{"665238":{"#nid":"665238","#data":{"type":"event","title":"Prof. Roy Goodacre (University of Liverpool)","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003ETitle:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003ELessons From Large-Scale Metabolic Phenotyping\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAbstract:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003ECentre for Metabolomics Research, Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, BioSciences Building, Crown St., Liverpool, UK, L69 7ZB\u003C\/p\u003E\r\n\r\n\u003Cp\u003EMetabolomics is a growing discipline that allows the analysis of the thousands of structural different small molecules found within a biological system. These metabolites can be measured using a variety of different analytical approaches and we have developed gas chromatography mass spectrometry (GC-MS) and liquid chromatography mass spectrometry (LC-MS) for this purpose [1].\u0026nbsp; I shall provide an overview of metabolomics and lessons learnt from of our large-scale human serum metabolome project where we profiled 1200 healthy individuals [2]. Using these protocols we then went on to profile another ~1200 ageing individuals and identified key metabolic dysregulation which were drivers behind human frailty, which were validated in a further ~760 ageing individuals [3].\u003C\/p\u003E\r\n\r\n\u003Cp\u003EIn parallel, we have been developing Raman and infrared microscopy in order to understand metabolic flux on a single cell level for bacterial community analysis.\u0026nbsp; Recent insights in metabolic flux analysis will be highlighted.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Seminar"}],"uid":"36417","created_gmt":"2023-01-30 15:07:42","changed_gmt":"2023-01-30 15:09:50","author":"tthacker6","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2023-02-13T15:30:00-05:00","event_time_end":"2023-02-13T16:30:00-05:00","event_time_end_last":"2023-02-13T16:30:00-05:00","gmt_time_start":"2023-02-13 20:30:00","gmt_time_end":"2023-02-13 21:30:00","gmt_time_end_last":"2023-02-13 21:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"85951","name":"School of Chemistry and Biochemistry"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EHosted by: Facundo Fernandez\u003C\/p\u003E\r\n","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}