{"648764":{"#nid":"648764","#data":{"type":"event","title":"BioE PhD Proposal Presentation- Lucinda Peng","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor\u003C\/strong\u003E: Hang Lu, Ph.D.\u003Cbr \/\u003E\r\nSchool of Chemical \u0026amp; Biomolecular Engineering, Georgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee members\u003C\/strong\u003E:\u003Cbr \/\u003E\r\nDaniel Goldman, Ph.D.\u003Cbr \/\u003E\r\nSchool of Physics, Georgia Institute of Technology\u003Cbr \/\u003E\r\nPatrick McGrath, Ph.D.\u003Cbr \/\u003E\r\nSchool of Biological Sciences, Georgia Institute of Technology\u003Cbr \/\u003E\r\nSimon Sponberg, Ph.D.\u003Cbr \/\u003E\r\nSchool of Physics, Georgia Institute of Technology\u003Cbr \/\u003E\r\nLena Ting, Ph.D.\u003Cbr \/\u003E\r\nWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EEngineered imaging and behavior assays to study effects of genes and environment on neurodegeneration\u003C\/strong\u003E\u003Cbr \/\u003E\r\nEnvironmental and genetic factors are two main contributors to disease pathology, including neurodegeneration. In particular, particulate matter exposure has been linked with many adverse health effects, including Parkinson\u0026#39;s disease. However, the diversity of genetic backgrounds and environmental exposures make the link between the two hard to study in humans. We use the model organism\u003Cem\u003E, C. elegans\u003C\/em\u003E\u0026nbsp;to tightly control genetic background and environmental exposure and measure the resulting neurodegeneration. Existing systems cannot monitor the development and neurodegeneration of individuals. This work will focus on the effect of traffic-related PM exposure on Parkinson\u0026#39;s disease related neurodegeneration and behavioral decline. The objective of my thesis is to engineer a system which can record the long-term development and behavior of worms during exposure to oxy-PAH, measure the subsequent neurodegeneration through a physically challenging assay which requires sensorimotor integration, and assess the functional integrity of neurons and link that to changes in behavior. This system will allow for linking environmental toxins with cellular stress mechanisms, neural degeneration, and behavior of individuals.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioE PhD Proposal Presentation- \u0026quot;Engineered imaging and behavior assays to study effects of genes and environment on neurodegeneration\u0026quot; - Lucinda Peng\u003C\/p\u003E\r\n","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Engineered imaging and behavior assays to study effects of genes and environment on neurodegeneration\u0022"}],"uid":"27917","created_gmt":"2021-07-14 18:11:17","changed_gmt":"2021-07-14 18:11:17","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2021-07-15T14:00:00-04:00","event_time_end":"2021-07-15T16:00:00-04:00","event_time_end_last":"2021-07-15T16:00:00-04:00","gmt_time_start":"2021-07-15 18:00:00","gmt_time_end":"2021-07-15 20:00:00","gmt_time_end_last":"2021-07-15 20:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"172056","name":"go-BioE"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"10377","name":"Career\/Professional development"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}