{"643890":{"#nid":"643890","#data":{"type":"event","title":"PhD Proposal by Jared Beyersdorf","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EJared Beyersdorf\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EBME PhD Thesis Proposal Presentation\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDate: February 16\u003Csup\u003Eth\u003C\/sup\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003ETime: 4:00 \u0026ndash; 5:30 pm (EST)\u003C\/p\u003E\r\n\r\n\u003Cp\u003ELink:\u0026nbsp;\u003Ca href=\u0022https:\/\/nam12.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fbluejeans.com%2F4450273439\u0026amp;data=04%7C01%7Ctatianna.richardson%40grad.gatech.edu%7C3319b2f72b8240b70eaa08d8c7e149eb%7C482198bbae7b4b258b7a6d7f32faa083%7C0%7C0%7C637479117709399061%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000\u0026amp;sdata=3lOzWMB1MOHmcFGsiN7XqRHH4meQgJ%2BYqwZny%2FXP73g%3D\u0026amp;reserved=0\u0022 target=\u0022_blank\u0022 title=\u0022Original URL: https:\/\/bluejeans.com\/4450273439. Click or tap if you trust this link.\u0022\u003Ehttps:\/\/bluejeans.com\/4450273439\u003C\/a\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EAdvisor:\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EPhilip Santangelo, PhD\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EBME, Georgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003ECommittee Members:\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EKrishnendu Roy, PhD\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EBME, Georgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EWilbur Lam, MD\/PhD\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EBME, Georgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDepartment of Pediatrics, Emory University\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EJames Dahlman, PhD\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EBME, Georgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EJoseph Schoeniger, MD\/PhD\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDepartment of Systems Biology, Sandia National Laboratories\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ETitle:\u0026nbsp;\u003C\/strong\u003EDevelopment of an mRNA-based Prophylactic for Protection Against Nerve Agent Toxicity\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAbstract:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003ENerve agents are toxic compounds that rapidly lead to cholinergic crisis in humans, leaving little time for medical intervention to prevent death. To overcome limitations with current medical interventions, protein bioscavengers of nerve agents, such as butyrylcholinesterase (BChE), have been developed. BChE circulates naturally in human plasma and binds to nerve agents before they can reach nerve synapses and induce toxicity. However, natural levels are too low to provide protection. Recombinant BChE has been shown to be effective in animals and safe in Phase I clinical trials, but exceedingly high doses must be administered, which are expensive and difficult to manufacture. As an alternative, we will develop mRNA-based strategies to prophylactically overexpress BChE for nerve agent protection. This proposal aims to 1) develop direct mRNA and gene activation approaches to maximize the secretion of functional BCHE protein in human\u0026nbsp;\u003Cem\u003Ein vitro\u003C\/em\u003E\u0026nbsp;systems and mouse models, 2) characterize LNP formulations for RNA loading and patterns of transfection in vivo, and 3) utilize an RNA-based prophylactic to protect mice from lethal nerve agent intoxication. By completing these aims, we will provide the first mRNA-based demonstration of nerve agent protection and improve current understanding of mRNA-based protein therapies.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Development of an mRNA-based Prophylactic for Protection Against Nerve Agent Toxicity"}],"uid":"27707","created_gmt":"2021-02-04 16:25:11","changed_gmt":"2021-02-04 16:25:11","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2021-02-16T16:00:00-05:00","event_time_end":"2021-02-16T17:00:00-05:00","event_time_end_last":"2021-02-16T17:00:00-05:00","gmt_time_start":"2021-02-16 21:00:00","gmt_time_end":"2021-02-16 22:00:00","gmt_time_end_last":"2021-02-16 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"102851","name":"Phd proposal"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}