{"648733":{"#nid":"648733","#data":{"type":"event","title":"Ph.D. Proposal Oral Exam - Adam  Wang","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003ETitle:\u0026nbsp; \u003C\/strong\u003E\u003Cem\u003ECMOS Multi-Modal Cellular and Electrochemical Sensing\/Actuating Array with Integrated Microfluidics for Sample Manipulation\u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee:\u0026nbsp; \u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Wang, Advisor\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Inan, Chair\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Swaminathan\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAbstract: \u003C\/strong\u003EThe objective of the proposed research is to further revolutionize silicon-based multi-modality sensor\/actuating arrays for emerging applications.\u0026nbsp;Understanding complex multi-physical cellular responses is essential for numerous applications in biological\/biomedical science research and technology development, requiringcell-based biosensors that are widely used to augment molecular detections. They detect and characterize various biomolecules using living cells or tissues\u0026nbsp;massively paralleled cell interfacing platforms with multi-parametric sensing. Recently, CMOS biosensors with single\/multi-modality have been reported. However, most CMOS sensors are only single-modal which cannot capture multi-parametric cellular responses, and yield limited cell information. With multi-modal sensing, a sensor can real-time monitor cellular potential, impedance, and fluorescence responses to accurately capture cell activities, growth\/viability, and physiology states. In this proposal, studies on electrode-electrolyte interfaces and several circuit and system innovations are presented to holistically house and characterize cells. These proposed techniques can achieve multi-modalities to characterize with low noise from the electrode-electrolyte interfacial impedance different cell physiological responses including extracellular\/intracellular voltage recording, cellular impedance, optical detection. I plan on developing a CMOS multi-modal cellular and electrochemical sensing\/actuating array with integrated microfluidics. The combined microfluidic\/CMOS platform will allow for the precise control of the quantity of specimens with minimal sample volume ranging from pL to mL levels, offering a high-resolution, low-cost, and high throughput methodology while holistically analyzing biological\/molecular species.\u0026nbsp;\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"CMOS Multi-Modal Cellular and Electrochemical Sensing\/Actuating Array with Integrated Microfluidics for Sample Manipulation"}],"uid":"28475","created_gmt":"2021-07-13 21:02:42","changed_gmt":"2021-07-13 21:02:42","author":"Daniela Staiculescu","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2021-07-22T11:00:00-04:00","event_time_end":"2021-07-22T13:00:00-04:00","event_time_end_last":"2021-07-22T13:00:00-04:00","gmt_time_start":"2021-07-22 15:00:00","gmt_time_end":"2021-07-22 17:00:00","gmt_time_end_last":"2021-07-22 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"434371","name":"ECE Ph.D. Proposal Oral Exams"}],"categories":[],"keywords":[{"id":"102851","name":"Phd proposal"},{"id":"1808","name":"graduate students"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78771","name":"Public"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}