{"648487":{"#nid":"648487","#data":{"type":"event","title":"PhD Proposal by Haejun Han","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EBioE Ph.D. Thesis\u0026nbsp;Proposal\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EHaejun Han\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003ETuesday, July 13, 2021, 10:00 AM\u0026nbsp;EST\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003ELink:\u0026nbsp;\u003Ca href=\u0022https:\/\/bluejeans.com\/6742648471\u0022\u003Ehttps:\/\/bluejeans.com\/6742648471\u003C\/a\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAdvisor:\u003C\/strong\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EHang Lu, Ph.D.\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Chemical \u0026amp; Biomolecular Engineering, Georgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee Members:\u0026nbsp;\u003C\/strong\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGhassan AlRegib, Ph.D.\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Electrical and Computer Engineering, Georgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EPatrick\u0026nbsp;McGrath, Ph.D.\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences, Georgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EEva Dyer, Ph.D.\u003C\/p\u003E\r\n\r\n\u003Cp\u003EWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EOliver Hobert, Ph.D.\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDepartment of Biochemistry and Molecular Biophysics, Columbia University\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EInvestigating the influence of structural connectivity of nervous system on circuit-level neuronal activity and behavior of \u003Cem\u003EC. elegans\u003C\/em\u003E\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EStructural connectivity\u0026nbsp;in\u0026nbsp;the brain\u0026nbsp;is undoubtedly the basis of functional connectivity and behavior of\u0026nbsp;animals.\u0026nbsp;However, the relationship\u0026nbsp;between those three components is rarely studied at\u0026nbsp;the\u0026nbsp;individual level.\u0026nbsp;This study aims to develop\u0026nbsp;experimental and analytic frameworks to investigate\u0026nbsp;these\u0026nbsp;relationships\u0026nbsp;in roundworm,\u0026nbsp;\u003Cem\u003ECaenorhabditis elegans\u0026nbsp;\u003C\/em\u003Eto answer\u0026nbsp;an\u0026nbsp;important biological question:\u0026nbsp;does the individuality in neuronal activity and behavior come from the variation in structural connectivity?\u0026nbsp;In\u0026nbsp;aim 1, a deep learning-based\u0026nbsp;image restoration\u0026nbsp;pipeline will be developed to enable the\u0026nbsp;low-resolution\u0026nbsp;functional imaging of neural activity of freely\u0026nbsp;behaving\u0026nbsp;animals. In\u0026nbsp;aim 2, a computational software will be developed to facilitate\u0026nbsp;the\u0026nbsp;automated segmentation and\u0026nbsp;extensive quantification\u0026nbsp;of synapse images.\u0026nbsp;By putting these computational pipelines together, with previously established microfluidic devices,\u0026nbsp;the question above will be addressed\u0026nbsp;in the context of the noxious chemical avoidance response of\u0026nbsp;\u003Cem\u003EC. elegans.\u0026nbsp;\u003C\/em\u003EThis\u0026nbsp;work will contribute to a\u0026nbsp;better understanding of how\u0026nbsp;much\u0026nbsp;the variation in brain structure translates to the\u0026nbsp;functional connectivity\u0026nbsp;and behavior\u0026nbsp;on an\u0026nbsp;individual level.\u0026nbsp;\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Investigating the influence of structural connectivity of nervous system on circuit-level neuronal activity and behavior of C. elegans"}],"uid":"27707","created_gmt":"2021-06-30 20:00:18","changed_gmt":"2021-06-30 20:00:18","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2021-07-13T11:00:00-04:00","event_time_end":"2021-07-13T13:00:00-04:00","event_time_end_last":"2021-07-13T13:00:00-04:00","gmt_time_start":"2021-07-13 15:00:00","gmt_time_end":"2021-07-13 17:00:00","gmt_time_end_last":"2021-07-13 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"102851","name":"Phd proposal"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}