Enabling Wearable Hemodynamic Monitoring using Multimodal Cardiomechanical Sensing Systems

Biomarkers such as blood pressure and cardiac output are instrumental to understanding the pathogenesis of cardiovascular disease. Unfortunately, the monitoring of these hemodynamic parameters is still tethered to in-clinic measurements or is too unaccommodating and inconvenient for ubiquitous use. This focus of this proposed work is to explore seismocardiogram-based wearable multimodal sensing techniques to enable the use of digital biomarkers—in particular, blood pressure and cardiac output. First, the performance of a multimodal, wrist-worn device capable of obtaining noninvasive pulse transit time measurements is used to estimate blood pressure in an unsupervised, at-home setting. Second, the feasibility of this wrist-worn device is comprehensively evaluated in a diverse and medically underserved population over the course of several perturbations used to modulate blood pressure through different pathways. Finally, as part of the proposed work, the ability of wearable signals acquired from a patch to noninvasively quantify cardiac output in pediatric congenital heart disease patients is examined in a hospital setting. Successful completion of the proposed work will demonstrate that these advancements represent a step towards enabling frequent, reliable, and accurate measurements in ambulatory settings and offer an opportunity to advance health equity.