{"642051":{"#nid":"642051","#data":{"type":"event","title":"Ph.D. Proposal Oral Exam - Norh Asmare","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003ETitle:\u0026nbsp; \u003C\/strong\u003E\u003Cem\u003EHigh Throughput Electronic Cell Mechanotyping via Multiplexed Impedance Sensors\u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee:\u0026nbsp; \u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Sarioglu, Advisor\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. , Co-Advisor\u0026nbsp;\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Bhatti, Chair\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Frazier\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAbstract: \u003C\/strong\u003EThe objective of the proposed research is to develop and characterize a portable microfluidic device that uses an array of microconstrictive channels to determine the mechanical properties of a sample population. The parallelized channel design and dual electrical outputs makes this approach suitable for high-throughput sample characterization on a low-cost, disposable chip. Since physiological and pathological events change the mechanical properties of cells, tools that rapidly capture and quantify such changes at the single-cell level can provide key insights into the utility of cell mechanics as a label-free biomarker. In this thesis, we present a high-throughput cell mechanotyping assay that electrically measures cell viscoelastic properties (elastic modulus and fluidity) on a disposable microchip. Our approach combines an array of microconstrictions with a multiplexed network of barcoded electrical sensors that time cells\u0026rsquo; transit through those microconstrictions in parallel. By logging cells exclusively outside the slowing microconstrictions, our technique mitigates the reduction in measurement throughput caused by the time a cell spends within a microconstriction. By increasing access to currently underutilized mechanical biomarkers, this technique has significant potential to open new avenues of study and facilitate various applications within biomedicine.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"High Throughput Electronic Cell Mechanotyping via Multiplexed Impedance Sensors"}],"uid":"28475","created_gmt":"2020-12-10 21:10:57","changed_gmt":"2020-12-10 21:10:57","author":"Daniela Staiculescu","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2020-12-18T14:00:00-05:00","event_time_end":"2020-12-18T16:00:00-05:00","event_time_end_last":"2020-12-18T16:00:00-05:00","gmt_time_start":"2020-12-18 19:00:00","gmt_time_end":"2020-12-18 21:00:00","gmt_time_end_last":"2020-12-18 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"434371","name":"ECE Ph.D. Proposal Oral Exams"}],"categories":[],"keywords":[{"id":"102851","name":"Phd proposal"},{"id":"1808","name":"graduate students"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78771","name":"Public"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}