{"667674":{"#nid":"667674","#data":{"type":"external_news","title":"Application of a quantitative framework to improve the accuracy of a bacterial infection model","body":[{"value":"\u003Cp\u003EModel systems are a cornerstone of microbiology. However, despite microbiology\u2019s heavy reliance on laboratory models, these systems are typically not analyzed systematically to improve their relevance. This limitation is a primary challenge to understand microbes\u2019 physiology in natural environments. This study, which includes members of Georgia Tech\u0027s \u003Ca href=\u0022https:\/\/microdynamics.gatech.edu\u0022\u003ECenter for Microbial Dynamics and Infection (CMDI)\u003C\/a\u003E, provides a proof of concept for generalizable approaches for model improvement using transcriptomic data of the pathogen\u0026nbsp;\u003Cem\u003EPseudomonas aeruginosa\u003C\/em\u003E\u0026nbsp;from sputum of patients with cystic fibrosis. The study\u0027s researchers include \u003Ca href=\u0022https:\/\/biosciences.gatech.edu\/people\/marvin-whiteley\u0022\u003EMarvin Whiteley\u003C\/a\u003E, professor in the \u003Ca href=\u0022https:\/\/biosciences.gatech.edu\u0022\u003ESchool of Biological Sciences\u003C\/a\u003E, Georgia Tech Bennie H. and Nelson D. Abell Chair in Molecular and Cellular Biology, \u003Ca href=\u0022https:\/\/gra.org\u0022\u003EGeorgia Research Alliance\u003C\/a\u003E\u0026nbsp;Eminent Scholar, and Co-Director, Emory-Children\u2019s Cystic Fibrosis Center; Other School of Biological Sciences and CMDI researchers include\u0026nbsp;\u003Ca href=\u0022https:\/\/microdynamics.gatech.edu\/gina-lewin-june-2021\u0022\u003EGina R. Lewin\u003C\/a\u003E, postdoctoral scholar, and research scientists\u0026nbsp;\u003Ca href=\u0022https:\/\/biosciences.gatech.edu\/people\/daniel-cornforth\u0022\u003EDaniel Cornforth\u003C\/a\u003E\u0026nbsp;and \u003Ca href=\u0022https:\/\/biosciences.gatech.edu\/people\/frances-diggle\u0022\u003EFrancis Diggle\u003C\/a\u003E.\u0026nbsp;\u003C\/p\u003E\r\n","summary":"","format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EModel systems are a cornerstone of microbiology. However, despite microbiology\u2019s heavy reliance on laboratory models, these systems are typically not analyzed systematically to improve their relevance. This limitation is a primary challenge to understand microbes\u2019 physiology in natural environments. This study, which includes members of Georgia Tech\u0027s \u003Ca href=\u0022https:\/\/microdynamics.gatech.edu\u0022\u003ECenter for Microbial Dynamics and Infection (CMDI)\u003C\/a\u003E, provides a proof of concept for generalizable approaches for model improvement using transcriptomic data of the pathogen\u0026nbsp;\u003Cem\u003EPseudomonas aeruginosa\u003C\/em\u003E\u0026nbsp;from sputum of patients with cystic fibrosis. The study\u0027s researchers include \u003Ca href=\u0022https:\/\/biosciences.gatech.edu\/people\/marvin-whiteley\u0022\u003EMarvin Whiteley\u003C\/a\u003E, professor in the \u003Ca href=\u0022https:\/\/biosciences.gatech.edu\u0022\u003ESchool of Biological Sciences\u003C\/a\u003E, Georgia Tech Bennie H. and Nelson D. Abell Chair in Molecular and Cellular Biology, \u003Ca href=\u0022https:\/\/gra.org\u0022\u003EGeorgia Research Alliance\u003C\/a\u003E Eminent Scholar, and Co-Director, Emory-Children\u2019s Cystic Fibrosis Center; Other School of Biological Sciences and CMDI researchers include\u0026nbsp;\u003Ca href=\u0022https:\/\/microdynamics.gatech.edu\/gina-lewin-june-2021\u0022\u003EGina R. Lewin\u003C\/a\u003E, postdoctoral scholar, and research scientists\u0026nbsp;\u003Ca href=\u0022https:\/\/biosciences.gatech.edu\/people\/daniel-cornforth\u0022\u003EDaniel Cornforth\u003C\/a\u003E\u0026nbsp;and \u003Ca href=\u0022https:\/\/biosciences.gatech.edu\/people\/frances-diggle\u0022\u003EFrancis Diggle\u003C\/a\u003E.\u0026nbsp;\u003C\/p\u003E\r\n","format":"limited_html"}],"field_summary_sentence":"","uid":"34434","created_gmt":"2023-05-08 15:11:06","changed_gmt":"2023-05-08 15:11:06","author":"Renay San Miguel","boilerplate_text":"","field_publication":"","publication":"Proceedings of the National Academy of Sciences ","field_article_url":"","publication_url":"https:\/\/www.pnas.org\/doi\/10.1073\/pnas.2221542120","dateline":{"date":"2023-05-01T00:00:00-04:00","iso_date":"2023-05-01T00:00:00-04:00","tz":"America\/New_York"},"extras":[],"groups":[{"id":"1278","name":"College of Sciences"},{"id":"1275","name":"School of Biological Sciences"}],"categories":[{"id":"135","name":"Research"}],"keywords":[{"id":"4896","name":"College of Sciences"},{"id":"166882","name":"School of Biological Sciences"},{"id":"192003","name":"Center for Microbial Dynamics and Infection (CMDI)"},{"id":"172754","name":"Marvin Whiteley"},{"id":"192593","name":"Gina R. Lewin"},{"id":"192594","name":"Francis Diggle"},{"id":"184346","name":"Daniel Cornforth"},{"id":"192595","name":"bacterial infection models"},{"id":"20251","name":"Proceedings of the National Academy of Sciences"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}