{"656494":{"#nid":"656494","#data":{"type":"event","title":"PhD Defense by Haley Rae Steele","body":[{"value":"\u003Cp\u003EIn partial fulfillment of the requirements for the degree of\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDoctor of Philosophy in Biology\u003C\/p\u003E\r\n\r\n\u003Cp\u003EIn the\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EHaley Rae Steele\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EWill defend her dissertation\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EUnderstanding The Role Mas-Related G Protein-Coupled Receptors Play\u003C\/p\u003E\r\n\r\n\u003Cp\u003EIn Mediating Itch Sensation\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E5, April, 2022\u003C\/p\u003E\r\n\r\n\u003Cp\u003E2:00 PM\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EEBB CHOA Seminar Room or BlueJeans Link:\u0026nbsp;\u003Ca href=\u0022https:\/\/bluejeans.com\/573349989\/1538\u0022\u003Ehttps:\/\/bluejeans.com\/573349989\/1538\u003C\/a\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003Cstrong\u003EThesis Advisor:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003ELiang Han, Ph.D.\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee Members:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003ETodd Streelman, Ph.D.\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003ETim Cope, Ph.D.\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EYuhong Fan, Ph.D.\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EMark Wheeler, Ph.D.\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Psychology\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EABSTRACT:\u003C\/strong\u003E Although chronic itch is the most common reason for visiting the dermatologist, there remain few effective treatments. Glabrous skin itch, which occurs on the palms of hands and soles of feet, is extremely debilitating. However, despite arising from a variety of medical conditions (plantar and palmar psoriasis, dyshidrosis, and cholestasis), it has attracted little attention within the field due to a lack of methodology. Therefore, to identify the neuronal populations mediating glabrous skin itch we examined the central and peripheral innervation pattern of three previously identified itch-sensing neurons (MrgprA3\u003Csup\u003E+\u003C\/sup\u003E, MrgprD\u003Csup\u003E+\u003C\/sup\u003E, and MrgprC11\u003Csup\u003E+\u003C\/sup\u003E). We found that both MrgprD\u003Csup\u003E+\u003C\/sup\u003E and MrgprC11\u003Csup\u003E+\u003C\/sup\u003E sensory neurons densely innervate glabrous skin, while MrgprA3\u003Csup\u003E+\u003C\/sup\u003E sensory neurons do so only very sparsely. These results indicate, for the first time, the potential mechanistic differences that exist between hairy and glabrous skin itch. To investigate and the mechanisms of glabrous skin itch, we developed novel acute and chronic mouse behavioral assays to examine itch sensation arising from the glabrous skin of the plantar hindpaw. We found that mice exhibit specific biting behavior in response to itch-agonists and licking in response to pain-agonists.\u0026nbsp; Using this assay, we then demonstrated that specific-activation of MrgprA3\u003Csup\u003E+\u003C\/sup\u003E and MrgprD\u003Csup\u003E+\u003C\/sup\u003E nerves in the glabrous skin do not induce biting behavior, suggesting that they do not mediate glabrous skin itch. In contrast, we found that activation of MrgprC11\u003Csup\u003E+\u003C\/sup\u003E neurons induced significant dose-dependent biting (itch) behaviors in glabrous skin. Finally, we found that ablation of MrgprC11\u003Csup\u003E+\u003C\/sup\u003E neurons almost completely abolishes both acute and chronic glabrous skin itch. These results suggest that MrgprC11\u003Csup\u003E+\u003C\/sup\u003E neurons are a major mediator of glabrous skin itch. In summary, our findings reveal new avenues for future glabrous skin itch study and the development of glabrous-skin specific anti-itch therapies.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Understanding The Role Mas-Related G Protein-Coupled Receptors Play  In Mediating Itch Sensation"}],"uid":"27707","created_gmt":"2022-03-21 15:55:04","changed_gmt":"2022-03-21 15:55:04","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2022-04-05T15:00:00-04:00","event_time_end":"2022-04-05T17:00:00-04:00","event_time_end_last":"2022-04-05T17:00:00-04:00","gmt_time_start":"2022-04-05 19:00:00","gmt_time_end":"2022-04-05 21:00:00","gmt_time_end_last":"2022-04-05 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"100811","name":"Phd Defense"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}