Microdroplet chemistry has received increasing attention for accelerated reactions at the air/solution interface in recent years. However, a large and significant category of reactions not demonstrated in microdroplets is the electrochemical reaction. This talk will discuss our progress toward microdroplet electrochemical strategies which include (i) a voltage-controlled interfacial microreactor that allows acceleration of electrochemical reactions for the first time; (ii) novel interfacial electrochemical reactions that address various long-standing isomeric problems in lipid isomer analysis; (iii) novel mass spectrometry screening platform that uses picomole-scale anodic corrosion of transition metal electrodes (e.g., Pd) to enable the rapid discovery of transition metal catalysis.