{"669184":{"#nid":"669184","#data":{"type":"event","title":"The School of Biological Sciences Fall 2023 Seminar Series presents Dr. Vanessa Sperandio","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EVanessa Sperandio, PhD\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003ERobert Turell Professor of Medical Microbiology and Immunology\u0026nbsp;And Department Chair\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EUniversity of Wisconsin | \u003Ca href=\u0022https:\/\/gatech.zoom.us\/j\/95147211615?pwd=RC9MclpGZlVKaTdidjBIUy84eDRPZz09\u0022\u003ELIVESTREAM\u003C\/a\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003EGut-microbiota membership is associated with diverse neuropsychological-diseases, including substance use disorders (SUDs). Unravelling mechanistic interactions between gut microbes and the host during psychostimulant use remains challenging. Here we show that cocaine exposure increases intestinal levels of norepinephrine, sensed through the bacterial adrenergic receptor QseC to promote virulence and intestinal colonization of \u003Cem\u003EC. rodentium\u003C\/em\u003E (a murine pathogen used as a surrogate animal model for EHEC), as well as intestinal colonization of commensal \u003C\/span\u003E\u003Cspan\u003Eg\u003C\/span\u003E\u003Cspan\u003E-Proteobacteria. This shift in microbiota-composition depletes the neuroactive metabolite glycine (used as a nitrogen source by \u003Cem\u003EC. rodentium \u003C\/em\u003Eand\/or \u003C\/span\u003E\u003Cspan\u003Eg\u003C\/span\u003E\u003Cspan\u003E-Proteobacteria) in the gut and cerebrospinal fluid, enhancing host cocaine-induced behaviors. Glycine repletion reversed this response, and intestinal colonization by \u003C\/span\u003E\u003Cspan\u003Eg\u003C\/span\u003E\u003Cspan\u003E-Proteobacteria unable to uptake glycine did not alter the host response to cocaine. Transcriptomic profiling indicates a role of microbiota modulated glycine levels in cocaine induced transcriptional plasticity in the nucleus accumbens through the glutamatergic transmission. Altogether, we introduce a mechanism by which intestinal bacteria alter the host\u2019s brain responses to cocaine that could be exploited to modulate reward-related brain circuits that contribute to SUDs.\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EHost: Dr. Marvin Whiteley\u003C\/p\u003E\r\n","summary":"","format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe highs and lows of enteric infections\u003C\/p\u003E\r\n","format":"limited_html"}],"field_summary_sentence":[{"value":"The highs and lows of enteric infections"}],"uid":"36506","created_gmt":"2023-08-25 18:16:54","changed_gmt":"2023-09-07 19:53:01","author":"rbailey74","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2023-09-21T11:00:00-04:00","event_time_end":"2023-09-21T12:00:00-04:00","event_time_end_last":"2023-09-21T12:00:00-04:00","gmt_time_start":"2023-09-21 15:00:00","gmt_time_end":"2023-09-21 16:00:00","gmt_time_end_last":"2023-09-21 16:00:00","rrule":null,"timezone":"America\/New_York"},"location":"Roger A. and Helen B Krone Engineered Biosystems Building, 950 Atlantic Drive, Atlanta, GA  30032, Room 1005","extras":["free_food"],"hg_media":{"671502":{"id":"671502","type":"image","title":"Venessa S","body":null,"created":"1693240328","gmt_created":"2023-08-28 16:32:08","changed":"1693240367","gmt_changed":"2023-08-28 16:32:47","alt":"Venessa S","file":{"fid":"254575","name":"Venessa S_1.jpg","image_path":"\/sites\/default\/files\/2023\/08\/28\/Venessa%20S_1.jpg","image_full_path":"http:\/\/hg.gatech.edu\/\/sites\/default\/files\/2023\/08\/28\/Venessa%20S_1.jpg","mime":"image\/jpeg","size":40853,"path_740":"http:\/\/hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/2023\/08\/28\/Venessa%20S_1.jpg?itok=xBCUkSuo"}}},"media_ids":["671502"],"groups":[{"id":"1275","name":"School of Biological Sciences"}],"categories":[],"keywords":[{"id":"188689","name":"Biological Sciences Seminar"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"177814","name":"Postdoc"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003EFor all questions and concerns please contact us at \u003Ca href=\u0022mailto:administrative@biosci.gatech.edu\u0022\u003Eadministrative@biosci.gatech.edu\u003C\/a\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}