{"665781":{"#nid":"665781","#data":{"type":"event","title":"BioE PhD Defense Presentation- Rebecca Schneider","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor:\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EAndr\u0026eacute;s J. Garc\u0026iacute;a, PhD (Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee Members:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EJohn Blazeck, PhD (Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EWilbur A. Lam, MD, PhD (Emory University and Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EAnkur Singh, PhD (Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003ERoss Marklein, PhD (University of Georgia)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EHigh-throughput 3D on-chip potency assay for improved cell therapy product clinical prediction\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Ca name=\u0022_Toc439062360\u0022\u003ECell therapies offer promising strategies to treat diverse oncologic, inflammatory, and immune applications. Despite promising early phase clinical data, cell therapy candidates face new translational challenges, in part, due to a poor understanding of the cell therapy product during drug development and scale up. Current potency testing is often overly simplified and strongly biased by traditional 2D culture techniques. By engineering improved, well-defined, physiological-relevant \u003Cem\u003Ein vitro\u003C\/em\u003E systems, we aim to provide high-throughput and reproducible potency assays with improved outcome prediction of \u003Cem\u003Ein vivo\u003C\/em\u003E and\/or clinical response. We have demonstrated proof-of-concept of the on-chip platform by showing improved \u003Cem\u003Ein vitro\u003C\/em\u003E immunomodulatory prediction and stronger fidelity to \u003Cem\u003Ein vivo \u003C\/em\u003Esecretion compared to traditional 2D culture for n=9 mesenchymal stem\/stromal cell (MSC) donors. We have further evaluated n=60 MSC and MSC-derivative clinical samples using the on-chip platform and found secretion outcomes with greater correlation and\/or variance across donor-matched characteristics compared to 2D culture secretion. Future work will include platform clinical validation by evaluation of on-chip secretion correlation to patient-matched outcomes. The data presented here is in strong support of the value of the on-chip system to deliver scalable and high throughput cell product secretion information more predictive of \u003Cem\u003Ein vivo\u003C\/em\u003E and\/or clinical settings.\u003C\/a\u003E\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioE PhD Defense Presentation- \u0026quot;High-throughput 3D on-chip potency assay for improved cell therapy product clinical prediction\u0026quot; -Rebecca Schneider\u003C\/p\u003E\r\n","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022High-throughput 3D on-chip potency assay for improved cell therapy product clinical prediction\u0022"}],"uid":"27917","created_gmt":"2023-02-14 15:08:46","changed_gmt":"2023-02-14 15:08:46","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2023-02-28T09:00:00-05:00","event_time_end":"2023-02-28T11:00:00-05:00","event_time_end_last":"2023-02-28T11:00:00-05:00","gmt_time_start":"2023-02-28 14:00:00","gmt_time_end":"2023-02-28 16:00:00","gmt_time_end_last":"2023-02-28 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"172056","name":"go-BioE"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"10377","name":"Career\/Professional development"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}