{"669757":{"#nid":"669757","#data":{"type":"news","title":"Researchers Identify Crucial Biomarker That Tracks Recovery from Treatment-Resistant Depression","body":[{"value":"\u003Cp\u003EA team of clinicians, engineers, and neuroscientists has made a groundbreaking discovery in the field of treatment-resistant depression. By analyzing the brain activity of patients undergoing deep brain stimulation (DBS), the researchers identified a unique pattern in brain activity that reflects the recovery process in patients with treatment-resistant depression. This pattern, known as a biomarker, serves as a measurable indicator of disease recovery and represents a significant advance in treatment for \u003Ca href=\u0022https:\/\/www.emoryhealthcare.org\/centers-programs\/treatment-resistant-depression-program\/index.html\u0022\u003Ethe most severe and untreatable forms of depression\u003C\/a\u003E.\u003C\/p\u003E\r\n\r\n\u003Cp\u003EThe team\u2019s findings, \u003Ca href=\u0022https:\/\/www.nature.com\/articles\/s41586-023-06541-3\u0022\u003Epublished in the journal \u003Cem\u003ENature\u003C\/em\u003E Sept. 20\u003C\/a\u003E, offer the first window into the intricate workings and mechanistic effects of DBS on the brain during treatment for severe depression.\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDBS involves implanting thin electrodes in a specific brain area to deliver small electrical pulses, similar to a pacemaker. Although DBS has been approved and used for movement disorders such as Parkinson\u2019s disease for many years, it remains experimental for depression.\u003C\/p\u003E\r\n\r\n\u003Cp\u003EThis study is a crucial step toward using objective data collected directly from the brain via the DBS device to inform clinicians about the patient\u2019s response to treatment. This information can help guide adjustments to DBS therapy, tailoring it to each patient\u2019s unique response and optimizing their treatment outcomes.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Ca href=\u0022https:\/\/coe.gatech.edu\/news\/2023\/09\/researchers-identify-crucial-biomarker-tracks-recovery-treatment-resistant-depression\u0022\u003E\u003Cstrong\u003ERead the full story on the College of Engineering website.\u003C\/strong\u003E\u003C\/a\u003E\u003C\/p\u003E\r\n","summary":"","format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EHarnessing the power of explainable AI, researchers have unveiled the first insights into the complex workings of deep-brain stimulation therapy for severe depression.\u003C\/p\u003E\r\n","format":"limited_html"}],"field_summary_sentence":[{"value":"Harnessing the power of explainable AI, researchers have unveiled the first insights into the complex workings of deep-brain stimulation therapy for severe depression."}],"uid":"27446","created_gmt":"2023-09-18 19:57:10","changed_gmt":"2023-09-26 11:36:27","author":"Joshua Stewart","boilerplate_text":"","field_publication":"","field_article_url":"","dateline":{"date":"2023-09-20T00:00:00-04:00","iso_date":"2023-09-20T00:00:00-04:00","tz":"America\/New_York"},"extras":[],"hg_media":{"671741":{"id":"671741","type":"image","title":"Depression DBS Brain Illustration","body":"\u003Cp\u003EAn illustration created from scans of the white matter brain structure of a patient in the study by Georgia Tech, Mount Sinai, and Emory University researchers. The highlighted paths are the regions targeted in deep-brain stimulation therapy for treatment-resistant depression. Recordings of brain activity during treatment paired with new explainable AI tools can provide objective data about recovery to physicians. (Illustration: Mike Halerz, TeraPixel)\u003C\/p\u003E\r\n","created":"1695067711","gmt_created":"2023-09-18 20:08:31","changed":"1695222163","gmt_changed":"2023-09-20 15:02:43","alt":"Copper-colored illustration of a hair-like mass shaped like a brain. The strands are the white matter structure of a patient brain.  It\u0027s encircled by ones \u0026 zeros that connect to a bright spot in the frontal lobe with brightly lit pathways extending from that spot \u2014 the target pathways for a deep-brain stimulation therapy to treat severe depression. (Illustration: Mike Halerz, TeraPixel)","file":{"fid":"254849","name":"SCC-DBS-Copper-Brain-Illus-Mike-Halerz-TeraPixel_crop.jpg","image_path":"\/sites\/default\/files\/2023\/09\/18\/SCC-DBS-Copper-Brain-Illus-Mike-Halerz-TeraPixel_crop.jpg","image_full_path":"http:\/\/hg.gatech.edu\/\/sites\/default\/files\/2023\/09\/18\/SCC-DBS-Copper-Brain-Illus-Mike-Halerz-TeraPixel_crop.jpg","mime":"image\/jpeg","size":3164889,"path_740":"http:\/\/hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/2023\/09\/18\/SCC-DBS-Copper-Brain-Illus-Mike-Halerz-TeraPixel_crop.jpg?itok=b2EI1erz"}}},"media_ids":["671741"],"groups":[{"id":"1188","name":"Research Horizons"}],"categories":[{"id":"138","name":"Biotechnology, Health, Bioengineering, Genetics"},{"id":"145","name":"Engineering"},{"id":"135","name":"Research"}],"keywords":[{"id":"177256","name":"Chris Rozell"},{"id":"9024","name":"depression"},{"id":"189654","name":"deep brain stimulation"},{"id":"1925","name":"Electrical and Computer Engineering"},{"id":"594","name":"college of engineering"},{"id":"187915","name":"go-researchnews"},{"id":"187423","name":"go-bio"},{"id":"172970","name":"go-neuro"},{"id":"126591","name":"go-NeuralEngineering"},{"id":"126201","name":"go-neural"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EMedia Contact:\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Ca href=\u0022mailto:aisles3@gatech.edu\u0022\u003EAyana Isles\u003C\/a\u003E\u003Cbr \/\u003E\r\nMedia Relations\u003Cbr \/\u003E\r\n404.660.2927\u003C\/p\u003E\r\n","format":"limited_html"}],"email":["aisles3@gatech.edu"],"slides":[],"orientation":[],"userdata":""}}}