{"658192":{"#nid":"658192","#data":{"type":"event","title":"BioE PhD Proposal- Michelle Quizon","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EAndr\u0026eacute;s J. Garc\u0026iacute;a, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EThesis Committee:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EEdward A. Botchwey, Ph.D. (Georgia Institute of Technology \u0026amp; Emory University)\u003C\/p\u003E\r\n\r\n\u003Cp\u003ERebecca D. Levit, M.D. (Emory University)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EEdward A. Phelps, Ph.D. (University of Florida)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EKrishnendu Roy, Ph.D. (Georgia Institute of Technology \u0026amp; Emory University)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ESynthetic hydrogels for islet vascularization and engraftment in the subcutaneous space\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Type 1 diabetes (T1D) is a chronic, debilitating disease\u0026nbsp; characterized by the autoimmune destruction of insulin-producing b-cells located within pancreatic islets. The gold standard for T1D cell therapy is clinical islet transplantation (CIT), the infusion of islets through the hepatic portal vein. While CIT recipients demonstrate enhanced blood glucose control,\u0026nbsp; the procedure is limited to a marginal subset of T1D patients, in part due to the inhospitable nature of the intrahepatic site Indeed, an expected \u0026gt;60% loss of therapeutic cargo is expected within three days following transplantation. Thus, there is a significant need to establish an alternative extrahepatic transplant site that supports the engraftment of islets.\u003C\/p\u003E\r\n\r\n\u003Cp\u003EThe subcutaneous space is an attractive extrahepatic transplant site for T1D cell therapy given its high clinical potential in terms of surgical accessibility, ease of monitoring, and convenience for replenishment and\/or retrieval of therapeutic cargo. However, the unmodified subcutaneous space lacks adequate vascularization necessary to preserve functional islets. An elegant, facile strategy to promote neovascularization is the biomaterial-mediated delivery of proangiogenic factors such as vascular endothelial growth factor (VEGF). The objective of this project is to engineer injectable VEGF-delivering synthetic poly(ethylene glycol) [PEG] hydrogels that promote islet vascularization, engraftment, and function in the subcutaneous space. My central hypothesis is that the VEGF-delivering hydrogel can be tuned to do so.\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003ETo test my hypothesis, I will first identify VEGF-PEG hydrogel formulations that support islet vascularization using an \u003Cem\u003Ein vitro\u003C\/em\u003E platform of vascularized islets. Next, I will evaluate lead VEGF-PEG hydrogel formulations in their ability to promote allogeneic islet vascularization, engraftment, and function in the subcutaneous spaces of diabetic rats and nondiabetic pigs. My work will result in an optimized injectable hydrogel for islet vascularization, engraftment, and function. Most significantly, it will provide a solid foundation for future work in a translational diabetic large animal model.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioE PhD Proposal-\u0026nbsp;\u0026quot;Synthetic hydrogels for islet vascularization and engraftment in the subcutaneous space\u0026quot;-\u0026nbsp; Michelle Quizon\u003C\/p\u003E\r\n","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Synthetic hydrogels for islet vascularization and engraftment in the subcutaneous space\u0022"}],"uid":"27917","created_gmt":"2022-05-13 14:12:54","changed_gmt":"2022-05-13 14:12:54","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2022-05-31T12:00:00-04:00","event_time_end":"2022-05-31T14:00:00-04:00","event_time_end_last":"2022-05-31T14:00:00-04:00","gmt_time_start":"2022-05-31 16:00:00","gmt_time_end":"2022-05-31 18:00:00","gmt_time_end_last":"2022-05-31 18:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"172056","name":"go-BioE"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"10377","name":"Career\/Professional development"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}