{"656036":{"#nid":"656036","#data":{"type":"event","title":"CMDI Seminar Series: Stephen Dolan","body":[{"value":"\u003Cp\u003E\u003Cem\u003EPseudomonas aeruginosa\u0026nbsp;\u003C\/em\u003E(\u003Cem\u003EPa\u003C\/em\u003E)\u0026nbsp;is the most prevalent and persistent microorganism isolated from cystic fibrosis (CF) sputum and is a leading cause of mortality in CF patients.\u0026nbsp;Approximately 15% of people with\u0026nbsp;CF\u0026nbsp;are infected with\u0026nbsp;\u003Cem\u003EAspergillus fumigatus\u003C\/em\u003E\u0026nbsp;(\u003Cem\u003EAf\u003C\/em\u003E), a devastating human fungal pathogen.\u0026nbsp;\u003Cem\u003EAf\u0026nbsp;\u003C\/em\u003Ecan accelerate lung function decline in people with CF, and some of these\u0026nbsp;\u003Cem\u003EAf\u003C\/em\u003E\u0026nbsp;infected patients will develop allergic bronchio-pulmonary aspergillosis, a hypersensitivity fungal lung disease.\u0026nbsp;Clinical evidence suggests that the co-isolation of both\u0026nbsp;\u003Cem\u003EPa\u003C\/em\u003E\u0026nbsp;and\u0026nbsp;\u003Cem\u003EAf\u003C\/em\u003E\u0026nbsp;indicates a poorer prognosis, but the exact reason for this is unclear. Using multi-omics approaches combined with reverse genetics,\u0026nbsp;this work aims to understand how the\u0026nbsp;physiology\u0026nbsp;of both\u0026nbsp;\u003Cem\u003EPa\u003C\/em\u003E\u0026nbsp;and\u0026nbsp;\u003Cem\u003EAf\u003C\/em\u003E\u0026nbsp;change in co-culture when compared to monoculture, and to dissect the specific cues which drive these physiological changes. Together, these data will begin to answer the fundamental question of how coinfecting microbes interact during polymicrobial infection.\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EDefining mechanisms of fungal-bacterial interactions during infections\u003C\/p\u003E\r\n","format":"limited_html"}],"field_summary_sentence":[{"value":"CMDI Seminar Series 2022"}],"uid":"35021","created_gmt":"2022-03-04 14:02:13","changed_gmt":"2022-03-04 14:21:35","author":"mavdonina3","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2022-03-04T15:00:00-05:00","event_time_end":"2022-03-04T16:00:00-05:00","event_time_end_last":"2022-03-04T16:00:00-05:00","gmt_time_start":"2022-03-04 20:00:00","gmt_time_end":"2022-03-04 21:00:00","gmt_time_end_last":"2022-03-04 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}