{"661193":{"#nid":"661193","#data":{"type":"event","title":"BioE PhD Proposal - Afsane Radmand","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor: \u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EJames E. Dahlman, Ph.D. Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee Members:\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EPhilip J. Santangelo, Ph.D.\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EJulie A. Champion, Ph.D.\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDepartment of Chemical and Biomolecular Engineering, Georgia Institute of Technology\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EWilber Lam, Ph.D. \u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDepartment of Biomedical Engineering, Georgia Institute of Technology and Emory University\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EBrandon Dixon, Ph.D.\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDepartment of Mechanical Engineering,\u0026nbsp;Georgia Institute of Technology\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ENext-generation lipid nanoparticle formulations for non-liver delivery of nucleic acid-based therapies and vaccines \u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EThe clinical application of lipid nanoparticles (LNPs) delivering RNA therapies has advanced remarkably over the past few decades with the Food and Drug Administration (FDA) approval of ONPATTRO\u0026reg; in 2018 for treating liver genetic disease following systemic administration and the most recent COVID-19 vaccines developed by Moderna Therapeutics Inc. and Pfizer-BioNTech in 2021. Despite the success of first-generation LNP-RNA therapies, there still remains needs to rationally design next-generation LNP formulations for systemic non-liver delivery and for vaccination against other malignant diseases such as respiratory syncytial virus (RSV). In this work, we aimed to (i) identify helper lipid design rules and biological response for systemic lung mRNA delivery of LNPs, (ii) investigate the effect of cationic lipids in LNP formulation on systemic \u003Cem\u003Ein vivo\u003C\/em\u003E non-liver tropism, and (iii) develop a mRNA-based LNP vaccine for RSV. This work will establish the foundation towards two crucial objectives: (1) exploiting lipid nanoparticle design rules for systemic \u003Cem\u003Enon-liver \u003C\/em\u003Edelivery of nucleic acid-based therapies (2) determining factors for LNP mRNA-based vaccine immunogenicity which will allow for taking a leap towards developing clinically relevant nucleic acid-based vaccines. \u0026nbsp;\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioE PhD Proposal - \u0026quot;Next-generation lipid nanoparticle formulations for non-liver delivery of nucleic acid-based therapies and vaccines \u0026nbsp;\u0026quot; - Afsane Radmand\u003C\/p\u003E\r\n","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Next-generation lipid nanoparticle formulations for non-liver delivery of nucleic acid-based therapies and vaccines  \u0022"}],"uid":"27917","created_gmt":"2022-09-14 15:45:37","changed_gmt":"2022-09-14 15:45:37","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2022-10-03T12:00:00-04:00","event_time_end":"2022-10-03T14:00:00-04:00","event_time_end_last":"2022-10-03T14:00:00-04:00","gmt_time_start":"2022-10-03 16:00:00","gmt_time_end":"2022-10-03 18:00:00","gmt_time_end_last":"2022-10-03 18:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"172056","name":"go-BioE"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"10377","name":"Career\/Professional development"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}