{"645893":{"#nid":"645893","#data":{"type":"event","title":"PhD Defense by Zahra Nassiri Toosi","body":[{"value":"\u003Cp\u003EIn partial fulfillment of the requirements for the degree of\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDoctor of Philosophy in Biology\u003C\/p\u003E\r\n\r\n\u003Cp\u003EIn the\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EZahra Nassiri Toosi\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EWill defend her dissertation\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EFunctional roles and underlying mechanism of site-specific N-terminal phosphorylation in a heterotrimeric G protein gamma subunit\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003ETuesday, April 13\u003Csup\u003Eth\u003C\/sup\u003E, 2021\u003C\/p\u003E\r\n\r\n\u003Cp\u003E1:00 PM\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Ca href=\u0022https:\/\/nam12.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fbluejeans.com%2F4537128340\u0026amp;data=04%7C01%7Ctatianna.richardson%40grad.gatech.edu%7Cc440543d85114ff973f908d8f390f03d%7C482198bbae7b4b258b7a6d7f32faa083%7C0%7C0%7C637527151136344093%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000\u0026amp;sdata=di4pf9qvXCTSRBx6aN9TxxHqKApyy%2BKVMuqLyyjsNlk%3D\u0026amp;reserved=0\u0022 target=\u0022_blank\u0022\u003Ehttps:\/\/bluejeans.com\/4537128340\u003C\/a\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u0026nbsp;\u003Cstrong\u003EThesis Advisor:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Matthew Torres, Ph.D.\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee Members:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Liang Han, Ph.D.\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Brian Hammer, Ph.D.\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Amit Reddi, Ph.D.\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Chemistry and Biochemistry\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Randy Hall, Ph.D.\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDepartment of Pharmacology and Chemical Biology\u003C\/p\u003E\r\n\r\n\u003Cp\u003EEmory University School of Medicine\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EABSTRACT: Heterotrimeric G-proteins (consisting of Ga, Gb, and Gg subunits) transduce extracellular signals such as hormones and neurotransmitters into intracellular responses that enable cells to communicate with their environment. Dysregulation of G-protein signaling pathways have significant implications in cardiovascular disease, diabetes, and cancer. Therefore, understanding the underlying signaling and regulatory mechanisms of the G-protein signaling systems is of prime importance. While several regulatory roles have been associated with Ga and Gb subunits, Gg subunits, the smallest components of the heterotrimeric G-protein complex, have been long recognized solely as membrane anchors for Gb subunits. Here, I will demonstrate a novel regulatory role for Gg subunits that is mediated through combinatorial phosphorylation of their intrinsically disordered N-terminal (Nt) tails. Using the yeast model system, I show that the Gg subunit (Ste18) undergoes multi-site phosphorylation within its disordered Nt tail in response to a range of different stimuli, such as G-protein activation and cellular stress. Phosphorylation exhibits inter-site interactivity that is controlled by multiple kinases that produce differential effects on the structure and function of Ste18-Nt subunits and output from the G protein signaling pathway. Taken together, my work sheds light on a new multi-site phosphorylation code in Gg subunits that facilitates their function as governors of G-protein signaling. Similar such codes have been described for other important proteins including histones, RNA polymerases, and G protein coupled receptors, thus placing Gg subunits among the list of intrinsically disordered proteins that exploit combinatorial post-translational modification to govern signaling pathway outputs.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Functional roles and underlying mechanism of site-specific N-terminal phosphorylation in a heterotrimeric G protein gamma subunit"}],"uid":"27707","created_gmt":"2021-03-30 16:50:42","changed_gmt":"2021-03-30 16:50:42","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2021-04-13T14:00:00-04:00","event_time_end":"2021-04-13T16:00:00-04:00","event_time_end_last":"2021-04-13T16:00:00-04:00","gmt_time_start":"2021-04-13 18:00:00","gmt_time_end":"2021-04-13 20:00:00","gmt_time_end_last":"2021-04-13 20:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"100811","name":"Phd Defense"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}