{"647370":{"#nid":"647370","#data":{"type":"event","title":"Phd Proposal by Delta Ghoshal","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EDelta Ghoshal\u003Cbr \/\u003E\r\nBME PhD Proposal\u0026nbsp;Presentation\u003C\/strong\u003E\u003Cbr \/\u003E\r\n\u003Cbr \/\u003E\r\n\u003Cstrong\u003EDate:\u003C\/strong\u003E\u0026nbsp;May 24th, 2021\u003Cbr \/\u003E\r\n\u003Cstrong\u003ETime:\u003C\/strong\u003E\u0026nbsp;10:00 AM\u003Cbr \/\u003E\r\n\u003Cstrong\u003EBlueJeans:\u0026nbsp;\u003C\/strong\u003E\u003Ca href=\u0022https:\/\/bluejeans.com\/793641575\u0022\u003Ehttps:\/\/bluejeans.com\/793641575\u0026nbsp;\u003C\/a\u003E\u003Cbr \/\u003E\r\n\u003Cbr \/\u003E\r\n\u003Cstrong\u003EThesis Committee:\u003C\/strong\u003E\u003Cbr \/\u003E\r\nKrishnendu Roy (Advisor,\u0026nbsp;Georgia Institute of Technology)\u003Cbr \/\u003E\r\nAndr\u0026eacute;s Garc\u0026iacute;a (Georgia\u0026nbsp;Institute of Technology)\u003Cbr \/\u003E\r\nAhmet Coskun (Georgia\u0026nbsp;Institute of Technology)\u003Cbr \/\u003E\r\nAnkur Singh (Georgia\u0026nbsp;Institute of Technology)\u003Cbr \/\u003E\r\nSagar Lonial (Emory\u0026nbsp;University and Winship Cancer Institute)\u003Cbr \/\u003E\r\n\u003Cbr \/\u003E\r\n\u003Cstrong\u003ETitle:\u003C\/strong\u003E\u0026nbsp;Multi-niche human bone marrow on-a-chip for\u0026nbsp;studying the interactions of adoptive cell therapies with multiple myeloma\u003Cbr \/\u003E\r\n\u003Cbr \/\u003E\r\n\u003Cstrong\u003EAbstract:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EMultiple myeloma, a cancer of bone\u0026nbsp;marrow-resident plasma cells, is the 2nd-most common hematological malignancy.\u0026nbsp;However, despite the advent of immunotherapies like chimeric\u0026nbsp;antigen receptor T\u0026nbsp;(CAR-T) cells, which gained FDA approval in March 2021, relapse is nearly\u0026nbsp;universally inevitable. The bone marrow (BM) microenvironment influences how MM\u0026nbsp;cell\u0026nbsp;survive, proliferate, and interact with stromal cells and how treatment\u0026nbsp;resistance and relapses arise; yet it is unclear which BM niches (endosteal,\u0026nbsp;central marrow, and perivascular)\u0026nbsp;interact with MM and how various cells of the\u0026nbsp;BM give rise to MM phenotypes and pathophysiology. Therefore, it is important\u0026nbsp;to recapitulate each niche in any in vitro MM model. The\u0026nbsp;overall hypothesis of\u0026nbsp;the proposed work is that a 3D, multi-niche, microvascularized culture system\u0026nbsp;will accurately model primary MM behavior and allow us to study MM interactions\u0026nbsp;with\u0026nbsp;stromal cells in the BM as well as model the responses to therapeutic\u0026nbsp;cells. To that end, a microphysiologic, microvascularized model of human MM is\u0026nbsp;proposed to enable the introduction\u0026nbsp;of various agents in order to study MM\u0026rsquo;s\u0026nbsp;response to external stimuli. The overall objective is to investigate the\u0026nbsp;heterogeneity within and among MM samples and create a physiologically\u0026nbsp;relevant\u0026nbsp;model of MM that accurately models the behavior of adoptively-transferred CAR-T\u0026nbsp;cells. We shall do this in 3 specific aims: 1) Create and characterize a\u0026nbsp;microvascularized,\u0026nbsp;microphysiological human bone marrow model to recapitulate\u0026nbsp;the tumor microenvironment of multiple myeloma. 2) Study the interaction of\u0026nbsp;CAR-T cell subsets with the MM model. 3)\u0026nbsp;Compare the behavior of CAR-T cell\u0026nbsp;subsets within the MM-chip to an in vivo model of MM.\u0026nbsp;If successful, the proposed work could be used to study\u0026nbsp;the role of the BM microenvironment\u0026nbsp;in multiple myeloma survival and\u0026nbsp;therapeutic evasion and may eventually be used to better-inform the rational\u0026nbsp;design of next-generation MM therapeutics.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Multi-niche human bone marrow on-a-chip for studying the interactions of adoptive cell therapies with multiple myeloma"}],"uid":"27707","created_gmt":"2021-05-12 15:09:41","changed_gmt":"2021-05-12 15:15:12","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2021-05-24T11:00:00-04:00","event_time_end":"2021-05-24T13:00:00-04:00","event_time_end_last":"2021-05-24T13:00:00-04:00","gmt_time_start":"2021-05-24 15:00:00","gmt_time_end":"2021-05-24 17:00:00","gmt_time_end_last":"2021-05-24 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"102851","name":"Phd proposal"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}