{"647369":{"#nid":"647369","#data":{"type":"event","title":"BioE PhD Proposal Presentation- Rebecca Schneider","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor:\u003C\/strong\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EAndr\u0026eacute;s J. Garc\u0026iacute;a, Ph.D.\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorge W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee Members:\u0026nbsp;\u003C\/strong\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EJohn Blazeck, Ph.D.\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Chemical \u0026amp; Biomolecular Engineering, Georgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EAnkur Singh , Ph.D.\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorge W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EWilbur Lam, Ph.D., MD\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDivision of Hematology\/Oncology, Department of Pediatrics, Emory University\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003ERoss Marklein, Ph.D.\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Chemical, Materials, and Biomedical Engineering, University of Georgia\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EHigh-throughput microfluidic potency assay for human mesenchymal stromal cell products with clinical prediction\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EHuman mesenchymal stromal cells (MSC) are a promising source for regenerative cell therapy. However, MSC market access has been stymied by product variability across MSC donors and manufacturing practices resulting in inconsistent clinical outcomes. The inability to predict MSC \u003Cem\u003Ein vivo\u003C\/em\u003E performance is a major limitation of MSC market penetration. Standard metrics of MSC potency employ MSC:peripheral blood mononuclear cell (PBMC) co-cultures, however, these assays are challenging to scale due to high PBMC donor variability. To address this challenge, I present a high-throughput, scalable, low-cost microfluidic MSC potency assay with improved MSC secretory correlation to \u003Cem\u003Ein vivo\u003C\/em\u003E performance. Traditional planar potency assays have been largely unsuccessful for MSC clinical translation. I demonstrate improved predictive power of the microfluidic platform compared to traditional planar methods by comparison of MSC secretory responses to PBMC co-culture assays. Further, I show analogous MSC secretory performance achieved in the microfluidic platform compared to an \u003Cem\u003Ein vivo\u003C\/em\u003E model. Lastly, with early promising results, I am now performing microfluidic potency assay validation by testing clinical samples from the multicenter MILES osteoarthritis clinical study for further system optimization and clinical validation.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioE PhD Proposal Presentation- \u0026quot;High-throughput microfluidic potency assay for human mesenchymal stromal cell products with clinical prediction\u0026quot; - Rebecca Schneider\u003C\/p\u003E\r\n","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022High-throughput microfluidic potency assay for human mesenchymal stromal cell products with clinical prediction\u0022"}],"uid":"27917","created_gmt":"2021-05-12 14:57:04","changed_gmt":"2021-05-12 14:57:04","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2021-05-27T11:00:00-04:00","event_time_end":"2021-05-27T13:00:00-04:00","event_time_end_last":"2021-05-27T13:00:00-04:00","gmt_time_start":"2021-05-27 15:00:00","gmt_time_end":"2021-05-27 17:00:00","gmt_time_end_last":"2021-05-27 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"172056","name":"go-BioE"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"10377","name":"Career\/Professional development"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}