{"643891":{"#nid":"643891","#data":{"type":"event","title":"PhD Proposal by Sruti Bheri","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003ESruti Bheri\u003C\/strong\u003E\u003Cbr \/\u003E\r\n\u003Cstrong\u003EBME PhD Thesis Proposal Presentation\u003C\/strong\u003E\u003Cbr \/\u003E\r\n\u003Cbr \/\u003E\r\n\u003Cstrong\u003EDate:\u003C\/strong\u003E\u0026nbsp;February 18th\u003Cbr \/\u003E\r\n\u003Cstrong\u003ETime:\u003C\/strong\u003E\u0026nbsp;2:00 - 3:00 pm (EST)\u003Cbr \/\u003E\r\n\u003Cstrong\u003ELink:\u0026nbsp;\u003C\/strong\u003EZoom\u0026nbsp;(\u0026nbsp;\u003Ca href=\u0022https:\/\/nam12.safelinks.protection.outlook.com\/?url=https%3A%2F%2Femory.zoom.us%2Fj%2F96715712854%3Fpwd%3DaXNDdzJrSTAvUlRxSHRTNlpDcENLZz09\u0026amp;data=04%7C01%7Ctatianna.richardson%40grad.gatech.edu%7C04f8ae76792742df738b08d8c923ab90%7C482198bbae7b4b258b7a6d7f32faa083%7C0%7C0%7C637480502328183841%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000\u0026amp;sdata=M%2FZXdiVDL1iUzRmjulwvzo120mYrWZ7rtjHnMYjLKcA%3D\u0026amp;reserved=0\u0022 target=\u0022_blank\u0022 title=\u0022Original URL: https:\/\/emory.zoom.us\/j\/96715712854?pwd=aXNDdzJrSTAvUlRxSHRTNlpDcENLZz09. Click or tap if you trust this link.\u0022\u003Ehttps:\/\/emory.zoom.us\/j\/96715712854?pwd=aXNDdzJrSTAvUlRxSHRTNlpDcENLZz09\u003C\/a\u003E)\u003Cbr \/\u003E\r\n\u003Cstrong\u003EMeeting ID:\u0026nbsp;\u003C\/strong\u003E967 1571 2854\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EPasscode:\u0026nbsp;\u003C\/strong\u003E123456\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EFaculty Advisor:\u003C\/strong\u003E\u003Cbr \/\u003E\r\nMichael E. Davis, PhD\u003Cbr \/\u003E\r\n\u003Cbr \/\u003E\r\n\u003Cstrong\u003ECommittee Members:\u003C\/strong\u003E\u003Cbr \/\u003E\r\nManu Platt, PhD\u003Cbr \/\u003E\r\nVahid Serpooshan, PhD\u003Cbr \/\u003E\r\nHee Cheol Cho, PhD \u0026nbsp;\u0026nbsp;\u0026nbsp;\u003Cbr \/\u003E\r\nJulie Champion, PhD\u003Cbr \/\u003E\r\n\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ETitle:\u003C\/strong\u003E\u0026nbsp;Engineering small\u0026nbsp;extracellular vesicle-derived vehicles carrying optimized microRNA for cardiac repair after myocardial infarction\u0026nbsp;\u003Cbr \/\u003E\r\n\u003Cbr \/\u003E\r\n\u003Cstrong\u003EAbstract:\u003C\/strong\u003E\u0026nbsp;Myocardial infarction (MI) is one of the leading causes of morbidity and mortality worldwide. One promising therapy involves delivering small extracellular vesicles (sEVs), released from cardiac relevant cell types, to the infarct. These sEVs are 30-150nm vesicles containing protein and\/or nuclear cargo. Despite their reparative potential, sEV therapies have several issues due to their cellular origin, including variable sEV yield and uncontrolled and low-density cargo encapsulation.\u0026nbsp;Synthetic mimics (SUVs) have been developed which allow optimized cargo loading but these have high toxicity, compromised membranes and poor uptake. Therefore, there is a need for cell-free vehicles with sEV-like membrane and uptake, which allow delivery of higher concentrations of custom cargo. Our goal is to engineer such a vesicle to deliver tailored microRNA cargo, and induce cardiac repair post-MI. We\u0026nbsp;hypothesize\u0026nbsp;that sEV-like vesicles (ELVs) engineered using a natural membrane and loaded with customized cargo will improve cardiac tissue repair after MI compared to that of unmodified sEVs or SUVs. Aim 1 will focus on ELV synthesis and\u0026nbsp;\u003Cem\u003Ein vitro\u0026nbsp;\u003C\/em\u003Efunctional responses. Aim 2 will assess ELV potency in a rat MI model. Finally, Aim 3 will determine parent cell effects on ELV membrane composition and, in turn, ELV uptake and functionality.\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Engineering small extracellular vesicle-derived vehicles carrying optimized microRNA for cardiac repair after myocardial infarction "}],"uid":"27707","created_gmt":"2021-02-04 16:29:17","changed_gmt":"2021-02-04 16:29:17","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2021-02-18T14:00:00-05:00","event_time_end":"2021-02-18T15:00:00-05:00","event_time_end_last":"2021-02-18T15:00:00-05:00","gmt_time_start":"2021-02-18 19:00:00","gmt_time_end":"2021-02-18 20:00:00","gmt_time_end_last":"2021-02-18 20:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"102851","name":"Phd proposal"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}