{"642984":{"#nid":"642984","#data":{"type":"event","title":"BioE PhD Proposal Presentation- Alyssa Pybus","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003ELevi B. Wood, Ph.D.\u003C\/p\u003E\r\n\r\n\u003Cp\u003EME, Georgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee Members:\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EErin M. Buckley, Ph.D.\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EBME, Georgia Institute of Technology and Emory University\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EMichelle C. LaPlaca, Ph.D.\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EBME, Georgia Institute of Technology and Emory University\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EManu O. Platt, Ph.D.\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EBME, Georgia Institute of Technology and Emory University\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESrikant Rangaraju, M.D.\u0026nbsp;M.S.\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDepartment of Neurology, Emory University\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ESystems Analysis of Neuroinflammation in Repetitive Mild Traumatic Brain Injury\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003ERepetitive mild traumatic brain injury (rmTBI) has been linked to devastating long-term neurological pathologies including chronic traumatic encephalopathy, which disproportionately affects athletes, military service members, and victims of domestic abuse. Despite the grave public health concern that rmTBI presents, current therapeutic strategies are limited. It is necessary to illuminate the molecular mechanisms underlying neurodegeneration after injury to identify candidate therapies.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003ENeuroinflammation is implicated in severe traumatic brain injury and represents a likely culprit for driving pathology after rmTBI. The \u003Cstrong\u003Eobjective\u003C\/strong\u003E of this study is to understand the mechanisms driving neuroinflammation after rmTBI. My \u003Cstrong\u003Ehypothesis\u003C\/strong\u003E is that neuroinflammation after rmTBI is driven by specific intracellular signaling pathways first activated in neurons, and that these pathways can be inhibited to improve outcome after rmTBI. The proposed work will identify cell type specific acute phospho-protein signaling pathways and cytokines associated with poor cognitive outcome after rmTBI, investigate neuroinflammatory signaling and its relationship to pathological progression after rmTBI in an Alzheimer\u0026rsquo;s disease mouse model, and determine whether small molecule inhibition of inflammatory signaling pathways can improve outcome after rmTBI. Uncovering signaling mechanisms driving neuroinflammation after rmTBI will identify possible therapeutic targets for pharmaceutical intervention to improve clinical outcomes of patients recovering from brain injury.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioE PhD Proposal Presentation-\u0026nbsp; \u0026quot;Systems Analysis of Neuroinflammation in Repetitive Mild Traumatic Brain Injury\u0026quot; - Alyssa Pybus\u003C\/p\u003E\r\n","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Systems Analysis of Neuroinflammation in Repetitive Mild Traumatic Brain Injury\u0022"}],"uid":"27917","created_gmt":"2021-01-15 15:55:46","changed_gmt":"2021-01-15 15:55:46","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2021-01-22T13:00:00-05:00","event_time_end":"2021-01-22T15:00:00-05:00","event_time_end_last":"2021-01-22T15:00:00-05:00","gmt_time_start":"2021-01-22 18:00:00","gmt_time_end":"2021-01-22 20:00:00","gmt_time_end_last":"2021-01-22 20:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"172056","name":"go-BioE"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"10377","name":"Career\/Professional development"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}