{"64317":{"#nid":"64317","#data":{"type":"event","title":"MSE Ph.D. Proposal - Maeling Tapp","body":[{"value":"\u003Cp\u003ETitle: In Vitro Selection of DNA Aptamers for Gold\nNanoparticles\u003C\/p\u003E\n\n\n\n\u003Cp\u003ESummary: \u003C\/p\u003E\u003Cp\u003EAptamers are\nsingle-stranded oligonucleotide sequences that exhibit high affinity and high\nspecificity binding for nonnucleotide targets.\u003C\/p\u003E\n\n\u003Cp\u003EUsing a procedure called \u0022systematic evolution of\nligands by exponential enrichment\u0022 (SELEX), aptamers can be identified\nfrom combinatorial libraries consisting of ~ 1012-1015 random sequences. This\nin vitro selection procedure has led to the discovery of aptamers for a variety\nof targets including but not limited to ions, small macromolecules, and whole\ncells. Due to their small molecular weight, ease of processing, and long-term\nstability, aptamers are now increasingly explored as potential alternatives to\nantibodies as high affinity ligands. These characteristics highlight the\npotential impact of aptamers in areas such as biosensing, diagnostics, and\ntherapeutics.\u003C\/p\u003E\n\n\n\n\u003Cp\u003EGold\nnanoparticles have been widely studied for various diagnostic, imaging and\ntherapeutic applications due to their shape and size-dependent optical\nproperties. Tight control over the size distribution and shape of gold\nnanoparticles using conventional solution precipitation approaches, however, is\nchallenging.\u0026nbsp; In addition, subsequent\nassembly of nanoparticles into well-organized spatial patterns on substrates\ncan pose additional challenges. The overall goal of the proposed research is to\nidentify aptamer sequences from a random library that bind both to gold\nnanoparticles and to gold ions.\u0026nbsp; If\nsuccessful, this approach to aptamer screening will potentially allow for the\nsimultaneous precipitation and patterning of homogeneous, spherical gold\nnanoparticles. \u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EMSE Ph.D. Proposal - Maeling Tapp - IBB 1107 @ 10:30AM\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"MSE Ph.D. Proposal - Maeling Tapp"}],"uid":"27388","created_gmt":"2011-02-17 14:39:42","changed_gmt":"2016-10-08 01:54:09","author":"Bill Miller","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2011-02-25T09:30:00-05:00","event_time_end":"2011-02-25T12:30:00-05:00","event_time_end_last":"2011-02-25T12:30:00-05:00","gmt_time_start":"2011-02-25 14:30:00","gmt_time_end":"2011-02-25 17:30:00","gmt_time_end_last":"2011-02-25 17:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"1238","name":"School of Materials Science and Engineering"}],"categories":[],"keywords":[{"id":"10802","name":"MSE_Interal_Event"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}