{"663331":{"#nid":"663331","#data":{"type":"news","title":"Closing the Loop to Target Brain Glioblastomas","body":[{"value":"\u003Cp\u003E\u0026ldquo;Closing the loop\u0026rdquo; has become one of the jargony cliches of the business world. But in the world of cancer immunotherapy, closing the loop could be an innovation that unlocks powerful therapies for hard-to-treat brain cancers called glioblastomas.\u003C\/p\u003E\r\n\r\n\u003Cp\u003EResearchers at Georgia Tech and Emory University have developed a system that uses ultrasound-induced microbubbles to help a powerful immunotherapy target brain tumors and a custom algorithm to continuously fine tune the bubbles for maximum impact.\u003C\/p\u003E\r\n\r\n\u003Cp\u003ETheir closed-loop controlled focused ultrasound system proved effective in boosting survival rates in mouse models, including eradicating the entire tumor in at least one case. They described their approach Nov. 18 in the journal Science Advances.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Ca href=\u0022https:\/\/coe.gatech.edu\/news\/2022\/11\/closing-loop-target-brain-glioblastomas\u0022\u003E\u003Cstrong\u003ERead the full story on the College of Engineering website.\u003C\/strong\u003E\u003C\/a\u003E\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EAlgorithm-controlled focused ultrasound system uses microbubbles to open a pathway for a powerful immunotherapy to reach brain tumors.\u003C\/p\u003E\r\n","format":"limited_html"}],"field_summary_sentence":[{"value":"Algorithm-controlled focused ultrasound system uses microbubbles to open a pathway for a powerful immunotherapy to reach brain tumors"}],"uid":"27446","created_gmt":"2022-11-18 20:12:04","changed_gmt":"2022-11-18 20:12:32","author":"Joshua Stewart","boilerplate_text":"","field_publication":"","field_article_url":"","dateline":{"date":"2022-11-18T00:00:00-05:00","iso_date":"2022-11-18T00:00:00-05:00","tz":"America\/New_York"},"extras":[],"hg_media":{"663327":{"id":"663327","type":"image","title":"Closed-Loop Controlled Focused Ultrasound for Immunotherapy","body":null,"created":"1668801995","gmt_created":"2022-11-18 20:06:35","changed":"1668801995","gmt_changed":"2022-11-18 20:06:35","alt":"Ph.D. student Hohyun \u0022Henry\u0022 Lee adjusts the metal arm holding the ultrasound transducer for his algorithm-controlled focused ultrasound system. Associate Professor Costas Arvanitis looks at data on a computer screen in the background.","file":{"fid":"251103","name":"_MG_6259(edited).jpg","image_path":"\/sites\/default\/files\/images\/_MG_6259%28edited%29.jpg","image_full_path":"http:\/\/hg.gatech.edu\/\/sites\/default\/files\/images\/_MG_6259%28edited%29.jpg","mime":"image\/jpeg","size":1707027,"path_740":"http:\/\/hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/_MG_6259%28edited%29.jpg?itok=rKLr9I9m"}}},"media_ids":["663327"],"groups":[{"id":"1237","name":"College of Engineering"},{"id":"1188","name":"Research Horizons"}],"categories":[],"keywords":[{"id":"191666","name":"Costas Arvanitis"},{"id":"28521","name":"Brain Cancer"},{"id":"28561","name":"Glioblastoma"},{"id":"178960","name":"focused ultrasound"},{"id":"4514","name":"immunotherapy"},{"id":"178946","name":"blood-brain barrier"},{"id":"187423","name":"go-bio"},{"id":"187915","name":"go-researchnews"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:jstewart@gatech.edu\u0022\u003EJoshua Stewart\u003C\/a\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003ECollege of Engineering\u003C\/p\u003E\r\n","format":"limited_html"}],"email":["jstewart@gatech.edu"],"slides":[],"orientation":[],"userdata":""}}}