cspan\u003EBotchwey\u2019s lab\u003C\/span\u003E\u003C\/a\u003E\u003Cspan\u003E entered with the major assist. \u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003EHis team provided experience with a bone marrow mobilizing agent (called VPC01091) that can send healing cells into circulation around the body. In clinical settings, bone marrow mobilizing agents are used to \u201cpush\u201d stem cells out of the marrow and into the blood. These cells can regenerate and differentiate into all kinds of cells in multiple tissue environments. \u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003EThe researchers set out to develop a single therapeutic option by combining the two technologies. Here\u0027s what happened when they tested the system in rats: The mobilizing agent was injected systemically while the SDF was injected locally into the shoulder. So, while the mobilizing agent \u201cpushed\u201d pro-healing cells into circulation, SDF\u2019s magnetic effect \u201cpulled\u201d them to the injury site, resulting in the desired regenerative effects.\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003EThe researchers found different levels of regeneration spatially\u2014in other words, where they applied the local injection really matters. Further research will aim to fine-tune the process, so clinicians can recruit healing cells to even more specific areas of the damaged muscle. Temenoff and her collaborators believe they are onto something that will result in better muscle regeneration, with potential applications beyond the rotator cuff.\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cem\u003E\u003Cspan\u003EThis work was supported by the National Institutes of Health (grant no. R01AR071026).\u003C\/span\u003E\u003C\/em\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cstrong\u003E\u003Cspan\u003ECITATION:\u003C\/span\u003E\u003C\/strong\u003E\u003Cspan\u003E Leah Anderson, Liane Tellier, Keshav Shah, Joseph Pearson, Alexandra Brimeyer, Ed Botchwey, Johnna Temenoff. \u201cBone Marrow Mobilization and Local Stromal Cell-Derived Factor-1a Delivery Enhances Nascent Supraspinatus Muscle Fiber Growth,\u201d \u003Cem\u003ETissue Engineering\u003C\/em\u003E. \u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cstrong\u003E\u003Cspan\u003EDOI: \u003C\/span\u003E\u003C\/strong\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1089\/ten.tea.2023.0128\u0022\u003E\u003Cstrong\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003Ehttps:\/\/doi.org\/10.1089\/ten.tea.2023.0128\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/strong\u003E\u003C\/a\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n","summary":"","format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003ENew treatment developed by BME researchers Johnna Temenoff and Ed Botchwey rallies regenerative cells to heal damaged muscle following rotator cuff injury and surgery.\u003C\/p\u003E\r\n","format":"limited_html"}],"field_summary_sentence":[{"value":"New treatment helps muscle regenerate following shoulder surgery"}],"uid":"28153","created_gmt":"2024-03-26 17:48:23","changed_gmt":"2024-03-26 17:56:19","author":"Jerry Grillo","boilerplate_text":"","field_publication":"","field_article_url":"","dateline":{"date":"2024-03-26T00:00:00-04:00","iso_date":"2024-03-26T00:00:00-04:00","tz":"America\/New_York"},"extras":[],"hg_media":{"673491":{"id":"673491","type":"image","title":"Rotator Cuff injury repair","body":"\u003Cp\u003EA combination of mobilizing agent, designed to \u201cpush\u201d pro-healing cells into the blood, and SDF-1a, designed to \u201cpull\u201d the cells into the injury site, leads to an increase in muscle regeneration following a rotator cuff tear. Muscle regeneration was characterized based on the number of centrally located nuclei (marked with the white arrows).\u003C\/p\u003E\r\n","created":"1711473853","gmt_created":"2024-03-26 17:24:13","changed":"1711473989","gmt_changed":"2024-03-26 17:26:29","alt":"Rotator cuff treatment","file":{"fid":"256890","name":"Rotator cuff image.png","image_path":"\/sites\/default\/files\/2024\/03\/26\/Rotator%20cuff%20image.png","image_full_path":"http:\/\/hg.gatech.edu\/\/sites\/default\/files\/2024\/03\/26\/Rotator%20cuff%20image.png","mime":"image\/png","size":2068638,"path_740":"http:\/\/hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/2024\/03\/26\/Rotator%20cuff%20image.png?itok=QGQe3y9J"}},"673492":{"id":"673492","type":"image","title":"Temenoff and Botchwey","body":"\u003Cp\u003ECoulter BME researchers Johnna Temenoff and Ed Botchwey\u003C\/p\u003E\r\n","created":"1711474201","gmt_created":"2024-03-26 17:30:01","changed":"1711474261","gmt_changed":"2024-03-26 17:31:01","alt":"Temenoff and Botchwey","file":{"fid":"256891","name":"Temenoff and Botchwey.jpg","image_path":"\/sites\/default\/files\/2024\/03\/26\/Temenoff%20and%20Botchwey.jpg","image_full_path":"http:\/\/hg.gatech.edu\/\/sites\/default\/files\/2024\/03\/26\/Temenoff%20and%20Botchwey.jpg","mime":"image\/jpeg","size":221678,"path_740":"http:\/\/hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/2024\/03\/26\/Temenoff%20and%20Botchwey.jpg?itok=Jw92Aaxm"}}},"media_ids":["673491","673492"],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"},{"id":"1188","name":"Research Horizons"},{"id":"1254","name":"Wallace H. Coulter Dept. of Biomedical Engineering"}],"categories":[{"id":"138","name":"Biotechnology, Health, Bioengineering, Genetics"},{"id":"145","name":"Engineering"},{"id":"146","name":"Life Sciences and Biology"},{"id":"135","name":"Research"}],"keywords":[{"id":"187423","name":"go-bio"},{"id":"187915","name":"go-researchnews"},{"id":"9534","name":"cell therapy"},{"id":"1489","name":"Regenerative Medicine"},{"id":"176933","name":"go-cmat"},{"id":"175498","name":"CMaT"},{"id":"80831","name":"rotator cuff"}],"core_research_areas":[{"id":"39441","name":"Bioengineering and Bioscience"}],"news_room_topics":[{"id":"71891","name":"Health and Medicine"},{"id":"71881","name":"Science and Technology"}],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:jerry.grillo@ibb.gatech.edu\u0022\u003EJerry Grillo\u003C\/a\u003E\u003C\/p\u003E\r\n","format":"limited_html"}],"email":["jerry.grillo@ibb.gatech.edu"],"slides":[],"orientation":[],"userdata":""}}}