{"663998":{"#nid":"663998","#data":{"type":"event","title":"PhD Defense by Stephen Thomas","body":[{"value":"\u003Cp\u003EIn partial fulfillment of the requirements for the degree of\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDoctor of Philosophy in Quantitative Biosciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003Ein the School of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EStephen Thomas\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDefends his thesis:\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ETitle: Linking Molecular Mechansims to Population-level Behavior using Mathematical Models of \u003Cem\u003EPseudomonas aeruginosa\u003C\/em\u003E\u003C\/strong\u003E\u003Cstrong\u003E Quorum Sensing\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EThursday, January 5, 2023\u003C\/p\u003E\r\n\r\n\u003Cp\u003E10:00am Eastern Time\u003C\/p\u003E\r\n\r\n\u003Cp\u003EEngineered Biosystems Building (EBB) Seminar Room (CHoA, 1005)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Ca href=\u0022https:\/\/gatech.zoom.us\/j\/95288429704\u0022\u003Ehttps:\/\/gatech.zoom.us\/j\/95288429704\u003C\/a\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EOpen to the Community\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAdvisor:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Sam P. Brown\u003Cbr \/\u003E\r\nSchool of Biological Sciences\u003Cbr \/\u003E\r\nGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee Members:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Joshua S. Weitz\u003Cbr \/\u003E\r\nSchool of Biological Sciences\u003Cbr \/\u003E\r\nGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Steve Diggle\u003Cbr \/\u003E\r\nSchool of Biological Sciences\u003Cbr \/\u003E\r\nGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Marvin Whitely\u003Cbr \/\u003E\r\nSchool of Biological Sciences\u003Cbr \/\u003E\r\nGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Josephine Chandler\u003Cbr \/\u003E\r\nDept. Of Molecular Biosciences\u003Cbr \/\u003E\r\nUniversity of Kansas\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAbstract:\u003C\/strong\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EBacterial cells of many species communicate with each other by exchanging diffusible signal molecules. This mechanism, known as quorum sensing, has been well-studied at the level of specific molecular interactions. We now understand how those interactions shape the creation of and response to signal molecules in model organisms such as \u003Cem\u003EPseudomonas aeruginosa. \u003C\/em\u003EWhat is less clear is how quorum sensing operates at the population level. How can we characterize population-level quorum sensing responses to defined environmental variables? What types of responses are possible? What are the important constraints on those responses?\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EThe chapters that follow contribute answers to some of those questions. They focus on characterizing and modeling the overall population response to quorum sensing, and how heterogenous individual cells contribute systematically to that response. The results combine experimental observations conducted with \u003Cem\u003EP. aeruginosa\u003C\/em\u003E and mathematical models. The models allow interpretation of the data, identification of key qualities and quantities, and exploration of alternatives.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EChapter 2 demonstrates that both populations and individual cells are not limited to the on or off reaction implied by simple quorum sensing narratives. Rather, cells and populations can fine-tune their behavior, giving them a richer repertoire of responses to variable environments. Chapter 3 examines the ways multiple quorum sensing systems within a species can interact and how the specific form of those interactions can significantly affect population-level behavior. Chapter 4 reveals temporal diversity in cells\u0026rsquo; responses and suggests a way in which this behavior may benefit the population in unpredictable environments. Finally, Chapter 5 discusses key elements common to all of the chapters, and it outlines a path for future research that can extend their findings.\u0026nbsp;\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Linking Molecular Mechansims to Population-level Behavior using Mathematical Models of Pseudomonas aeruginosa Quorum Sensing"}],"uid":"27707","created_gmt":"2022-12-20 16:41:36","changed_gmt":"2022-12-20 16:41:36","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2023-01-05T10:00:00-05:00","event_time_end":"2023-01-05T12:00:00-05:00","event_time_end_last":"2023-01-05T12:00:00-05:00","gmt_time_start":"2023-01-05 15:00:00","gmt_time_end":"2023-01-05 17:00:00","gmt_time_end_last":"2023-01-05 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"100811","name":"Phd Defense"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}