{"65525":{"#nid":"65525","#data":{"type":"event","title":"GaP Seminar - The Multiple Personalities of Doxorubicin: An Examination of\u00a0Redox Regulation in Cancer Treatment","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u003Cem\u003E\u0026nbsp;\u003C\/em\u003ENnenna Finn\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EAdvisor:\u0026nbsp; \u003C\/strong\u003EMelissa L. Kemp\u003C\/p\u003E\u003Cp\u003E\u003Cem\u003EAbstract:\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003EDoxorubicin is a well known chemotherapeutic agent used in the treatment of a variety of cancers. Previous research has identified most of the components that comprise the doxorubicin bioactivation network; however, adaptation of the network to changes in doxorubicin treatment or to patient-specific changes in network components is much less understood. We present a model of doxorubicin bioactivation in leukemia cells that illustrates the dual-nature of doxorubicin treatment, and highlights pharmacological intervention strategies for promoting or impeding doxorubicin-induced cytotoxicity in cancer cells.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EGaP Seminar Series\u003C\/p\u003E\u003Cp\u003ENnenna Finn - \u0022The Multiple Personalities of Doxorubicin: An Examination of\u0026nbsp;Redox Regulation in Cancer Treatment\u0022\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Nenna Finn"}],"uid":"27195","created_gmt":"2011-04-12 10:39:50","changed_gmt":"2016-10-08 01:54:46","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2011-04-13T13:00:00-04:00","event_time_end":"2011-04-13T13:30:00-04:00","event_time_end_last":"2011-04-13T13:30:00-04:00","gmt_time_start":"2011-04-13 17:00:00","gmt_time_end":"2011-04-13 17:30:00","gmt_time_end_last":"2011-04-13 17:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[{"id":"12772","name":"GaP Seminar Series"},{"id":"248","name":"IBB"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EManu Platt\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}