{"646672":{"#nid":"646672","#data":{"type":"event","title":"MS Defense by   Utku Erg\u00fcn","body":[{"value":"\u003Cp\u003EIn partial fulfillment of the requirements for the degree of\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EMaster of Science in Biology\u003C\/p\u003E\r\n\r\n\u003Cp\u003Ein the\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EUtku Erg\u0026uuml;n\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EWill defend his thesis\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u0026ldquo;\u003C\/strong\u003E\u003Cstrong\u003EThe Role of Cu, Zn Superoxide Dismutase (SOD1) in Muscle Stem Cell Function\u0026rdquo;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EWednesday, April 21\u003Csup\u003Est\u003C\/sup\u003E, 2021\u003C\/p\u003E\r\n\r\n\u003Cp\u003E2:00 PM\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Ca href=\u0022https:\/\/bluejeans.com\/694041968\u0022 target=\u0022_blank\u0022\u003Ehttps:\/\/bluejeans.com\/694041968\u003C\/a\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EMeeting ID: 694 041 968\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EThesis Advisor:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Young C. Jang\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee Members:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Shuyi Nie\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;Dr. Amit Reddi\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Chemistry and Biochemistry\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAbstract: \u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Age-related loss of muscle mass and function often referred to as sarcopenia, dramatically affects the quality of life in the elderly population and predisposes them to an increased risk of morbidity, disability, and mortality. The etiology of sarcopenia is a multi-factorial process that involves both intrinsic and extrinsic factors. However, mounting evidence from both animal and human studies suggests that uncontrolled production of reactive oxygen species (ROS) and subsequent oxidative stress and oxidative modifications to key macromolecules such as DNA, RNA, proteins, and lipids are key underlying mechanisms that exacerbate sarcopenia. Cu, Zn superoxide dismutase (SOD1) is one of the essential antioxidant enzymes that are indispensable for redox homeostasis and prevention of oxidative damage.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; To maintain skeletal muscle homeostasis and repair damaged muscle, a population of dedicated muscle stem cells (MuSC), called satellite cells, activate, express myogenic transcription factors, migrate, proliferate, and fuse with existing myofibers or form \u003Cem\u003Ede novo\u003C\/em\u003E myofibers to complete regeneration. However, increased oxidative stress in muscle stem cells may harm the muscle regeneration process by impairing the interactions between existing myofibers with newly regenerated myoblasts and muscle stem cells. Previous studies showed that the whole body-deletion of \u003Cem\u003ESod1\u003C\/em\u003E increases the age\u2010associated sarcopenia in mice; however, effects of deletion of \u003Cem\u003ESod1 \u003C\/em\u003Especifically in muscle stem cells and how it affects the muscle regeneration processes are still not known. We aimed to fill this gap by investigating the change in myogenesis and muscle regeneration of muscle stem cell-specific \u003Cem\u003ESod1\u003C\/em\u003E knock-out (MuSC-\u003Cem\u003ESod1\u003C\/em\u003EKO) mice.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Our \u003Cem\u003Ein-vivo \u003C\/em\u003Eresults revealed that the muscle regeneration and MuSC function are severely compromised in the MuSC-\u003Cem\u003ESod1\u003C\/em\u003EKO mice. Furthermore, our \u003Cem\u003Ein-vitro\u003C\/em\u003E studies show that the proliferation, differentiation, and fusion were impaired in the \u003Cem\u003ESod1\u003C\/em\u003EKO due to the increased number of apoptotic death in the myogenic progenies.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;In summary, we provide direct evidence that oxidative stress in muscle stem cells deteriorates and impairs muscle stem cell function by increasing the apoptotic response in muscle stem cells. We hope our study will open the path for better understanding the redox regulation in stem cells and aid in developing strategies to enhance stem cell-based therapies against muscle-wasting conditions, such as sarcopenia.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"The Role of Cu, Zn Superoxide Dismutase (SOD1) in Muscle Stem Cell Function"}],"uid":"27707","created_gmt":"2021-04-20 18:26:25","changed_gmt":"2021-04-20 18:26:25","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2021-04-21T15:00:00-04:00","event_time_end":"2021-04-21T17:00:00-04:00","event_time_end_last":"2021-04-21T17:00:00-04:00","gmt_time_start":"2021-04-21 19:00:00","gmt_time_end":"2021-04-21 21:00:00","gmt_time_end_last":"2021-04-21 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"111531","name":"ms defense"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}