{"646936":{"#nid":"646936","#data":{"type":"event","title":"PhD Defense by Xin Wu","body":[{"value":"\u003Cp\u003EIn partial fulfillment of the requirements for the degree of\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDoctor of Philosophy in Bioinformatics\u003C\/p\u003E\r\n\r\n\u003Cp\u003Ein the School of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EXin Wu\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDefends his thesis:\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EFUNCTIONAL EPIGENOMICS IN INSECTS USING NEXT-GENERATION SEQUENCING METHODS\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EMonday, May 3\u003Csup\u003Erd\u003C\/sup\u003E, 2021\u003C\/p\u003E\r\n\r\n\u003Cp\u003E1:00 PM Eastern Time\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Ca href=\u0022https:\/\/bluejeans.com\/9724883950\u0022\u003Ehttps:\/\/bluejeans.com\/9724883950\u003C\/a\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EThesis Advisor:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Soojin Yi\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee Members:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Michael Goodisman\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. I. King Jordan\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Christina Grozinger\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDepartment of Entomology\u003C\/p\u003E\r\n\r\n\u003Cp\u003EPennsylvania State University\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cbr \/\u003E\r\nDr. Amelia Lindsey\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDepartment Entomology\u003C\/p\u003E\r\n\r\n\u003Cp\u003EUniversity of Minnesota\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAbstract\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDNA methylation is a widespread epigenetic modification implicated in many important processes such as development, disease, and genomic imprinting. In well-studied mammalian systems, DNA methylation at gene promoters acts as a transcriptional repressor including playing a critical role in X chromosome inactivation. Despite the importance and prevalence of DNA methylation, essential model organisms such as \u003Cem\u003ED. melanogaster \u003C\/em\u003Eand \u003Cem\u003EC. elegans\u003C\/em\u003E have experienced lineage-specific losses of genomic DNA methylation. This thesis focuses on a comprehensive epigenomics survey and investigation of the \u003Cem\u003EHymenopteran\u003C\/em\u003E insect order, a group of insects including wasps, bees and ants that have retained functional DNA methylation systems. This diverse group of insects allows us to gain new insights in to the function role of DNA methylation, especially in the context of gene expression regulation. I will first provide a general survey of the epigenetic landscape of insects, which have a completely different pattern compared to mammals, and offer a new approach to quantifying and analyzing DNA methylation in these organisms. Next, I investigate changes to DNA methylation and gene expression that accompany a bacterial infection and a drastic shift from sexual to asexual reproduction in a parasitoid wasp. I will then examine how the intricate honey bee society gives rise to allele-specific methylation and its potential relationship to allele-specific expression. Finally, I explore the importance of DNA methylation along with other promoter elements in regulating gene expression variation.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"FUNCTIONAL EPIGENOMICS IN INSECTS USING NEXT-GENERATION SEQUENCING METHODS"}],"uid":"27707","created_gmt":"2021-04-27 15:58:04","changed_gmt":"2021-04-27 15:58:04","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2021-05-03T14:00:00-04:00","event_time_end":"2021-05-03T16:00:00-04:00","event_time_end_last":"2021-05-03T16:00:00-04:00","gmt_time_start":"2021-05-03 18:00:00","gmt_time_end":"2021-05-03 20:00:00","gmt_time_end_last":"2021-05-03 20:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"100811","name":"Phd Defense"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}