{"646417":{"#nid":"646417","#data":{"type":"event","title":"PhD Defense by Fabrice Bernard","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EFabrice Bernard\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EPhD Defense Presentation\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EDate:\u003C\/strong\u003E Monday, April 26th 2021\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ETime:\u003C\/strong\u003E 10:00 AM\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ELocation:\u003C\/strong\u003E \u003Ca href=\u0022https:\/\/bluejeans.com\/208282976\u0022\u003Ehttps:\/\/bluejeans.com\/208282976\u003C\/a\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EThesis Advisors: \u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EJ. Brandon Dixon, PhD\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology, GW Woodruff School of Mechanical Engineering\u003C\/p\u003E\r\n\r\n\u003Cp\u003ENick Willett, PhD\u003C\/p\u003E\r\n\r\n\u003Cp\u003EEmory University School of Medicine, Department of Orthopaedics\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EThesis Committee: \u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EKyle Allen, PhD\u003C\/p\u003E\r\n\r\n\u003Cp\u003EUniversity of Florida, J. Crayton Pruitt Family Department of Biomedical Engineering\u003C\/p\u003E\r\n\r\n\u003Cp\u003EJames Dahlman, PhD\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology, WH Coulter Department of Biomedical Engineering\u003C\/p\u003E\r\n\r\n\u003Cp\u003EAndr\u0026eacute;s Garcia, PhD\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology, GW Woodruff School of Mechanical Engineering\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESusan Thomas, PhD\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology, GW Woodruff School of Mechanical Engineering\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ETitle:\u003C\/strong\u003E The Role of Microvascular Clearance in the Progression of Osteoarthritis\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAbstract:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EOsteoarthritis (OA) is the most common disease of the knee. OA is characterized by damage to the articular cartilage, underlying bone, and chronic inflammation of the joint tissues, leading to the progressive loss of joint function, increased disability, and reduced quality of life. In OA, the role of chronic low-grade inflammation has been implicated in disease progression. In wound healing, lymphangiogenesis, or the formation of new lymphatic vessels, is central to inflammation resolution. However, in the osteoarthritic synovium, lymphatic vessel density is decreased in later stages of OA, and changes in the microcirculatory environment may be responsible for joint dysfunction. Blood vessels and lymphatic vessels (the microvasculature) play a critical role in tissue maintenance and have been implicated in OA development and treatment strategies. Therefore, our objective was to understand joint clearance mechanisms under normal and diseased conditions. This thesis\u0026#39;s long-term goal was to establish biomolecular engineering strategies to assess microvascular function in normal and OA joints.\u003C\/p\u003E\r\n\r\n\u003Cp\u003EIn Aim 1, we used near-infrared (NIR) imaging techniques to non-invasively evaluate venous and lymphatic drainage in the na\u0026iuml;ve knee joint in vivo. We then perturbed joint homeostasis using exercise or endothelin-1, a cytokine elevated in human OA with strong vascular tonic activity, and investigated the effects on microvascular function and clearance mechanisms. In Aim 2, we used these techniques to determine how microvascular clearance changes during OA progression in a post-traumatic OA model in the rat. In Aim 3, we used human OA synovial fluid to study lymphatic collecting vessel contractility and lymphangiogenesis using two ex vivo platforms.\u003C\/p\u003E\r\n\r\n\u003Cp\u003ECollectively, we found that 1) joint clearance can be significantly altered by exercise or ET-1, 2) OA induction in the rat has differential effects on venous and lymphatic clearance, and 3) treatment with human OA synovial fluid reduces lymphatic collecting vessel contractility and growth ex vivo. These studies increased the fundamental knowledge about the role of the microvasculature, and specifically lymphatics, in normal joint function and during OA progression.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"The Role of Microvascular Clearance in the Progression of Osteoarthritis"}],"uid":"27707","created_gmt":"2021-04-13 15:26:31","changed_gmt":"2021-04-13 15:26:31","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2021-04-26T11:00:00-04:00","event_time_end":"2021-04-26T13:00:00-04:00","event_time_end_last":"2021-04-26T13:00:00-04:00","gmt_time_start":"2021-04-26 15:00:00","gmt_time_end":"2021-04-26 17:00:00","gmt_time_end_last":"2021-04-26 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"100811","name":"Phd Defense"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}