{"640827":{"#nid":"640827","#data":{"type":"event","title":"PhD Defense by Josh Palacios","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EJosh Palacios\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EBME PhD Thesis Defense\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EDate:\u0026nbsp;\u003C\/strong\u003ENovember, 3\u003Csup\u003Erd\u003C\/sup\u003E\u0026nbsp;2020\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ETime:\u0026nbsp;\u003C\/strong\u003E1:00 PM\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EBlueJeans:\u0026nbsp;\u003Ca href=\u0022https:\/\/bluejeans.com\/336471157\u0022 target=\u0022_blank\u0022\u003Ehttps:\/\/bluejeans.com\/336471157\u003C\/a\u003E\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee Members:\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EMark Prausnitz, PhD (Georgia Institute of Technology, School of Chemical and Biomolecular Engineering) (Advisor)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EWilbur Lam, MD, PhD (Georgia Institute of Technology, School of Biomedical Engineering)\u0026nbsp;\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EJulie Champion, PhD (Georgia Institute of Technology, School of Chemical and Biomolecular Engineering)\u0026nbsp;\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003ETodd Sulchek, PhD (Georgia Institute of Technology, School of Biomedical Engineering)\u0026nbsp;\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EAndrew Neish, MD (Emory University, School of Medicine)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ETitle: High velocity delivery of biologics from oral dosage forms to the gastrointestinal tract.\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAbstract:\u0026nbsp;\u003C\/strong\u003EBiologics are a class of drugs that are critical in treating numerous chronic diseases that afflict hundreds of millions of patients globally.\u0026nbsp;Generally administered through repeated injections, sometimes throughout a patient\u0026rsquo;s lifetime, these injections can be painful, and increase patient non-compliance, cost of therapy, and risk of spreading blood borne diseases. Oral delivery is preferred, but there are physiological barriers within the gastrointestinal tract (GIT) that generally reduce bioavailability of biologics to less than 2%. The mucus barrier and the epithelial cell layer are the two main barriers that play a major role in preventing the transport of biologics into systemic delivery, resulting in negligible oral bioavailability.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EThe objective of this dissertation was to improve the oral bioavailability of biologic therapeutics by using pressure-driven flow\u0026nbsp;to facilitate rapid transport across the mucus and epithelial barriers of the GIT. To accomplish this, I\u0026nbsp;first\u0026nbsp;investigated the use of pressure-driven flow as a potential mode of drug transport across the GIT in pig small intestines\u0026nbsp;\u003Cem\u003Eex vivo\u003C\/em\u003E. Next, I designed and developed oral dosage forms that eject their contents at optimal delivery pressures while in simulated gastrointestinal environments. These delivery systems are\u0026nbsp;made from biocompatible materials and excipients, can carry a variety of biologic therapeutics, and can deliver therapeutic payloads at high velocities in a controlled manner. As a proof of concept, I used these delivery systems to deliver insulin to rat small intestines\u0026nbsp;\u003Cem\u003Ein vivo\u003C\/em\u003E.\u0026nbsp;As a result, this mode of delivery significantly increased plasma concentration of insulin and significantly reduced blood glucose levels in rats compared to conventional oral delivery. Compared to subcutaneous injections there was no significant difference. In conclusion, these oral dosage forms could serve as an alternative oral delivery platform to injections that are painless, can carry a variety of biologic therapeutics, and can transport biologics rapidly across the GIT barriers, thus increasing systemic delivery.\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"High velocity delivery of biologics from oral dosage forms to the gastrointestinal tract."}],"uid":"27707","created_gmt":"2020-10-30 16:51:28","changed_gmt":"2020-10-30 16:51:28","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2020-11-03T13:00:00-05:00","event_time_end":"2020-11-03T15:00:00-05:00","event_time_end_last":"2020-11-03T15:00:00-05:00","gmt_time_start":"2020-11-03 18:00:00","gmt_time_end":"2020-11-03 20:00:00","gmt_time_end_last":"2020-11-03 20:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"100811","name":"Phd Defense"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}