{"656929":{"#nid":"656929","#data":{"type":"event","title":"PhD Defense by Shea McMurtry","body":[{"value":"\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EIn partial fulfillment of the requirements for the degree of\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDoctor of Philosophy in Applied Physiology\u003C\/p\u003E\r\n\r\n\u003Cp\u003EIn the\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EShea McMurtry\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EWill defend her dissertation\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EA novel approach to restore proprioceptive feedback following spinal cord injuries using eccentric training\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EFriday, April 15\u003Csup\u003Eth\u003C\/sup\u003E, 2022\u003C\/p\u003E\r\n\r\n\u003Cp\u003E1:00 PM EST\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EIn person: \u003C\/strong\u003EApplied Physiology Building (555 14\u003Csup\u003Eth\u003C\/sup\u003E\u0026nbsp;st.), Room 1253\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EVirtual:\u003C\/strong\u003E \u003Ca href=\u0022https:\/\/bluejeans.com\/282178122\/2722\u0022\u003Ehttps:\/\/bluejeans.com\/282178122\/2722\u003C\/a\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003Cstrong\u003EThesis Advisor:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003ET Richard Nichols, Ph.D.\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cem\u003EGeorgia Institute of Technology\u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee Members:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003ETim Cope, Ph.D.\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cem\u003EGeorgia Institute of Technology\u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EBoris Prilutsky, Ph.D.\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cem\u003EGeorgia Institute of Technology\u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDena Howland, Ph.D.\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDept. of Neurological Surgery and Anatomical Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cem\u003EUniversity of Louisville\u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EMark Lyle, Ph.D.\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Medicine\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cem\u003EEmory University\u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAbstract\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EIncomplete spinal cord injuries (SCI) lead to a variety of motor deficits including problems with ambulation. A further understanding of the pathophysiology leading to these deficits is required to develop therapies. Previous research in our lab using the decerebrate preparation shows that inhibitory force feedback (iFFB) is upregulated and distributed across hindlimb muscles in one distinct pattern following lateral hemisection (LHX). Spinally intact animals show mostly balanced flexible patterns of iFFB with a different pattern during stepping. Data from previous studies also support the hypothesis that inhibitory force feedback is increased during walking down slope, a complex task that features eccentric work of extensor muscles.\u003C\/p\u003E\r\n\r\n\u003Cp\u003EThis project is a component of a comprehensive study of the effects of partial spinal cord injury on motor behavior and the underlying mechanisms, and possible rehabilitation strategies. The efficacy and specificity of eccentric training in normalizing the organization of proprioceptive feedback and its relationship to improvements in motor behavior were tested. This was conducted in conjunction with Dr. Dena Howland and her lab, who performed the spinal injuries, training, kinematic analyses and histology. Eccentric muscle contractions are essential for walking over different kinds of terrain and are prominent during the weight acceptance (E2) phase. Animals with LHX showed an overall increased flexion throughout E1 and E2 as well as changes in limb coordination possibly due to a decrease in limb stiffness from the amplified force feedback.\u003C\/p\u003E\r\n\r\n\u003Cp\u003EThis project used mechanographic methods to investigate changes in reflex stiffness and heterogenic force feedback following a LHX across various training protocols. The injury led to an increase in inhibitory force feedback onto ankle extensors, and a delayed increase in the stretch reflexes in the same muscles. Both eccentric and level training induced plasticity in reflex pathways, but eccentric training was more effective in returning the strength and distribution of proprioceptive feedback toward that observed in spinally intact animals. These results further suggest that the reorganization of the force feedback network is likely to play a major role mediating the motor deficits observed during the stance phase of locomotion, and that eccentric training can restore the animal\u0026rsquo;s ability to modulate proprioception during complex tasks following spinal cord injury.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"A novel approach to restore proprioceptive feedback following spinal cord injuries using eccentric training"}],"uid":"27707","created_gmt":"2022-04-01 17:24:44","changed_gmt":"2022-04-01 17:24:44","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2022-04-15T14:00:00-04:00","event_time_end":"2022-04-15T16:00:00-04:00","event_time_end_last":"2022-04-15T16:00:00-04:00","gmt_time_start":"2022-04-15 18:00:00","gmt_time_end":"2022-04-15 20:00:00","gmt_time_end_last":"2022-04-15 20:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"100811","name":"Phd Defense"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}